Maternal and fetal serum leptin levels and their association with maternal and fetal variables and labor: A cross-sectional study

Obeidat, Rawan; Abdo, Nour; Sakee, Baraa; Alghazo, Shahed; Jbarah, Omar F.; Hazaimeh, Ethar; Albeitawi, Soha

doi:10.1016/j.amsu.2021.103050

Cited by 8 publications

(10 citation statements)

References 39 publications

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“…This is consistent with the results observed in clinical studies showing a link between obesity/leptin and PTB [5][6][7]19]. Maternal LEP and LEPR polymorphisms were significantly associated with increased risk for PTB [19] and additionally, in women in active labour compared to those who were not in labour or before labour induction [34,35].…”

Section: Discussionsupporting

confidence: 91%

Leptin-Induced HLA-G Inhibits Myometrial Contraction and Differentiation

Wendremaire

López

Barrichon

et al. 2022

Cells

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Maternal obesity is associated with a wide spectrum of labour disorders, including preterm birth. Leptin, a pro-inflammatory adipokine and a key factor of obesity, is suspected to play a major role in these disorders. OB-R, its receptor, is expressed on macrophages and myocytes, two cell types critical for labour onset. Macrophages secrete reactive oxygen species/pro-inflammatory cytokines, responsible for myometrial differentiation while myocytes control uterine contractions. In this study, we assessed the effect of leptin on myometrial contraction and differentiation using our validated co-culture model of human primary macrophages and myocytes. We demonstrated that leptin had a different effect on myocytes and macrophages depending on the dose. A low leptin concentration induced a tocolytic effect by preventing myocytes’ contraction, differentiation, and macrophage-induced ROS production. Additionally, leptin led to an increase in HLA-G expression, suggesting that the tocolytic effect of leptin may be driven by HLA-G, a tolerogenic molecule. Finally, we observed that recombinant HLA-G also prevented LPS-induced ROS production by macrophages. Altogether, these data provide a putative molecular mechanism by which leptin may induce immune tolerance and therefore interfere with labour-associated mechanisms. Therefore, HLA-G represents a potential innovative therapeutic target in the pharmacological management of preterm labour.

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Section: Discussionsupporting

confidence: 91%

Leptin-Induced HLA-G Inhibits Myometrial Contraction and Differentiation

Wendremaire

López

Barrichon

et al. 2022

Cells

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“…Оценка адипокинового статуса во время беременности представляет сложную задачу, так как уровень гормонов жировой ткани подвержен существенным колебаниям в зависимости от ряда факторов: особенностей течения и срока беременности, наличия гестационных осложнений (преэклампсии), особенностей внутриутробного роста плода [12]. Остается открытым вопрос о возможности использования лептина 2012) была установлена взаимосвязь материнских сывороточных адипокинов с фетальной макросомией [13], однако, по данным других исследований, внутриутробный рост плода не был связан с концентрацией лептина и адипонектина в сыворотке крови беременной в III триместре [14,15]. По нашим данным, при проведении внутригруппового корреляционного анализа между адипокинами в сыворотке крови беременной женщины перед родоразрешением и антропометрическими показателями новорожденных детей корреляционная связь отсутствовала.…”

Section: таблица 4 уровень гликированного гемоглобина до беременности...unclassified

Contribution of Biomarkers of Carbohydrate and Lipid Profile to the Formation of Fetal Macrosomia

Виктор¹,

Курлович²,

Ващилина³

et al. 2023

Репродуктивное Здоровье. Восточная Европа

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Цель исследования. Оценить взаимосвязь между показателями углеводного и липидного обмена матери и формированием фетальной макросомии. Материалы и методы. Проведен анализ показателей углеводного обмена (глюкоза плазмы венозной крови натощак, гликированный гемоглобин) и липидного обмена (общий холестерин, триглицериды, липопротеины высокой и низкой плотности (ЛПВП, ЛПНП), соотношение ЛПВП/ЛПНП, лептин, адипонектин, соотношение адипонектин/лептин) у 76 беременных женщин с сахарным диабетом и 113 беременных женщин без нарушений углеводного обмена. Пропорциональность развития макросомных новорожденных определяли с помощью масса-ростового индекса и его центильной оценки относительно срока гестации и пола новорожденного с использованием онлайн-калькулятора INTERGROWTH-21st. Результаты. Уровень гликированного гемоглобина 6,5% и более в III триместре у беременных с сахарным диабетом является высокочувствительным (85,0%) предиктором формирования непропорциональной формы фетальной макросомии. Уровень материнских сывороточных адипокинов является фактором, ассоциированным с метаболическими нарушениями беременной женщины, но не оказывает прямого влияния на формирование фетальной макросомии. Дислипидемия (повышение уровня триглицеридов и соотношения ЛПНП/ЛПВП за счет снижения ЛПВП) в III триместре беременности наряду с нарушениями углеводного обмена повышает риск формирования фетальной макросомии. Заключение. Углубленный контроль биомаркеров углеводного и липидного профиля является важной составляющей первичной профилактики фетальной макросомии. Purpose of the study. To evaluate the relationship between indicators of carbohydrate and lipid metabolism of the mother and the formation of fetal macrosomia. Materials and methods. The analysis of indicators of carbohydrate metabolism (fasting venous blood plasma glucose, glycated hemoglobin) and lipid metabolism (total cholesterol, triglycerides, high and low density lipoproteins, HDL/LDL ratio, leptin, adiponectin, adiponectin/leptin ratio) was carried out in 76 pregnant women with diabetes and 113 pregnant women without carbohydrate metabolism disorders. The proportionality of the development of macrosomal newborns was determined using the mass-height index and its centile assessment relative to the gestational age and sex of the newborn using the INTERGROWTH-21st online calculator. Results. The level of glycated hemoglobin of 6.5% or more in the III trimester in pregnant women with diabetes mellitus is a highly sensitive (85.0%) predictor of the formation of a disproportionate form of fetal macrosomia. The level of maternal serum adipokines is a factor associated with metabolic disorders of a pregnant woman, but does not directly affect the formation of fetal macrosomia. Dyslipidemia (increased triglyceride levels and LDL/HDL ratio due to a decrease in HDL) in the third trimester of pregnancy, along with carbohydrate metabolism disorders, increases the risk of fetal macrosomia. Conclusion. In-depth control of carbohydrate and lipid profile biomarkers is an important component of the primary prevention of fetal macrosomia.

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“…1,4 A high level of pregestational body fat is the main anthropometric factor associated with the abnormal elevation of maternal leptin during pregnancy. 5 It is frequently associated with increased gestational weight gain, postpartum weight retention, and obstetric complications such as recurrent miscarriage and pre-eclampsia. 1,2 Biological models indicate that excessive or imbalanced supplementation with micronutrients (folic acid, vitamin B6, vitamin B12, choline, and betaine) are associated with abnormal production of maternal leptin, either by promoting weight gain (visceral obesity) 6,7 or supporting the onset of metabolic conditions associated with leptin resistance, such as dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

“…A high level of pregestational body fat is the main anthropometric factor associated with the abnormal elevation of maternal leptin during pregnancy 5 . It is frequently associated with increased gestational weight gain, postpartum weight retention, and obstetric complications such as recurrent miscarriage and pre‐eclampsia 1,2 .…”

Section: Introductionmentioning

confidence: 99%

Gene expression of cardiovascular risk markers in mononuclear cells of pregnant woman in relation to plasma leptin and homocysteine levels: A cross sectional study

Abundis,

Hernandez‐Landero,

Escobar‐Calderon

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo investigate the relationship between anthropometric, biochemical, and hematologic parameters and serum leptin and homocysteine (Hcy) levels. Also, to determine the effect of leptin and Hcy on expression of genes associated with cardiovascular disease susceptibility (APOA1, LRP1, COX‐1, and COX‐2) in mononuclear cells of healthy pregnant women.MethodsBetween August 2018 and January 2020, a cross‐sectional study was conducted on 161 healthy pregnant women in Tabasco, southeastern Mexico. The study population was classified by trimester, according to gestational pregnancy. Anthropometric, biochemical (leptin and homocysteine), and hematologic data were obtained under fasting conditions. APOA1, LRP1, COX‐1, and COX‐2 expression in mononuclear cells was evaluated using RT‐qPCR.ResultsRed cell indices (hemoglobin, hematocrit, and erythrocytes) were negatively and positively correlated with leptin and Hcy levels, respectively, in the first‐ and second‐trimester groups. Increased leptin levels and low red cell indices were significantly associated with BMI <25.0 in the second‐trimester group; however, no significant differences were observed in Hcy levels. Increased leptin and Hcy levels were significantly associated with high lipid indicators in the first‐ and third‐trimester groups, respectively. High APOA1 and COX‐2 expression was significantly associated with reduced leptin and increased Hcy levels in the second‐ and third‐trimester groups.ConclusionIncreased leptin and Hcy levels during pregnancy, mainly associated with modifications in erythrocytes and lipid indices, may lead to early modification of genes related to lipid metabolism (APOA1) and proinflammatory response (COX‐2) and, thereby, increase cardiovascular disease risk.

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Maternal and fetal serum leptin levels and their association with maternal and fetal variables and labor: A cross-sectional study

Cited by 8 publications

References 39 publications

Leptin-Induced HLA-G Inhibits Myometrial Contraction and Differentiation

Leptin-Induced HLA-G Inhibits Myometrial Contraction and Differentiation

Contribution of Biomarkers of Carbohydrate and Lipid Profile to the Formation of Fetal Macrosomia

Gene expression of cardiovascular risk markers in mononuclear cells of pregnant woman in relation to plasma leptin and homocysteine levels: A cross sectional study

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