Maternal and fetal indicators of oxidative stress in various obstetric complications

Abstract

The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born at~er premature rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05) as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high(p<0.01 ). In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation and proteolytic activity in maternal erythrocytes was significantly higher than in controls(p<0.001 and p<0o05 respectively). In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001 and p<0.05 respectively).

Effets antidiabétiques de l’extrait aqueux de <i>Ageratum conyzoïdes</i> (Astéraceae) chez les rats rendus diabétiques par pancréatectomie partielle et évaluation de leurs paramètres hématologiques

“…La chute de ces différents paramètres chez les rats témoins diabétiques pourrait être le résultat d'une anémie ou le début du processus de glycosylation observé chez les diabétiques (Rao et al, 2003). En effet une variation des paramètres hématologiques chez un sujet est synonyme d'une anomalie dans le fonctionnement, la morphologie ou le métabolisme des érythrocytes, des leucocytes et des plaquettes (Comazzi et al, 2004).…”

Hypoglycemic and hematological effects of aqueous extract of Thymus serpyllum Linn. in alloxan-induced diabetic rabbits

“…Thus, increased RBC count of T. serpyllum treated rabbits might be due to the lowered lipid peroxide level in RBCs membrane leading to a decrease susceptibility of RBCs to hemolysis. Moreover, reactive oxygen species has also been suggested to play role in the mechanism of red cells damage (Rao et al, 2003). So, the antioxidant effect of the T. serpyllum might provide the protection of RBCs against free radical damage.…”

Maternal and fetal indicators of oxidative stress during intrauterine growth retardation (IUGR)

“…We have previously reported increased lipid peroxidation and proteolytic activity in the erythrocytes of both mothers with gestational diabetes and their newborn infants (16) as well as during LSCS, premature rupture of membranes and prolonged second stage of labour (17). Often, fetuses born prematurely may have lowered antioxidant defenses (2).…”