Maternal and infant death after probable vertical transmission of chikungunya virus in Brazil – case report

Oliveira, Rhaquel de Morais Alves Barbosa; Barreto, Francisca Kalline de Almeida; Maia, Ana Maria Peixoto Cabral; Gomes, Ileana Pitombeira; Simião, Adriana Rocha; Barbosa, Rebeca Bandeira; Rodrigues, Adilina Soares Romeiro; Lopes, Kilma Wanderley; Araújo, Fernanda Montenegro de Carvalho; Vale, Regina Lúcia Sousa do; Cavalcante, John Washington; Cavalcanti, Luciano Pamplona de Góes

doi:10.1186/s12879-018-3243-1

Cited by 15 publications

(19 citation statements)

References 21 publications

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“…Most studies (n = 35; 83,3%) were case reports and case series [ 9 , 16 – 21 , 23 – 42 , 45 – 49 , 51 – 53 ]. The clinical and perinatal manifestations of pregnancy and the outcome of gestation were described in ten studies [ 9 , 10 , 16 – 21 , 23 , 25 , 27 , 49 – 51 ]. Stillbirths and miscarriage associated with CHIKV vertical transmission with laboratory evidence were reported in three studies [ 9 , 50 , 54 ].…”

Section: - Resultsmentioning

confidence: 99%

“…In the other one, a 28-year-old pregnant woman with hypertension presented with symptoms compatible with an arboviral disease at 34 weeks’ gestation. She developed preeclampsia with severe respiratory failure which resulted in the emergency cesarean section, and the patient died 12 days after the onset of symptoms [ 25 ].…”

Section: - Resultsmentioning

confidence: 99%

“…Most studies (n = 35; 83,3%) were case reports and case series [9,[16][17][18][19][20][21][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][45][46][47][48][49][51][52][53]. The clinical and perinatal manifestations of pregnancy and the outcome of gestation were described in ten studies [9,10,[16][17][18][19][20][21]23,25,27,[49][50][51]. Stillbirths and miscarriage associated with CHIKV vertical transmission with laboratory evidence were reported in three studies …”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

“…All included studies (n = 42) reported CHIKV vertical transmission confirmed by laboratory and clinical-epidemiological evidence in pregnant women (Table 1). The maternal infection diagnosis was confirmed by molecular and serological tests in 31 (73.8%) studies [6,9,10,[16][17][18][19][20][21][22][23][24][25][26][27][28]30,31,[33][34][35]39,41,[43][44][45][47][48][49][50][51]53,54] and in 243 (96.8%) women.…”

Section: Pregnancy Outcome Clinical and Perinatal Characteristics Of The Pregnant Women (Table 2)mentioning

confidence: 99%

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Vertical transmission of chikungunya virus: A systematic review

et al. 2021

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Objectives To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate. Study design We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded. Results From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life. Conclusions We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. A limitation of our review was that it was not possible to carry out meta-analysis due to differences in study design and the small number of participants.

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Section: - Resultsmentioning

confidence: 99%

Section: - Resultsmentioning

confidence: 99%

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

Section: Pregnancy Outcome Clinical and Perinatal Characteristics Of The Pregnant Women (Table 2)mentioning

confidence: 99%

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Vertical transmission of chikungunya virus: A systematic review

et al. 2021

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“…Other manifestations include arthralgias and myalgias, and neurological complications in severe cases. Seizures are a common neurological manifestation in CHIKVinfected children [55][56][57][58].…”

Section: Clinical Characteristicsmentioning

confidence: 99%

Arbovirus and seizures

Zheng

Hogan

et al. 2020

Acta Epileptologica

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The high prevalence and spread of arthropod-borne viruses (arboviruses) make them an important cause of viral encephalitis in humans. Most epidemic viral encephalitides have an etiology associated with arboviruses. Among various arboviruses, the Japanese encephalitis virus, West Nile virus, Zika virus, Dengue virus and Chikungunya virus can induce seizures. Arboviruses of the genus Flavivirus are usually transmitted by mosquitoes and other host animals. These vector-borne pathogens can cause epidemic viral encephalitis. Seizures may not be the major manifestation in these viral encephalitides, but may predict a poor prognosis. In this article, we discuss the relationships between these viruses and seizures from perspectives of clinical characteristics, pathogenesis, prognosis and treatments of each.

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Neonatal infection and leucocyte disorders

2022

Neonatal Haematology

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Maternal and infant death after probable vertical transmission of chikungunya virus in Brazil – case report

Cited by 15 publications

References 21 publications

Vertical transmission of chikungunya virus: A systematic review

Vertical transmission of chikungunya virus: A systematic review

Arbovirus and seizures

Neonatal infection and leucocyte disorders

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