Maternal and paternal family history of type 2 diabetes differently influence lipid parameters in young nondiabetic Japanese women

Abstract

Objectives We assessed the association of family history of type 2 diabetes (T2D) with parameters used for health checkups in young Japanese women. Methods The subjects were 497 nondiabetic women aged 19-39 years. Among them, the mothers of 34 subjects and fathers of 50 had T2D (MD group and PD group, respectively). The subjects were assessed for levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG). Results TC and LDL-C level showed a tendency to increase in the MD group compared with subjects without family history of T2D. LDL-C/HDL-C ratio C2.14 was found in 32.4 and 18.0 % of subjects in the MD and PD groups, respectively. When adjusted for differences in age, body mass index, smoking status, and drinking habits, the MD group was found to have a higher risk of abnormal TC and LDL-C levels than the PD group. LDL-C/HDL-C ratio was independently associated with maternal family history but not with paternal family history (odds ratio 3.44 [99 % confidence interval 1.11-10.6] and 1.21 [0.38-3.89], respectively). There was no association between TG/HDL-C ratio and family history type of T2D. Conclusions Maternal family history of T2D had a more pronounced effect on the lipid parameters generally evaluated during health checkups than did paternal family history of T2D. Therefore, we recommend systematic screening for early detection and appropriate healthcare guidance for Japanese women, particularly those with maternal family history of T2D.

Maternal history of diabetes is associated with increased cardiometabolic risk in Chinese

“… 5 , 7 , 28 , 42 , 43 We noted in our study that when compared with either the group without parental diabetes or the group with paternal diabetes, offspring with maternal diabetes were more obese, more centrally obese and insulin resistant, had higher glucose levels and BP, and worse lipid profiles in the present study. Recently, similar findings have been also reported by Tan et al , 8 Groop et al , 18 Ekoe et al , 44 Kasperska-Czyzyk et al , 45 Bjornholt et al 16 and Sasaki et al 46 In addition, we found that positive maternal history of diabetes was associated with impaired first-phase insulin secretion (at 0–30 min during OGTT). Interestingly, our finding is in agreement with the observation reported by Praveen et al , 47 Otabe et al 48 and Kasperska-Czyzyk et al 45 that maternal diabetes was associated with a trend towards lower DI (0–120 min) and β-cell dysfunction.…”

Effects of Obesity and Family History of Diabetes on the Association ofCETPrs6499861 with HDL-C Level in Korean Populations

“… 16 In a Japanese study, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio was independently associated with maternal family history of type 2 diabetes. 15 A study found that a high polyunsaturated fatty acid/saturated fatty acid ratio was related to lower insulin sensitivity and the protective effect of PPARG2 Pro12Ala allele was obvious in subjects with family history of type 2 diabetes. 20…”

“… 13 14 Family history of diabetes (FHD) is also related to lipid levels. 15 16 In this study, we hypothesized that CETP variants would be linked to HDL-C level in Korean populations. To test this hypothesis, we evaluated the association between HDL-C level and the rs6499861 and rs12708980 CETP gene SNPs in Korean men and women.…”

Peran Riwayat Ayah Diabetes Melitus Tipe 2 pada Status Prediabetes Anak Kandung Penderita Diabetes Melitus Tipe 2

“…Namun, studi pada perempuan Jepang oleh Sasaki, dkk. 12 melaporkan bahwa riwayat DM pada ibu mempunyai efek yang lebih besar pada parameter lipid dibandingkan dengan riwayat DM pada ayah. Grasemann, dkk.…”