Maternal age, reproduction and chromosomal aberrations in Wistar derived rats

Niggeschulze, A.; Kast, A

doi:10.1258/002367794781065717

Cited by 10 publications

(6 citation statements)

References 33 publications

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“…Female rats remain fertile as late as 18 months [38]; 11 months of age is considered middle-aged [39], although litter sizes decline [40] and fetal mortality increases with age [39]. The animals in the current study were between 7 and 9 months of age, well within middle-age, but still fertile.…”

Section: Discussionmentioning

confidence: 71%

Effects of Ovariectomy on Indices of Insulin Resistance, Hypertension, and Cardiac Energy Metabolism in Middle-Aged Spontaneously Hypertensive Rats (SHR)

2002

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Insulin resistance is a risk factor for coronary heart disease. The protection of young women from coronary events is sharply reduced with menopause. To assess the impact of menopause on glucose tolerance, insulin resistance, body weight gain, heart size, and cardiac energy metabolism, we studied 28-week-old female SHR and Wistar-Kyoto (WKY) rats, who were either ovariectomized (SHR(OVX) and WKY(OVX)) or sham-operated (SHR(SHAM) and WKY(SHAM)). Animals underwent blood-pressure measurement and an oral glucose tolerance test (OGTT). Hearts were weighed and assayed for metabolic enzyme activities. Female SHR were 33 % lighter and hypertensive (+ 36 mmHg), with 33 % larger hearts (when corrected for body weight differences) compared to WKY. Although ovariectomized animals of both strains were heavier overall than their sham-operated counterparts, when heart weights were corrected for body weight, both OVX strains had lighter hearts than both SHAM strains. Glucose and insulin responses during OGTT were similar between the four groups; however, free fatty acid (FFA) responses were approximately 50 % greater in SHR than WKY, although less in SHR(OVX) than SHR(SHAM). WKY(OVX) demonstrated 8 % lower ventricular hexokinase activity than WKY(SHAM), which may reflect reduced cardiac glucose utilization. We also noted 16 % higher citrate synthase activity in WKY hearts. In conclusion, the insulin resistance characteristic of younger SHR is blunted in middle-aged female rats, although FFA responses remain elevated. Ovariectomy did not alter in vivo glucose tolerance in this group; however, sex hormones may be important in maintaining normal heart size and the potential for cardiac glucose metabolism.

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Section: Discussionmentioning

confidence: 71%

Effects of Ovariectomy on Indices of Insulin Resistance, Hypertension, and Cardiac Energy Metabolism in Middle-Aged Spontaneously Hypertensive Rats (SHR)

2002

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“…It is well known that in the rat, ovulatory capacity and fertility are decreased from 8 to 10 months old and onward (Jones & Krohn 1961, Mattheij & Swarts 1991, Niggeschulze & Kast 1994, Chavez-Genaro et al 2007, Acuna et al 2009). This can be evaluated by counting the number of corpora lutea present in the ovary, the number of ovulated oocytes and the number of pups born per litter at different ages.…”

Section: Ovulation and Spontaneous Follicular Cyst Formation During Tmentioning

confidence: 98%

Ovarian function and reproductive senescence in the rat: role of ovarian sympathetic innervation

2017

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Successful reproduction is the result of a myriad interactions in which the ovary and the ovarian follicular reserve play a fundamental role. At present, women who delay maternity until after 30 years of age have a decreased fertility rate due to various causes, including damaged follicles and a reduction in the reserve pool of follicles. Therefore, the period just prior to menopause, also known as the subfertile period, is important. The possibility of modulating the follicular pool and the health of follicles during this period to improve fertility is worth exploring. We have developed an animal model to study the ovarian ageing process during this subfertile period to understand the mechanisms responsible for reproductive senescence. In the rat model, we have shown that the sympathetic nervous system participates in regulating the follicular development during ovarian ageing. This article reviews the existing evidence on the presence and functional role of sympathetic nerve activity in regulating the follicular development during ovarian ageing, with a focus on the subfertile period. Free Spanish abstract: A Spanish translation of this abstract is freely available at http://www.reproduction-online.org/content/153/2/ R59/suppl/DC1. Reproduction (2017) 153 R59-R68

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“…The second litter is usually the largest (Bennett and Vickery, 1970). After 9 months of age, litter size is further decreased, and the pregnancy rate declines after 12 months of age (Niggeschulze and Kast, 1994). Loss of fetuses, termed pregnancy wastage, occurs as a function of age (Mattheij and Swarts, 1991), with less than 5% wastage in 4-month-old rats, 30% in 9-month-old rats, and 65% at 11 months of age.…”

Section: Parturitionmentioning

confidence: 99%