2019
DOI: 10.3390/pathogens8010024
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Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group

Abstract: Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of the congenital infection may be severe for the unborn child. Fetal damage can range from asymptomatic to severe neurological alterations to retinal lesions prone to potential flare up and relapses lifelong. Despite the possible severity of outcome, congenital toxoplasmosis (CT) is a neglected disease. There is no consensus regarding screening during pregnancy, prenatal/postnatal treatment or short … Show more

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Cited by 113 publications
(100 citation statements)
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“…A positive T. gondii- specific IgM result during pregnancy suggests acute T. gondii infection, probably acquired after conception, and an associated risk of transplacental transmission. Previous maternal specimens, such as booking bloods, should be retrospectively tested; however, there are important caveats to interpretation, summarised in table 1 6 7 9–11. In equivocal cases, further testing should be undertaken either locally or at a national reference laboratory 6…”
Section: A Systematic Approach To Managementmentioning
confidence: 99%
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“…A positive T. gondii- specific IgM result during pregnancy suggests acute T. gondii infection, probably acquired after conception, and an associated risk of transplacental transmission. Previous maternal specimens, such as booking bloods, should be retrospectively tested; however, there are important caveats to interpretation, summarised in table 1 6 7 9–11. In equivocal cases, further testing should be undertaken either locally or at a national reference laboratory 6…”
Section: A Systematic Approach To Managementmentioning
confidence: 99%
“…Comparing serial blood results may demonstrate increasing antibody titres (IgM and/or IgG dye test) or confirm seroconversion during pregnancy (table 1). 6 7 9–12 If infection acquired before conception can be confirmed, the risk to the pregnancy from T. gondii is considered low (in immunocompetent women), that is, T. gondii- specific IgG positive, IgM negative, with or without high IgG avidity on booking or preconception bloods.…”
Section: A Systematic Approach To Managementmentioning
confidence: 99%
See 3 more Smart Citations