Materials and Fractal Designs for 3D Multifunctional Integumentary Membranes with Capabilities in Cardiac Electrotherapy

Xu, Lizhi; Gutbrod, Sarah R.; Ma, Yinji; Petrossians, Artin; Wang, Kun; Webb, R. Chad; Fan, Jonathan A.; Yang, Zijian; Xu, Renxiao; Whalen, John J.; Weiland, James D.; Huang, Yonggang; Efimov, Igor R.; Rogers, John A.

doi:10.1002/adma.201405017

Cited by 145 publications

(123 citation statements)

References 32 publications

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“…skin-like prosthesis 9-13 , biomimetic robots 14-17 , etc. ), or to integrate with biological tissues/organs (such as epidermal electronics 18-24 , flexible implantable medical instruments 25-28 , etc. ).…”

Section: Introductionmentioning

confidence: 99%

Design and application of ‘J-shaped’ stress–strain behavior in stretchable electronics: a review

Feng

et al. 2017

Lab Chip

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140

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A variety of natural biological tissues (e.g., skin, ligaments, spider silk, blood vessel) exhibit ‘J-shaped’ stress-strain behavior, thereby combining soft, compliant mechanics and large levels of stretchability, with a natural ‘strain-limiting’ mechanism to prevent damage from excessive strain. Synthetic materials with similar stress-strain behaviors have potential utility in many promising applications, such as tissue engineering (to reproduce the nonlinear mechanical properties of real biological tissues) and biomedical devices (to enable natural, comfortable integration of stretchable electronics with biological tissues/organs). Recent advances in this field encompass developments of novel material/structure concepts, fabrication approaches, and unique device applications. This review highlights five representative strategies, including designs that involve open network, wavy and wrinkled morphoologies, helical layouts, kirigami and origami constructs, and textile formats. Discussions focus on the underlying ideas, the fabrication/assembly routes, and the microstructure-property relationships that are essential for optimization of the desired ‘J-shaped’ stress-strain responses. Demonstration applications provide examples of the use of these designs in deformable electronics and biomedical devices that offer soft, compliant mechanics but with inherent robustness against damage from excessive deformation. We conclude with some perspectives on challenges and opportunities for future research.

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Section: Introductionmentioning

confidence: 99%

Design and application of ‘J-shaped’ stress–strain behavior in stretchable electronics: a review

Feng

et al. 2017

Lab Chip

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140

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“…For example, the balloon catheter reported by Kim et al is a multifunctional device that can measure various properties such as electrical properties, thermal properties, pH, temperature, and mechanical strain [36]. This device's electrodes consist of a fractal structure, which allows high density sensing over a large area and low impedance without compromising elasticity and compliance [37]. Xu et al [36] demonstrated a cardiac model with a 3D printer and created an elastic membrane called 3D multifunctional integumentary membranes (3D-MIM) as shown in Fig.…”

Section: Multifunctional Devicementioning

confidence: 99%

“…4, Xu et al [37] also reported an actuator capable of not only sensing but also electrical stimulation. This device has an array of 8 electrodes located around the heart circumference and it was able to deliver spatially and temporality programmed electrical stimulation onto the heart outside membrane [37].…”

Section: Multifunctional Devicementioning

confidence: 99%

“…The reported results showed 4 An image attached to the outer wall of the rabbit heart with an elastic membrane containing a multifunctional sensor capable of providing electrical stimulation (the white arrows indicate the electrodes of the sensor and the fractal structure) (Reproduced with permission from Ref. [37], © 2015 WILEY VCH Verlag GmbH & Co. KGaA, Weinheim) that the average heart rate of pigs was 120 bpm and the aorta had a strain rate of about 10% due to heartbeat [49][50][51]. The instantaneous output of the PG was 30 nW and lasted for 700 ms and was charged to 1.0 V for 40 s for a 1 μF capacitor in the charge test [49].…”

Section: Generatormentioning

confidence: 99%

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A review: flexible, stretchable multifunctional sensors and actuators for heart arrhythmia therapy

Kang¹,

Pak

2017

Micro and Nano Syst Lett

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Cardiovascular disease is a very serious disease which results in about 30% of all global mortality. Atrial fibrillation (AF) causes rapid and irregular contractions resulting in stroke and cardiac arrest. AF is caused by abnormality of the heartbeat controlling electrical signal. Catheter ablation (CA) is often used to treat and remove the abnormal electrical source from the heart but it has limitations in sensing capability and spatial coverage. To overcome the limitations of the CA, new devices for improving the spatial capability have been reported. One of the most impressive methods is wrapping the heart surface with a flexible/stretchable film with an array of high-density multifunctional micro-sensors and actuators. With this technique, the overall heart surface may be diagnosed in real time and the AF may be treated much more effectively. The data acquisition from the array of multifunctional sensors is also very important for making the new devices useful. To operate the implanted device system, a battery is mostly used and it should be avoided to replace the battery by surgery. Therefore, various energy harvesting techniques or wireless energy transfer techniques to continuously feed the power to the system are under investigation. The development of these technologies was reviewed, and the current level of technology was reviewed and summarized.

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“…However, to reach their full potential in the field of healthcare, autonomous biomedical systems To be easily used ex vivo and in vivo, future autonomous biomedical systems will need to be wearable and implantable. In order to achieve this, they will need to be fully flexible to fit the shape of organs, 6 including skin, closely. 11,12 Thus, the devices will be more discrete and comfortable, which is important for the patient, and will be better adapted to their target, which will increase their sensing ability and the amount of energy harvested.…”

Section: Outlook and Future Challengesmentioning

confidence: 99%

Wearable and Implantable Mechanical Energy Harvesters for Self-Powered Biomedical Systems

2015

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In this issue of ACS Nano, Tang et al. investigate the ability of a triboelectric nanogenerator (TENG) to self-power a low-level laser cure system for osteogenesis by studying the efficiency of a bone remodeling laser treatment that is powered by a skin-patch-like TENG instead of a battery. We outline this field by highlighting the motivations for self-powered biomedical systems and by discussing recent progress in nanogenerators. We note the overlap between biomedical devices and TENGs and their dawning synergy, and we highlight key prospects for future developments. Biomedical systems should be more autonomous. This advance could improve their body integration and fields of action, leading to new medical diagnostics and treatments. However, future self-powered biomedical systems will need to be more flexible, biocompatible, and biodegradable. These advances hold the promise of enabling new smart autonomous biomedical systems and contributing significantly to the Internet of Things.

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Materials and Fractal Designs for 3D Multifunctional Integumentary Membranes with Capabilities in Cardiac Electrotherapy

Cited by 145 publications

References 32 publications

Design and application of ‘J-shaped’ stress–strain behavior in stretchable electronics: a review

Design and application of ‘J-shaped’ stress–strain behavior in stretchable electronics: a review

A review: flexible, stretchable multifunctional sensors and actuators for heart arrhythmia therapy

Wearable and Implantable Mechanical Energy Harvesters for Self-Powered Biomedical Systems

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