Materials considerations of implantable neuroengineering devices for clinical use

Merrill, Daniel R.

doi:10.1016/j.cossms.2014.07.002

Cited by 20 publications

(16 citation statements)

References 54 publications

(44 reference statements)

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“…While BDD electrodes appear to be well-suited for acute neural interfacing applications, it remains unknown if chronically implanted BDD electrodes are able to efficiently record and/or activate neurons over time. An essential requirement to ensure a stable long-term performance in implantable neural devices is an interface that minimizes the healing response to implantation known as the foreign body reaction (Merrill, 2014 ). The presence of encapsulation tissue seriously compromises the quality of signals recorded from electrodes chronically implanted in the brain and peripheral nerves (Grill and Mortimer, 1994 ; Marin and Fernández, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Boron-Doped Nanocrystalline Diamond Electrodes for Neural Interfaces: In vivo Biocompatibility Evaluation

et al. 2016

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Boron-doped nanocrystalline diamond (BDD) electrodes have recently attracted attention as materials for neural electrodes due to their superior physical and electrochemical properties, however their biocompatibility remains largely unexplored. In this work, we aim to investigate the in vivo biocompatibility of BDD electrodes in relation to conventional titanium nitride (TiN) electrodes using a rat subcutaneous implantation model. High quality BDD films were synthesized on electrodes intended for use as an implantable neurostimulation device. After implantation for 2 and 4 weeks, tissue sections adjacent to the electrodes were obtained for histological analysis. Both types of implants were contained in a thin fibrous encapsulation layer, the thickness of which decreased with time. Although the level of neovascularization around the implants was similar, BDD electrodes elicited significantly thinner fibrous capsules and a milder inflammatory reaction at both time points. These results suggest that BDD films may constitute an appropriate material to support stable performance of implantable neural electrodes over time.

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Section: Introductionmentioning

confidence: 99%

Boron-Doped Nanocrystalline Diamond Electrodes for Neural Interfaces: In vivo Biocompatibility Evaluation

et al. 2016

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“…Most importantly, the platform has been fabricated using widely available processes, which allows for easy customization at a low cost. We are working to improve the design to eliminate undesirable materials and rely entirely on known biocompatible materials that are promising candidates for future approval by the FDA [16].…”

Section: Discussionmentioning

confidence: 99%

A low-cost, 61-channel µECoG array for use in rodents

Woods

Wang

Bossi

et al. 2015

2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)

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Micro-Electrocorticography (µECoG) offers a minimally invasive, high resolution interface with large areas of cortex. A wide variety of µECoG designs have been developed and customized [1]-[4], including active, multiplexed arrays [5] and arrays on dissolving substrates for increased conformal contact [6]. However, designing and fabricating customized µECoG arrays requires access to microfabrication facilities, which many neuroscience labs do not have. Microfabrication is also typically labor intensive and expensive. Commercial µECoG arrays with 64 electrodes and coarser dimensions cost approximately $1000, limiting their suitability for chronic implantation in large numbers of animals. Here we present a high density (406 µm spacing), flexible (~30 µm thin), 61-contact µECoG electrode array fabricated using a low-cost, commercial manufacturing process. The array costs just $26 when ordered in quantities of 100, with the cost per electrode increasing slightly when lower quantities are ordered. Fine pitch wires minimize the size of the interconnections, enabling chronic implantation in rodents. In-house post-processing of the fabricated µECoG arrays added optional electrode coatings, such as platinum black, to reduce the electrode impedance. Our electrode design and manufacturing process dramatically improves the accessibility and reduces the cost of highvolume, high-resolution neuroscience.

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“…CPs are usually applied in the form of the blends with nanomaterials, hydrogels, or elastomers, as on their own they are characterized by elastic moduli in the range of gigapascals and have tendency to delaminate under prolonged electrical stimulation. More detailed information about materials considerations in neural electrodes are provided in Hassler et al ( 2011 ), Fattahi et al ( 2014 ), Merrill ( 2014 ), and Scholten and Meng ( 2015 ).…”

Section: Requirements For the Design Of Intracortical Recording Electmentioning

confidence: 99%

Neural Interfaces for Intracortical Recording: Requirements, Fabrication Methods, and Characteristics

2017

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Implantable neural interfaces for central nervous system research have been designed with wire, polymer, or micromachining technologies over the past 70 years. Research on biocompatible materials, ideal probe shapes, and insertion methods has resulted in building more and more capable neural interfaces. Although the trend is promising, the long-term reliability of such devices has not yet met the required criteria for chronic human application. The performance of neural interfaces in chronic settings often degrades due to foreign body response to the implant that is initiated by the surgical procedure, and related to the probe structure, and material properties used in fabricating the neural interface. In this review, we identify the key requirements for neural interfaces for intracortical recording, describe the three different types of probes—microwire, micromachined, and polymer-based probes; their materials, fabrication methods, and discuss their characteristics and related challenges.

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Materials considerations of implantable neuroengineering devices for clinical use

Cited by 20 publications

References 54 publications

Boron-Doped Nanocrystalline Diamond Electrodes for Neural Interfaces: In vivo Biocompatibility Evaluation

Boron-Doped Nanocrystalline Diamond Electrodes for Neural Interfaces: In vivo Biocompatibility Evaluation

A low-cost, 61-channel µECoG array for use in rodents

Neural Interfaces for Intracortical Recording: Requirements, Fabrication Methods, and Characteristics

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Materials considerations of implantable neuroengineering devices for clinical use

Cited by 20 publications

References 54 publications

Boron-Doped Nanocrystalline Diamond Electrodes for Neural Interfaces: In vivo Biocompatibility Evaluation

Boron-Doped Nanocrystalline Diamond Electrodes for Neural Interfaces: In vivo Biocompatibility Evaluation

A low-cost, 61-channel &#x00B5;ECoG array for use in rodents

Neural Interfaces for Intracortical Recording: Requirements, Fabrication Methods, and Characteristics

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Product

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A low-cost, 61-channel µECoG array for use in rodents