The spatial separation of basic amino acids is similar in RHAMM and hyaluronan binding peptide P15‐1 despite different sequences and conformations
Mehmet Emre Erkanli,
Ted Keunsil Kang,
Thorsten Kirsch
et al.
Abstract:Peptides that increase pro‐reparative responses to injury and disease by modulating the functional organization of hyaluronan (HA) with its cell surface binding proteins (e.g., soluble receptor for hyaluronan‐mediated motility [RHAMM] and integral membrane CD44) have potential therapeutic value. The binding of RHAMM to HA is an attractive target, since RHAMM is normally absent or expressed at low levels in homeostatic conditions, but its expression is significantly elevated in the extracellular matrix during t… Show more
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