Material-specific binding peptides empower sustainable innovations in plant health, biocatalysis, medicine and microplastic quantification

Mao, Maochao; Ahrens, Leon; Luka, Julian; Contreras, Francisca; Kurkina, Tetiana; Bienstein, Marian; Sárria Pereira de Passos, Marisa; Schirinzi, Gabriella; Mehn, Dora; Valsesia, Andrea; Desmet, Cloé; Serra, Miguel-Ángel; Gilliland, Douglas; Schwaneberg, Ulrich

doi:10.1039/d2cs00991a

Chem. Soc. Rev.

2024

DOI: 10.1039/d2cs00991a

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Material-specific binding peptides empower sustainable innovations in plant health, biocatalysis, medicine and microplastic quantification

Maochao Mao,

Leon Ahrens,

Julian Luka

et al.

Abstract: Overview of natural and engineered material-binding peptides and the molecular forces crucial for their (material-specific) binding to material surfaces.

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Cited by 3 publications

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The spatial separation of basic amino acids is similar in RHAMM and hyaluronan binding peptide P15‐1 despite different sequences and conformations

Erkanli,

Kang,

Kirsch

et al. 2024

Proteoglycan Research

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Peptides that increase pro‐reparative responses to injury and disease by modulating the functional organization of hyaluronan (HA) with its cell surface binding proteins (e.g., soluble receptor for hyaluronan‐mediated motility [RHAMM] and integral membrane CD44) have potential therapeutic value. The binding of RHAMM to HA is an attractive target, since RHAMM is normally absent or expressed at low levels in homeostatic conditions, but its expression is significantly elevated in the extracellular matrix during tissue stress, response‐to‐injury, and in cancers and inflammation‐based diseases. The HA‐binding site in RHAMM contains two closely spaced sequences of clustered basic amino acids, in an alpha‐helical conformation. In the present communication, we test whether an alpha‐helical conformation is required for effective peptide binding to HA, and competitive disruption of HA–RHAMM interaction. The HA‐binding RHAMM‐competitive peptide P15‐1, identified using the unbiased approach of phage display, was examined using circular dichroism spectroscopy and the conformation‐predictive AI‐based AlphaFold2 algorithm. Unlike the HA‐binding site in RHAMM, peptide P15‐1 was found to adopt irregular conformations in solution rather than alpha helices. Instead, our structural analysis suggests that the primary determinant of peptide‐HA binding is associated with a specific clustering and spacing pattern of basic amino acids, allowing favorable electrostatic interaction with carboxylate groups on HA.

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The spatial separation of basic amino acids is similar in RHAMM and hyaluronan binding peptide P15‐1 despite different sequences and conformations

Erkanli,

Kang,

Kirsch

et al. 2024

Proteoglycan Research

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Selective on-site detection and quantification of polystyrene microplastics in water using fluorescence-tagged peptides and electrochemical impedance spectroscopy

Motalebizadeh,

Fardindoost,

Hoorfar

2024

Journal of Hazardous Materials

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Development of a Finishing Process for Imbuing Flame Retardancy into Materials Using Biohybrid Anchor Peptides

Heesemann,

Sanders,

Paul

et al. 2024

Applied Sciences

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Flame retardants are commonly used to reduce fire risk in various products and environments, including textiles. While many of these additives contain harmful substances, efforts are underway to reduce their usage. Current research aims to minimize flame-retardant quantities and enhance durability against external factors. This involves utilizing anchor peptides or material-binding peptides (MBPs), which are versatile molecules that bind strongly to surfaces like textiles. MBPs can be equipped with functional molecules, e.g., flame-retardant additives, by chemical or enzymatic bioconjugation. In this research, biohybrid flame retardants and an adapted finishing process are developed. Specifically, biobased adhesion promoters, the so-called MBPs, are used to finish textiles with flame-retardant additives. To date, there is no finishing process for treating textiles with MBPs and so a laboratory-scale finishing process based on foulard was developed. Necessary parameters, such as the take-off speed or the contact pressure of the squeezing rollers, are determined experimentally. In order to develop an adapted finishing process, various trials are designed and carried out. Part of the trials is the testing and comparison of different textiles (e.g., glass woven fabrics and aramid woven fabrics) under different conditions (e.g., different ratios of MBPs and flame retardants). The finished textiles are then analysed and validated regarding their flammability and the amount of adhered flame retardants.

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Material-specific binding peptides empower sustainable innovations in plant health, biocatalysis, medicine and microplastic quantification

Abstract: Overview of natural and engineered material-binding peptides and the molecular forces crucial for their (material-specific) binding to material surfaces.

Cited by 3 publications

References 680 publications

The spatial separation of basic amino acids is similar in RHAMM and hyaluronan binding peptide P15‐1 despite different sequences and conformations

The spatial separation of basic amino acids is similar in RHAMM and hyaluronan binding peptide P15‐1 despite different sequences and conformations

Selective on-site detection and quantification of polystyrene microplastics in water using fluorescence-tagged peptides and electrochemical impedance spectroscopy

Development of a Finishing Process for Imbuing Flame Retardancy into Materials Using Biohybrid Anchor Peptides

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