Maternal and Fetal Toxicity of Carisoprodol Drug (Somadril Compound) on Pulmonary Tissues of Albino Rats

Abstract

Carisoprodol is a common muscle relaxant indicated as adjunctive therapy in acute, painful musculoskeletal cases. This current study aimed to investigate the histopathological, histochemical and immunohistochemical effects in the lung tissue of the pregnant rats and their fetuses after carisoprodol treatment. The present study was applied on twenty seven pregnant female rats and they were randomly divided into three groups (nine pregnant female rats in each group). Rats of the first (control) group were administered oral doses of distilled water. Rats of the second (S1) and third groups (S2) were administered oral doses of carisoprodol in the distilled water equivalent to 10.8 mg and 21.6 mg/100g body weight/day respectively for fifteen days from the six to the twenty day of gestation. Several histopathological, histochemical and some immunohistochemical changes were studied to detect the pathological changes. Maternal and fetal pulmonary tissues of both treated groups showed numerous degenerative changes post-treatment with carisoprodol, the severity of these changes was more obvious in the fetal lung tissue of both groups. Also, carisoprodol treated rats showed a marked increase in caspase-3 content in the maternal and fetal pulmonary tissues. Treatment of pregnant rats with carisoprodol drug led to numerous dystrophic changes in both maternal and fetal lung tissues.

Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with

“…In a previous study,carisoprodol treatment of the pregnant rats caused severe variations in the esophageal tissue of fetuses such as : highly thickened mucosal layers with lots of vacuolated cells and highly distorted submucosal layer, discontinuous and ruptured muscle fibres in the muscularis after administrated of carisoprodol (7) . Also, lung of treated rats with somadril showed congested alveolar septa, highly congested blood vessels which contained haemolysed blood cells,highly thickened alveolar septa, reduced alveolar sacs with thickened and corrugated epithelial layer of the bronchioles (8) .…”

“…These investigations agree with those of Abouel-Maged (9) , Anwar et al (10) and Ali et al (28) who found that treated adult male rats with somadril at 200 mg/kg led to destruction of the histological architecture of the seminiferous tubules, testicular vacuolation and degeneration and reduced spermatozoa within the lumen of the testis. Treatment of carisoprodol at doses 10.8 and 21.6 mg/kg caused degenerative changes in the lung, esophagus and liver tissues of the pregnant rats and their fetuses (7)(8)(9) .…”

“…Results of the current study revealed an increase of polysaccharides in the fetal skeletal muscle fibres of S1 and S2 groups in a dose-dependent manner as compared to the control group. Such increasein polysaccharides may be due to the increase of red blood corpuscles after toxicity (8) .…”