Maternal and congenital syphilis in selected Latin America and Caribbean countries: a multi-country analysis using data from the Perinatal Information System

Serruya, Suzanne Jacob; Durán, Pablo; Martínez, Gerardo; Romero, Mario; Caffé, Sonja; Alonso, Mónica; Silveira, Mariângela Freitas da

doi:10.1071/sh14191

Cited by 22 publications

(19 citation statements)

References 2 publications

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“…We attempted to measure the association of SBRs and maternal syphilis prevalence . However, as reported syphilis prevalence is closely related to access to the screening test, the obtained results did not seem to be plausible. We also tried to collect data on the country‐level prevalence of congenital anomalies, to explore its relation to SBR, but data were only reported for nine countries in Latin America .…”

Section: Discussionmentioning

confidence: 99%

Stillbirth rates in 20 countries of Latin America: an ecological study

Pingray

Althabe

Vazquez

et al. 2018

BJOG

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Section: Discussionmentioning

confidence: 99%

Stillbirth rates in 20 countries of Latin America: an ecological study

Pingray

Althabe

Vazquez

et al. 2018

BJOG

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“…The main surveillance systems in Brazil are the Sistema de Informação de Agravos de Notificação–Sinan (Notifiable Diseases Information System) and the Sistema de Informação de Mortalidade –SIM (Mortality Information System). However, quality flaws in the registration of CS cases and deaths hinder a reliable analysis of the problem [5], a situation that is also identified in other countries of Latin American and Caribbean [6]. Therefore, despite the magnitude of the problem, morbidity and mortality rates from this disease remain underreported [2,4].…”

Section: Introductionmentioning

confidence: 99%

Underreporting of Congenital Syphilis as a Cause of Fetal and Infant Deaths in Northeastern Brazil

et al. 2016

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IntroductionOf all syphilis-related pregnancy outcomes, fetal death is certainly the most common one, being directly related to the availability, accessibility and quality of prenatal care. The present study aimed to analyze the underreporting of fetal and infant deaths and other maternal factors associated with congenital syphilis (CS) death.MethodsThis cross-sectional study integrated data of infants that were diagnosed and/or died of CS from the Sistema de Informação de Agravos de Notificação–Sinan (Notifiable Diseases Information System) and the Sistema de Informação de Mortalidade–SIM (Mortality Information System) in Fortaleza, Northeastern Brasil to identify unreported cases of congenital syphilis. We assessed data during the period from 2007 to 2013.ResultsThe underreporting of CS as a cause of fetal or infant death increased from 41 to 415 cases (90.1%) during 2007–2013. Exactly 3,209 cases of CS were identified in Sinan and 6,578 deaths in SIM. After database linkage, we identified 382 cases that were reported in the SIM and SINAN databases consisting of 309 fetal deaths and 73 infant deaths related to CS. From the children notified at Sinan that born alive, 3.0% (78/2,542) died; Out of these, 39 (50.0%) were early and 25 (32.1%) were late neonatal deaths. The proportion of death by CS increased from 0.62 to 5.8 from 2007 to 2013. At logistic regression, the variable that maintained statistical significance with fetal and infant death outcomes was the presence of CS signs and/or symptoms at birth (OR = 3.20; IC 95% 1.54–6.62; p = 0.002).ConclusionsNeonatal and Infant deaths following CS-associated live births are underreported in Northeastern Brazil. Data base linkage identified unreported fetal and neonatal deaths due to CS leading to an increased awareness of fetal/infant mortality due to this infection.

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“…In all, 29.2% of the 414 fetal and infant deaths found in this study referred to cases of mothers with syphilis reported to the Sinan. This finding shows that syphilis is probably not being diagnosed during prenatal care [26] or that diagnosed cases are not being reported. The elimination of CS is possible if diagnosis and treatment are instituted in a timely manner.…”

Section: Discussionmentioning

confidence: 99%

Fetal and infant mortality of congenital syphilis reported to the Health Information System

Canto¹,

Araújo²,

Miranda³

et al. 2019

PLoS ONE

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BackgroundCongenital syphilis (CS) is a major cause of mortality in several countries, especially in Latin America and the Caribbean. This study aimed to analyze fetal and infant mortality of CS reported to the Health Information System in a State in Northeastern Brazil.Methods and resultsThis was a cross-sectional study that analyzed the deaths of CS from 2010 to 2014 through the linkage of the Mortality Information System (SIM) and the Notifiable Diseases Information System (Sinan). The Statistical Package for the Social Sciences (SPSS) version 23.0 was used to calculate the rates of Fetal, Perinatal, Neonatal (early and late), and Postneonatal Mortality. Simple linear regression was performed. Fisher's exact test or Pearson's chi-square test were used for comparison of proportions and Student's t-test was used for comparison of means.Of the 414 cases reported to the SIM as deaths possibly caused by CS, 44 (10.6%) presented CS as the underlying cause. From 2010 to 2014 the Infant Mortality Rate of CS was 16.3 per 100,000 live births (y = 0.65x + 14.33, R2 = 0.2338, p = 0.003). There was an 89.4% underreporting of deaths. Perinatal deaths and fetal deaths of CS accounted for 87.7% and 73.9% of total deaths, respectively.ConclusionsThe results of the study revealed a significant Fetal and Infant Mortality rate of CS and demonstrated the importance of using the linkage method in studies that involve the analysis of secondary data obtained from mortality and disease reporting systems. The underreporting of CS as a cause of fetal and infant mortality leads to unawareness of the reality of deaths from this disease, hindering the development of public policies aimed at its prevention.

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Maternal and congenital syphilis in selected Latin America and Caribbean countries: a multi-country analysis using data from the Perinatal Information System

Cited by 22 publications

References 2 publications

Stillbirth rates in 20 countries of Latin America: an ecological study

Stillbirth rates in 20 countries of Latin America: an ecological study

Underreporting of Congenital Syphilis as a Cause of Fetal and Infant Deaths in Northeastern Brazil

Fetal and infant mortality of congenital syphilis reported to the Health Information System

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