Maternal alcohol consumption and oral clefts: a meta-analysis

Yin, Xiaonan; Li, J.; Li, Y.; Zou, Shujuan

doi:10.1016/j.bjoms.2019.08.013

Cited by 22 publications

(20 citation statements)

References 32 publications

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“…However, there are few evidences supporting a role in the CP etiology (DeRoo et al, 2008;Sabbagh et al, 2015). A recent meta-analysis (Yin et al, 2019) concluded that there is no evidence of a correlation between moderate periconceptional alcohol consumption and the risk of both nonsyndromic CL/P and CP in infants. However, authors suggest that the potential risk of binge-drinking cannot be excluded, because of the heterogeneity of the threshold level for alcohol consumption in the different investigations and of the limited sample sizes of heavy drinker mother cohorts.…”

Section: Etiology Environmental Factorsmentioning

confidence: 99%

Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors

Martinelli

Palmieri

Scapoli

2020

Front. Cell Dev. Biol.

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The epithelial and mesenchymal cells involved in early embryonic facial development are guided by complex regulatory mechanisms. Any factor perturbing the growth, approach and fusion of the frontonasal and maxillary processes could result in orofacial clefts that represent the most common craniofacial malformations in humans. The rarest and, probably for this reason, the least studied form of cleft involves only the secondary palate, which is posterior to the incisive foramen. The etiology of cleft palate only is multifactorial and involves both genetic and environmental risk factors. The intention of this review is to give the reader an overview of the efforts made by researchers to shed light on the underlying causes of this birth defect. Most of the scientific papers suggesting potential environmental and genetic causes of non-syndromic cleft palate are summarized in this review, including genome-wide association and gene-environment interaction studies.

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Section: Etiology Environmental Factorsmentioning

confidence: 99%

Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors

Martinelli

Palmieri

Scapoli

2020

Front. Cell Dev. Biol.

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“…Since isolated orofacial clefts are thought to be of multifactorial origin (Mossey, Little, Munger, Dixon, & Shaw, 2009), the finding of so few cases (five with cleft palate, two with cleft lip, and zero CLP from 1980 to 2016, Table 2) may be attributed to a number of factors. These include an absence of susceptibility genes (Böhmer et al, 2013; Dixon, Marazita, Beaty, & Murray, 2011; Garg et al, 2014; Shi et al, 2012) and the major external influences such as active and passive smoking and alcohol (Hoyt et al, 2016; Yin, Li, Li, & Zou, 2019). The five cleft palate cases seen in the study years did not appear to belong to any syndrome.…”

Section: Discussionmentioning

confidence: 99%

Prevalence rates study of selected isolatednon‐Mendeliancongenital anomalies in the Hutterite population of Alberta, 1980–2016

Lowry

Bedard

Crawford

et al. 2020

American J of Med Genetics Pt A

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A study of the prevalence rates for selected isolated non-Mendelian congenital anomalies in the Hutterite Brethren of Alberta, Canada was undertaken to further examine longitudinal data in this isolated community that was last reported in 1985 (Lowry et al., 1985), although there are numerous publications on recessive disorders (Boycott et al., 2008; Triggs-Raine et al., 2016). Cases were ascertained from the Alberta Congenital Anomaly Surveillance System for the years 1997-2016. Since our initial results showed some surprising findings in the Hutterite Brethren, such as zero cases of spina bifida, cleft lip and palate, gastroschisis, and omphalocele, and a significant excess of cases with hypospadias, we extended the study to prior years (1980-1996) for selected anomalies. For the extended study period (1980-2016), there was a significant increased prevalence of hypospadias, tetralogy of Fallot and tricuspid atresia in the Hutterite population, and although not statistically significant, zero cases of cleft lip with cleft palate, gastroschisis and omphalocele were confirmed. Further research is needed to determine the precise effects of rural environmental exposures, lifestyle factors, and genetic associations for selected multifactorial congenital anomalies.

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“…Another recent study in Japan also observed no relationship between maternal drinking and OFC by two metrics: the mother quit drinking after pregnancy (OR = 0.87, 95% CI 0.63, 1.22) versus current drinker during pregnancy (OR = 0.71, 95% CI: 0.22, 2.27; Sato et al, 2020). Meta‐analysis by Yin et al similarly found no relationship between any drinking and CL/P (OR = 1.00, 95% CI: 0.87, 1.15) or CPO (OR = 1.02, 95% CI: 0.92, 1.14; Yin et al, 2019). However, some studies have identified an OFC risk related to alcohol consumption in China (OR = 1.79, 95% CI: 1.03, 3.12; D. P. Xu et al, 2018), Democratic Republic of the Congo (OR = 19.30, 95% CI: 1.89, 197.10; Mbuyi‐Musanzayi et al, 2018), and Mexico (OR = 1.90, 95% CI: 1.17, 3.08; Angulo‐Castro et al, 2017).…”

Section: Behavioral Risk Factors For Ofcsmentioning

confidence: 97%

“…Another possible hypoxic mechanism is through the depriving of oxygen from certain proteins with 2OG oxygenase domains that have been associated with OFCs, such as the lysine demethylase PHF8 (Loenarz et al, 2010). Polymorphism in another transcription factor involved in regulating TGF‐β during palatogenesis (Bjork, Turbe‐Doan, Prysak, Herron, & Beier, 2010), PRDM16 , was associated with OFCs and either active or passive smoking (Yin, Li, Li, & Zou, 2019). Variants of genes involved in detoxification have also been associated with tobacco smoke exposure and OFCs as previously discussed.…”

Section: Behavioral Risk Factors For Ofcsmentioning

confidence: 99%

Environmental mechanisms of orofacial clefts

Garland

Reynolds

Zhou

2020

Birth Defects Research

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Orofacial clefts (OFCs) are among the most common birth defects and impart a significant burden on afflicted individuals and their families. It is increasingly understood that many nonsyndromic OFCs are a consequence of extrinsic factors, genetic susceptibilities, and interactions of the two. Therefore, understanding the environmental mechanisms of OFCs is important in the prevention of future cases. This review examines the molecular mechanisms associated with environmental factors that either protect against or increase the risk of OFCs. We focus on essential metabolic pathways, environmental signaling mechanisms, detoxification pathways, behavioral risk factors, and biological hazards that may disrupt orofacial development.

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Maternal alcohol consumption and oral clefts: a meta-analysis

Cited by 22 publications

References 32 publications

Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors

Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors

Prevalence rates study of selected isolatednon‐Mendeliancongenital anomalies in the Hutterite population of Alberta, 1980–2016

Environmental mechanisms of orofacial clefts

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