Maternal antenatal administration of vitamin K1 results in increasing the activities of vitamin K-dependent coagulation factors in umbilical blood and in decreasing the incidence rate of periventricular-intraventricular hemorrhage in premature infants

Liu, Jing; Wang, Qi; Gao, Feng; He, Ji-wen; Zhao, Jinhui

doi:10.1515/jpm.2006.031

Cited by 13 publications

(8 citation statements)

References 19 publications

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“…Antenatal vitamin K was associated with a nonsignificant reduction in all grades of PVH (RR 0.82, 95% confidence interval (CI) 0.67-1.00) and in severe PVH (grades 3 and 4) (RR 0.75, 95% CI 0.45-1.25) for babies receiving prenatal vitamin K compared with control babies. In a subsequent RCT by Liu et al [251], 90 pregnant women in preterm labor at less than 35 weeks of gestation received vitamin K1 10 mg per day injection intramuscularly or intravenously for 2-7 days, or no such treatment. The overall rates of PVH were 32 and 52%, respectively (p=0.036), and the frequency of severe PVH was 5 and 20%, respectively (p=0.038).…”

Section: Resultsmentioning

confidence: 99%

Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions

Barros

Bhutta

Batra

et al. 2010

BMC Pregnancy Childbirth

212

174

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IntroductionInterventions directed toward mothers before and during pregnancy and childbirth may help reduce preterm births and stillbirths. Survival of preterm newborns may also be improved with interventions given during these times or soon after birth. This comprehensive review assesses existing interventions for low- and middle-income countries (LMICs).MethodsApproximately 2,000 intervention studies were systematically evaluated through December 31, 2008. They addressed preterm birth or low birth weight; stillbirth or perinatal mortality; and management of preterm newborns. Out of 82 identified interventions, 49 were relevant to LMICs and had reasonable amounts of evidence, and therefore selected for in-depth reviews. Each was classified and assessed by the quality of available evidence and its potential to treat or prevent preterm birth and stillbirth. Impacts on other maternal, fetal, newborn or child health outcomes were also considered. Assessments were based on an adaptation of the Grades of Recommendation Assessment, Development and Evaluation criteria.ResultsMost interventions require additional research to improve the quality of evidence. Others had little evidence of benefit and should be discontinued. The following are supported by moderate- to high-quality evidence and strongly recommended for LMICs:• Two interventions prevent preterm births—smoking cessation and progesterone• Eight interventions prevent stillbirths—balanced protein energy supplementation, screening and treatment of syphilis, intermittant presumptive treatment for malaria during pregnancy, insecticide-treated mosquito nets, birth preparedness, emergency obstetric care, cesarean section for breech presentation, and elective induction for post-term delivery• Eleven interventions improve survival of preterm newborns—prophylactic steroids in preterm labor, antibiotics for PROM, vitamin K supplementation at delivery, case management of neonatal sepsis and pneumonia, delayed cord clamping, room air (vs. 100% oxygen) for resuscitation, hospital-based kangaroo mother care, early breastfeeding, thermal care, and surfactant therapy and application of continued distending pressure to the lungs for respiratory distress syndromeConclusionThe research paradigm for discovery science and intervention development must be balanced to address prevention as well as improve morbidity and mortality in all settings. This review also reveals significant gaps in current knowledge of interventions spanning the continuum of maternal and fetal outcomes, and the critical need to generate further high-quality evidence for promising interventions.

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Section: Resultsmentioning

confidence: 99%

Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions

Barros

Bhutta

Batra

et al. 2010

BMC Pregnancy Childbirth

212

174

View full text Add to dashboard Cite

show abstract

“…describing alterations in the Vitamin K dependent coagulation system and subsequent risk of IVH [1,11,15,[17][18][19][20][21]. A recent study supports the assumption that this association seems to be influenced by genetic variants in genes linked to Vitamin K dependent coagulation [22].…”

Section: Several Studies Have Looked At Coagulation Tests and Subsequmentioning

confidence: 88%

“…One such example would be foetus/neonate. Trials looking at the efficacy of such therapy were initially promising [15,31], but the Cochrane review on this topic concluded that 'Vitamin K administered to woman prior to very preterm birth has not been shown to significantly prevent peri-ventricular haemorrhage in preterm infants or to improve neurodevelopmental outcomes in childhood' [32]. 8 We observed that there was some evidence that the early administration of blood products influenced the association between increased INR and increased risk of severe IVH.…”

Section: Discussionmentioning

confidence: 99%

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Elevated International Normalized Ratio (INR) is Associated With an Increased Risk of Intraventricular Hemorrhage in Extremely Preterm Infants

Williams

Odd

Bates

et al. 2019

Journal of Pediatric Hematology/Oncology

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The International Normalised Ratio (INR), a standardised method of reporting the prothrombin time, can be a surrogate marker of the vitamin K dependent coagulation pathways. Objective: To evaluate the relationship between INR measurements in the first 48 hours of life, and subsequent development of Intra Ventricular Haemorrhage (IVH) in extremely preterm infants. Methods: Single centre retrospective, observational cohort study of infants born at less than 28 weeks gestation. Main outcome measure was defined as the degree of IVH seen on cranial ultrasound examinations at day 7 postnatal age. Results: 109/200 infants (mean gestational age 25.2 weeks (SD 1.27)) had coagulation results available. 26/109 developed IVH. Increased INR was associated with increased risk of a severe IVH OR 5.66 (1.56-20.59; p=0.008) and OR 6.50 (1.65-25.62; p=0.008) adjusted for gestation, birth weight and gender. INR was strongly associated with severe IVH in infants who did not receive blood products (OR 64.60 (1.35-3081.25)), p=0.035), but not in those who did (OR 2.93 (0.67-12.71), p=0.151)(pinteraction=0.086). Conclusion: An elevated INR in the first 48 hours of life may be useful to identify preterm infants at risk of severe IVH and may guide strategies to prevent the development, or limit the extension, of IVH.

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“…Serum osmolality, multiple births and cesarean section were not significantly correlated with the incidence of PIVH in premature infants. Maternal antenatal administration of vitamin K 1 or corticosteroids can significantly decrease the incidence of PIVH (13,14), and can be used routinely for women at risk of premature birth at <35 weeks of gestation. Antenatal supplementation with vitamin K 1 may significantly increase the plasma activities of factors II, VII and X, and consequently decrease the incidence of PIVH and lower the severity of hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

General evaluation of periventricular-intraventricular hemorrhage in premature infants in mainland China

Liu¹,

Chang²,

Wang³

et al. 2010

J Turkish German Gynecol Assoc

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Objective:To explore the incidence and analyze the high risk factors of PIVH in premature infants in mainland China. Materials and Methods:A total of 1122 premature infants at <37 weeks gestation were enrolled in this study. All the infants received intracranial ultrasound examinations within 1 week after birth,and the perinatal data were recorded to analyze the high risk factors for PIVH. Results:The results showed that the incidence rate of PIVH was 55.2% in mainland Chinese population. Among these cases, mild degrees of PIVH accounted for 82.2% and severe degrees of PIVH accounted for only 17.8%. The most important risk factors related to PIVH were low gestational age, low birth weight, low Apgar score and ventilatory treatment, etc. Conclusions:It suggested that there were many high risk factors related to PIVH in premature infants and a screening cutoff point of 2000 g appeared to be more adequate for China. (J Turkish-German Gynecol Assoc 2010; 11: 73-7) Key words: Periventricular-intraventricular Abstract ÖzetOriginal Investigation 73

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Maternal antenatal administration of vitamin K1 results in increasing the activities of vitamin K-dependent coagulation factors in umbilical blood and in decreasing the incidence rate of periventricular-intraventricular hemorrhage in premature infants

Abstract: Administration of vitamin K1 to pregnant women at less than 35 weeks' gestation age may result in improved coagulation and may reduce the incidence as well as the severity degree of PIVH.

Cited by 13 publications

References 19 publications

Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions

Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions

Elevated International Normalized Ratio (INR) is Associated With an Increased Risk of Intraventricular Hemorrhage in Extremely Preterm Infants

General evaluation of periventricular-intraventricular hemorrhage in premature infants in mainland China

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