Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis

O’Connor, Thomas G.; Heron, Jon; Golding, Jean; Glover, Vivette

doi:10.1111/1469-7610.00187

Cited by 624 publications

(471 citation statements)

References 53 publications

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“…These studies controlled for a number of confounding variables including SES, maternal age, birth weight, gestational age, and biomedical risks during pregnancy. Similarly, children whose mothers experienced high levels of anxiety during pregnancy exhibited higher rates of behavioral and emotional problems at 47 and 81 months of age after controlling for obstetric risks, psychosocial disadvantage, and postnatal anxiety and depression (O'Connor et al, 2003). In the present study, the numbers of inhabitants in a household and household crowding represent crude and indirect indices of psychological stress.…”

Section: Discussionmentioning

confidence: 62%

Maternal household crowding during pregnancy and the offspring's risk of schizophrenia

Kimhy

Harlap

Fennig

et al. 2006

Schizophrenia Research

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Section: Discussionmentioning

confidence: 62%

Maternal household crowding during pregnancy and the offspring's risk of schizophrenia

Kimhy

Harlap

Fennig

et al. 2006

Schizophrenia Research

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“…Although not as mechanistically revealing, the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 14 551) initiated in the United Kingdom in 1999 has reported several sex differences with respect to maternal psychosocial distress (anxiety and perceived stress) during pregnancy effects on offspring behavior during infancy and childhood (prepubertal window), and at the age of 18 (Capron et al, 2015). Even when controlling for maternal postpartum affective state and obstetrical factors, maternal anxiety late in gestation was associated most robustly with hyperactivity/ inattentiveness in boys and total behavioral/emotional problems in boys and girls assessed at 4 years of age (O'Connor et al, 2003). Later in development, sex differences with respect to maternal antenatal anxiety and cortisol awakening response in a subgroup (n = 1000) of 15-year olds from this cohort were less prominent (O'Donnell et al, 2013).…”

Section: Knowledge Gained By Including Sabv In Studies Of Neurodevelomentioning

confidence: 99%

Sex as a Biological Variable: Who, What, When, Why, and How

Bale

Epperson

2016

Neuropsychopharmacol

119

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The inclusion of sex as a biological variable in research is absolutely essential for improving our understanding of disease mechanisms contributing to risk and resilience. Studies focusing on examining sex differences have demonstrated across many levels of analyses and stages of brain development and maturation that males and females can differ significantly. This review will discuss examples of animal models and clinical studies to provide guidance and reference for the inclusion of sex as an important biological variable relevant to a Neuropsychopharmacology audience.

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“…A wealth of studies have shown that offspring of mothers with high levels of psychosocial stress, depression or anxiety are at increased risk for adverse neurodevelopmental outcomes, showing more internalizing and externalizing behavior problems (O'Connor et al 2002;O'Connor et al 2003;O'Donnell et al 2014) higher symptoms of depression (Pawlby et al 2009;Pearson et at 2013;Plant et al 2013) and alterations in biological systems such as brain morphology (Buss et al 2010) and epigenetic profiles (Oberlander et al 2016). Higher levels of cortisol during pregnancy have also been related to offspring IQ (LeWinn et al 2009), behavior and temperament (de Weerth et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Determinants of cortisol during pregnancy – The ABCD cohort

Bleker

Roseboom

Vrijkotte

et al. 2017

Psychoneuroendocrinology

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Please cite this article as: Bleker, Laura S., Roseboom, Tessa J., Vrijkotte, Tanja G., Reynolds, Rebecca M., de Rooij, Susanne R., Determinants of Cortisol During Pregnancy − the ABCD Cohort.Psychoneuroendocrinology http://dx.doi.org/10. 1016/j.psyneuen.2017.05.026 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. later adverse health consequences. However, evidence linking maternal stress to maternal cortisol values during pregnancy is inconclusive. A possible explanation for this is that other maternal factors overshadow any potential effects of stress on cortisol levels. We studied a large cohort of pregnant women with extensive data on pregnancy characteristics to determine the respective contributions of biological, environmental and psychosocial stress factors to cortisol levels in pregnancy. Methods:We used data from 3039 women from the Amsterdam Born Children and their Development-study cohort. Serum cortisol was measured in blood, collected at the first prenatal visit, at different gestational ages (median=91 days, range=40-256 days), and at various time points during the day (median=11:45h, range=08:00 -18:30h). We assessed associations between maternal serum cortisol in pregnancy and biological factors, lifestyle factors and stress factors, including depression, anxiety, pregnancy-related anxiety, work stress, parenting stress and fatigue. Results:In multivariable analysis, variables that were associated with higher cortisol levels in pregnancy were lower maternal age [1.5 nmol/l, 95%CI (0.6 to 2. Conclusions: Our data suggest that maternal cortisol during pregnancy is mainly affected by biological and lifestyle factors, but not by psychosocial factors. We suggest that psychosocial stress in Laura S. Bleker 3 pregnancy might program the fetus through other mechanisms than through altering maternal cortisol levels.

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Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis

Abstract: There is evidence that antenatal stress/anxiety has a programming effect on the fetus which lasts at least until middle childhood.

Cited by 624 publications

References 53 publications

Maternal household crowding during pregnancy and the offspring's risk of schizophrenia

Maternal household crowding during pregnancy and the offspring's risk of schizophrenia

Sex as a Biological Variable: Who, What, When, Why, and How

Determinants of cortisol during pregnancy – The ABCD cohort

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