Maternal and neonatal complications in women with medical comorbidities and preeclampsia

Tanner, Michael S.; Malhotra, Atul; Davey, Mary‐Ann; Wallace, Euan; Mol, Ben Willem J.; Palmer, Kirsten

doi:10.1016/j.preghy.2021.12.006

Cited by 10 publications

(9 citation statements)

References 25 publications

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“…In addition, these results supported the clinical burden of obesity and obesity-related morbidities, which focused in this study on the clinical care of the mothers and their babies. During antenatal care, medical comorbidities including obesity, DM, and hypertension are increasingly prevalent [28], and as supported by the findings of this study, such as increased birthweight and cesarean rate, and NICU admission despite an effort to reduce the effects of obesity, the results of the current study highlight the importance of improved follow-up of these pregnant women as a requirement to reduce maternal and fetal/neonatal morbidities.…”

Section: Discussionsupporting

confidence: 72%

Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and Gestational Hypertension

Güleroğlu¹,

Selvi

Bakirci

et al. 2022

Z Geburtshilfe Neonatol

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Aims We evaluated the clinical value of selected serum biomarkers BMP-4, BMP-2, GDF-15, MMP-9, and GP39 in pregnant women with obesity and the comorbidities diabetes mellitus (DM) and gestational hypertension (GHT). Methods This observational study had groups of controls, including healthy pregnant women; women with only obesity, including pregnant women with BMI≥30 kg/m2; women with gestational DM (GDM) with obesity, including pregnant women with GDM and obesity; women with pregestational DM (PGDM) with obesity, including pregnant women with PGDM and obesity; and women with GHT with obesity, including pregnant women with GHT and obesity. We measured serum levels of selected biomarkers by ELISA. ResultsObesity increased serum levels of all the biomarkers; GDM developed in obese women caused a more pronounced increase in the serum levels of BMP-4 and BMP-2, and GHT developed in obese women caused a more pronounced increase in the serum levels of GDF-15. In the women with GDM-, PGDM-, and GHT-complicated obesity, serum levels of MMP-9 and GP39 did not change meaningfully. Conclusions Obesity and its comorbidities DM and GHT lead to meaningful changes in the studied serum biomarkers. Since obesity has a causal effect on developing numerous conditions, reliable clinical biomarkers are needed to improve the early prediction and diagnosis of high-risk conditions during pregnancy.

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Section: Discussionsupporting

confidence: 72%

Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and Gestational Hypertension

Güleroğlu¹,

Selvi

Bakirci

et al. 2022

Z Geburtshilfe Neonatol

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“…An age of 40 years or more was observed in five (16.1%) patients with PE. Approximately 61.2-76.1% of preeclampsia cases, especially severe, may be attributed to an underlying extragenital pathology [14]. In this regard, extragenital pathology (such as arterial hypertension, chronic kidney disease, autoimmune diseases, diabetes mellitus, body mass index (BMI) of 35 kg/m 2 , age 40 years or older) is a risk factor for the development of the disease according to the National Institute for Health and Care Excellence, American College of Obstetricians and Gynecologists [15,16].…”

Section: Population Characteristics Of the Study Participantsmentioning

confidence: 99%

Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study

et al. 2022

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We sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolite profiles and found that they differed between pregnant women with and without preeclampsia. Lipids and sugars were identified as components of the metabolite profile that are likely to be associated with the development of preeclampsia. While PE was established only in the third trimester, a set of metabolites specific for the third trimester, including 2-(acetylamino)-1,5-anhydro-2-deoxy-4-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol, N-Acetyl-D-glucosaminyldiphosphodolichol, Cer(d18:0/20:0), and allolithocholic acid, was already traced in the first trimester. These components are also likely involved in lipid metabolism disorders and the development of oxidative stress.

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“…HDP is a significant risk factor for preterm births. It is accepted that neonatal morbidity and mortality rates in pregnancies complicated with preeclampsia or HELLP syndrome increase due to preterm births 20 . Our study revealed significant differences between the groups regarding the week of birth and birth weight.…”

Section: Discussionmentioning

confidence: 47%

“…It is accepted that neonatal morbidity and mortality rates in pregnancies complicated with preeclampsia or HELLP syndrome increase due to preterm births. 20 Our study revealed significant differences between the groups regarding the week of birth and birth weight. We determined that the gestational age and weight were less in pregnancies complicated with HELLP syndrome.…”

Section: Discussionmentioning

confidence: 57%

The role of haptoglobin in the diagnosis of preeclampsia and HELLP syndrome and in predicting neonatal outcomes

Ünal

Dal

Karagün

et al. 2023

J of Obstet and Gynaecol

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ObjectiveThe study aimed to determine whether maternal serum haptoglobin values could have an effect on predicting diagnosis and neonatal outcomes in preeclampsia and HELLP syndrome.Materials and MethodsHundred sixteen pregnant women who met the inclusion criteria were included in the study. To evaluate whether serum haptoglobin level in maternal blood could be used in early diagnosis of preeclampsia and HELLP syndrome, 49 pregnant women diagnosed with preeclampsia and 13 pregnant women diagnosed with HELLP syndrome were included in the study group, and 54 healthy pregnant women in the control group. The groups were compared regarding maternal serum haptoglobin level, platelet count, ALT, AST, LDH, and uric acid levels. Moreover, the age, obstetric histories, and newborn outcomes of all pregnant women were recorded and compared between groups.ResultsThe mean haptoglobin values were 0.29 ± 0.23 g/L in the HELLP syndrome group, 1.01 ± 0.52 g/L in the preeclampsia group, and 1.16 ± 0.37 g/L in the control group. The mean haptoglobin result was lower in the HELLP syndrome group compared to the preeclampsia and control groups (p < 0.001). While the differences between HELLP syndrome and the control and preeclampsia groups were statistically significant, no significant difference was determined between the preeclampsia and control groups. There was a significant positive correlation between haptoglobin value with the week of delivery, umbilical cord pH value, and the first and fifth‐minute Apgar scores (p < 0.05).ConclusionIt was concluded that haptoglobin values could be used together with other biochemical parameters to diagnose HELLP syndrome and predict newborn outcomes.

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Maternal and neonatal complications in women with medical comorbidities and preeclampsia

Cited by 10 publications

References 25 publications

Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and Gestational Hypertension

Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and Gestational Hypertension

Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study

The role of haptoglobin in the diagnosis of preeclampsia and HELLP syndrome and in predicting neonatal outcomes

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