Maternal and Fetal Outcomes of Pregnancy-related Hypertensive Disorders in a Tertiary Care Hospital in Sukkur, Pakistan

Nisa, Shoaib Un; Shaikh, Altaf Ahmed; Kumar, Raj

doi:10.7759/cureus.5507

Cited by 20 publications

(26 citation statements)

References 14 publications

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“…Pregnancy-related hypertensive disorders are a significant cause of adverse maternal and fetal outcomes. 9 Out of the total 200 subjects, Caesarean section was done in majority of the cases (65%). 32.5% underwent vaginal delivery while 2.5% died before delivering the baby.…”

Section: Discussionmentioning

confidence: 99%

“…12 The decision to perform cesarean section should be based on fetal gestational age, fetal condition and presence of associated obstetric indications (mal presentations or the other high-risk factors), cervical bishop score and maternal condition but not merely by the presence of eclampsia. 9,15,18,19 As most of patients having caesarean section were delivered within 1 to 4 hours of admission, the feto-maternal outcome was better in them. Therefore, convulsion delivery interval has had a significant impact on maternal and perinatal mortality.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of maternal and perinatal morbidity and mortality in eclampsia by early termination of pregnancy

Mondal

Lahiri

2020

Int J Res Med Sci

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Background: Eclampsia is one of the leading causes of maternal mortality in India.Methods: A prospective observational study was done on 200 pregnant women admitted with antepartum eclampsia in Malda Medical College from 1 April 2017 to 30 October 2019. Group A included patients who delivered through vaginal route within 10 to 12 hrs of eclampsia by stabilisation of patients while Group B included subjects who underwent early caesarean section for uncontrolled convulsions or poor Bishop score. Maternal and perinatal outcomes were compared between the groups. Data was recorded in a pretested performa and was analyzed using appropriate statistical methods with SPSS.Results: Caesarean section (group B) was done in 130 cases (65%) while vaginal delivery (group A) was done in 65 cases (37.5%). Group A had higher maternal mortality (10.7%) in comparison to group B (4.6%) which was statistically not significant (p=0.1075). There were 32 neonatal deaths (24.6%) and 11 still births (8.46%) in group A while there were 12 neonatal deaths (18.46%) and 3 still births (4.61%) in group B. There was a statistically significant difference (p<0.0001) between the groups with respect to total perinatal deaths.Conclusions: Antenatal and intranatal eclampsia should be managed by early termination of pregnancy preferably with Caesarean section. Early presentation and timely decision to terminate pregnancy will improve the maternal and perinatal outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of maternal and perinatal morbidity and mortality in eclampsia by early termination of pregnancy

Mondal

Lahiri

2020

Int J Res Med Sci

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“…Every year, 50,000 women die from preeclampsia and its complications [ 3 ]. According to various authors, preeclampsia develops with a frequency of 2% to 10% of all pregnancies [ 4 , 5 , 6 ]. In 0.03–0.055%, it passes into eclampsia [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…In developed countries, it accounts for about 16–18% of maternal mortality and up to 40% of fetal and newborn deaths [ 10 ]. In women with preeclampsia, the rate of complications can reach 22% [ 4 ]. Preeclampsia is the main cause of preterm birth, intrauterine growth restriction, and perinatal mortality [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia

Korokin

Гуреев

Гудырев

et al. 2020

IJMS

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Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therapy. Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy. The administration of the pHBSP at the doses of 10 µg/kg and 250 µg/kg corrected the established morphofunctional disorders. The greatest effect was observed at a dose of 250 µg/kg. There was a decrease in systolic and diastolic blood pressure by 31.2 and 32.8%, respectively (p < 0.0001), a decrease in the coefficient of endothelial dysfunction by 48.6% (p = 0.0006), placental microcirculation increased by 82.8% (p < 0.0001), the NOx concentration was increased by 42,6% (p = 0.0003), the greater omentum edema decreased by 11.7% (p = 0.0005) and proteinuria decreased by 76.1% (p < 0.0002). In addition, there was an improvement in the morphological pattern of the fetoplacental complex and the ratio of BAX to Bcl-2 expression which characterizes the apoptotic orientation of the cells.

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“…В развитых странах на ее долю приходится около 16-18% случаев материнской смерти и до 40% случаев смерти плода и новорожденного [14]. У женщин с преэклампсией частота осложнений может достигать 22% [21]. Преэклампсия является основной причиной преждевременных родов, задержки внутриутробного развития и перинатальной смертности [17].…”

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Correction of functional disorders in ADMA-like preeclampsia with derivatives of the peptide imitating erythropoietin α-helix B

Владимирович¹,

Викторович²,

Владимирович³

et al. 2020

Kursk Scientific and Practical Bulletin “Man and His Health”

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Objective. The aim of the study is to investigate the correction of functional disorders in ADMA-like preeclampsia with derivatives of the peptide imitating erythropoietin α-helix B. Materials and methods. The study was performed in 120 white female Wistar rats weighing 250-300 g. ADMA-like preeclampsia was used as experimental preeclampsia. To assess the effectiveness of the pharmacological agents used, blood pressure, microcirculation in the placenta, and proteinuria were recorded, the content of final NO metabolites in the blood plasma was determined, and the coefficient of endothelial dysfunction was calculated. 50 μg / kg polypeptides (P-αB3 and P-αB4) were used as pharmacological agents, obtained by attaching to the original 11-amino acid peptide PHBSP [PubChem CID: 91810664], which is the amino acid chain Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (QEQLERALNSS) of KGD group from different ends of the chain. Results. The use of the studied derivatives of peptide imitating erythropoietin α-helix B with ADMA-like preeclampsia leads to a pronounced correction of disorders. The greatest effect was observed with the introduction of the peptide with the laboratory code P-αB4. A significant decrease in systolic and diastolic pressure was noted, respectively, improved microcirculation in the placenta, restoration of the NO-synthesizing function of the endothelium, and a decrease in proteinuria. Conclusion. The results obtained indicate the prospect of further research on the effectiveness of short-chain derivatives of erythropoietin imitating its α-helix B for the correction of functional disorders in preeclampsia.

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Maternal and Fetal Outcomes of Pregnancy-related Hypertensive Disorders in a Tertiary Care Hospital in Sukkur, Pakistan

Cited by 20 publications

References 14 publications

Evaluation of maternal and perinatal morbidity and mortality in eclampsia by early termination of pregnancy

Evaluation of maternal and perinatal morbidity and mortality in eclampsia by early termination of pregnancy

Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia

Correction of functional disorders in ADMA-like preeclampsia with derivatives of the peptide imitating erythropoietin α-helix B

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