Carisoprodol-Induced Histological and Immunohistochemical Changes in Spleen of Pregnant Rats

Abstract

INTRODUCTIONMuscle relaxants, also known as myorelaxants, are a class of chemical compounds that relax the skeletal muscle and are used to minimize the need for anaesthesia and make intubation easier (Vardanyan and Hruby, 2006).Skeletal muscle relaxants can work in both the central and peripheral nervous systems. Carisoprodol (Soma), chlorphenesin carbamate (Maolate), and chlorzoxazone are centrally acting skeletal muscle relaxants (Parafon Forte). Dantrolene, atracurium besylate (Tracrium), and decamethonium bromide (Syncurine, C-10) are peripheral-acting relaxants (Plumlee, 2004). Carisoprodol (Nisopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate) is a muscle-skeletal relaxant that was licenced as an unregulated drug in the United States (US) in 1959 for the treatment of acute and painful musculoskeletal disorders (Patil et al., 2020).