Material properties and cell compatibility of poly(γ-glutamic acid)-keratin hydrogels

Bajestani, Maryam Ijadi; Kader, Safaa; Monavarian, Mehri; Mousavi, Seyyed Mohammad; Jabbari, Esmaiel; Jafari, Arezou

doi:10.1016/j.ijbiomac.2019.10.020

Cited by 26 publications

(13 citation statements)

References 42 publications

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“…Taken together, through the rational design of self-assembly proteins, the mechanical strength of recombinant keratin hydrogels could be regulated by the fabrication of robust keratin hydrogels. Compared with the reported pure keratin, ,− collagen, − silk, − and gelatin hydrogels, − our designed recombinant keratin hydrogels exhibited outstanding storage and compressive modulus, which were also comparable to or higher than that of most composited and chemically modified keratin hydrogels (Figure M). ,− …”

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confidence: 68%

Bioinspired Robust Keratin Hydrogels for Biomedical Applications

et al. 2022

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Although keratins are robust in nature, hydrogels producing their extracts exhibit poor mechanical properties due to the complicated composition and ineffective self-assembly. Here we report a bioinspired strategy to fabricate robust keratin hydrogels based on mechanism study through recombinant proteins. Homotypic and heterotypic self-assembly of selected type I and type II keratins in different combinations was conducted to identify crucial domain structures for the process, their kinetics, and relationship with the mechanical strength of hydrogels. Segments with best performance were isolated and used to construct novel assembling units. The new design outperformed combinations of native proteins in mechanical properties and in biomedical applications such as controlled drug release and skin regeneration. Our approach not only elucidated the critical structural domains and underlying mechanisms for keratin selfassembly but also opens an avenue toward the rational design of robust keratin hydrogels for biomedical applications.

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confidence: 68%

Bioinspired Robust Keratin Hydrogels for Biomedical Applications

et al. 2022

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“…Therefore, the biocompatible materials used (in this research, PLA and composites) should also have relevant properties, such as hydrophilic surfaces, wettability, and non‐toxic effects 59 . PLA and keratin, alone or in combination with other biomaterials, have shown generally good compatibility with cells and tissues 60–64 . Figure 7 shows the proliferation, adhesion, and viability of fibroblasts cells on materials after 24 h cultures.…”

Section: Resultsmentioning

confidence: 99%

Additive manufacturing of green composites: Poly (lactic acid) reinforced with keratin materials obtained from Angora rabbit hair

Flores-Hernández

Velasco‐Santos

Rivera‐Armenta

et al. 2020

J of Applied Polymer Sci

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In this research, additive manufacturing of polylactic acid (PLA) reinforced with keratin was studied. Keratin was obtained from Angora rabbit hair and modified with NaOH. Scanning electron microscopy (SEM) images showed that the modified surfaces were rougher than untreated surfaces. Furthermore, SEM images in the composites' fracture regions showed surface changes, associated with the nature of the reinforcement. Likewise, thermomechanical properties of the composites were attributed to the nature of the reinforcement and the type of keratin. Besides, the 3D printed composites showed higher thermal conductivity values than PLA with the addition of keratin. Cytotoxicity tests revealed an improvement in cell growth compared to the control and PLA. These results are meaningful toward the development of high thermal conductors and biocompatible composites with applications in different fields, where the use of only natural polymers is necessary.

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“…A hydrogel is a hydrophilic chain formed by physical and chemical interactions and absorbs water from the surrounding solvent environment during self-assembly; a network polymer with high water content is formed. Hydrogels have good water retention and swelling ratios and a three-dimensional structure, similar to that of human nerve tissue [43].…”

Section: Polypeptide Hydrogel Repairs Peripheral Nerve Injurymentioning

confidence: 94%

“…and swelling ratios and a three-dimensional structure, similar to that of human nerve tissue [43]. They can be used as an excellent potential matrix for cultivating nerve cells and can simulate the microenvironment of nerve tissue cytoplasmic matrix [44].…”

Section: Ph Controlmentioning

confidence: 99%

Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides

Zhang

et al. 2021

Gels

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Peripheral nerve injury often occurs in young adults and is characterized by complex regeneration mechanisms, poor prognosis, and slow recovery, which not only creates psychological obstacles for the patients but also causes a significant burden on society, making it a fundamental problem in clinical medicine. Various steps are needed to promote regeneration of the peripheral nerve. As a bioremediation material, self-assembled peptide (SAP) hydrogels have attracted international attention. They can not only be designed with different characteristics but also be applied in the repair of peripheral nerve injury by promoting cell proliferation or drug-loaded sustained release. SAP hydrogels are widely used in tissue engineering and have become the focus of research. They have extensive application prospects and are of great potential biological value. In this paper, the application of SAP hydrogel in peripheral nerve injury repair is reviewed, and the latest progress in peptide composites and fabrication techniques are discussed.

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Material properties and cell compatibility of poly(γ-glutamic acid)-keratin hydrogels

Cited by 26 publications

References 42 publications

Bioinspired Robust Keratin Hydrogels for Biomedical Applications

Bioinspired Robust Keratin Hydrogels for Biomedical Applications

Additive manufacturing of green composites: Poly (lactic acid) reinforced with keratin materials obtained from Angora rabbit hair

Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides

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