Material and tablet properties of pregelatinized (thermally modified) Dioscorea starches

Odeku, Oluwatoyin A.; Schmid, Wolfgang P.; Picker‐Freyer, Katharina M.

doi:10.1016/j.ejpb.2008.04.011

Cited by 49 publications

(32 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural D. dumetorum and D. oppositifolia starches were found to be highly compressible and formed tablets of acceptable crushing force while natural D. alata and D. rotundata starches did not form intact tablets except at high compression pressures indicating that the natural forms of D. dumetorum and D. oppositifolia starches could be useful as excipients in tablet formulation by direct compression [6]. These four yam starches when modified by pregelatinization, acid modification, cross-linking, and hydroxypropylation exhibited different properties indicating their potentials for different applications in drug formulation [18][19][20]. The pregelatinized forms of the starches exhibited improved compressibility and flowability than the natural forms of the starches indicating their potential usefulness in direct compression [18,21] while the pregelatinized freeze dried forms of D. dumetorum and D. oppositifolia starches produced tablets which were non-disintegrating the indicating potential application as excipients for controlled drug delivery [18].…”

Section: Yamsmentioning

confidence: 99%

“…The authors concluded that modified D. dumetorum and D. oppositifolia starches could find application as excipients for controlled drug delivery [21]. Furthermore, tablets prepared with acid modified and hydroxypropylated forms of the starches from the Dioscorea species were also shown to exhibit fast disintegration in direct compression indicating that they could be useful as disintegrants in tablet formulations, while others -pregelatinized, freeze-dried, and cross-linked -showed high bond strength with potentials of being useful as binding agents [18][19][20]. The acid modified forms of D. alata and D. rotundata starches have also been shown to possess better disintegrant efficiency than the Natural forms of the starches and corn starch in paracetamol tablet formulations [22].…”

Section: Yamsmentioning

confidence: 99%

“…These four yam starches when modified by pregelatinization, acid modification, cross-linking, and hydroxypropylation exhibited different properties indicating their potentials for different applications in drug formulation [18][19][20]. The pregelatinized forms of the starches exhibited improved compressibility and flowability than the natural forms of the starches indicating their potential usefulness in direct compression [18,21] while the pregelatinized freeze dried forms of D. dumetorum and D. oppositifolia starches produced tablets which were non-disintegrating the indicating potential application as excipients for controlled drug delivery [18].…”

Section: Yamsmentioning

confidence: 99%

“…The potentials of natural and modified forms of starches from the four different Dioscorea species were also evaluated as direct compression excipients in tablet formulations [6,[18][19][20]. Natural D. dumetorum and D. oppositifolia starches were found to be highly compressible and formed tablets of acceptable crushing force while natural D. alata and D. rotundata starches did not form intact tablets except at high compression pressures indicating that the natural forms of D. dumetorum and D. oppositifolia starches could be useful as excipients in tablet formulation by direct compression [6].…”

Section: Yamsmentioning

confidence: 99%

See 3 more Smart Citations

Potentials of tropical starches as pharmaceutical excipients: A review

Odeku

2012

Starch Stärke

100

View full text Add to dashboard Cite

Tropical roots and tubers, grains, cereals, and fruits are crops that have served as staple foods for millions of people throughout the hot and humid regions of the world for many centuries. Some of these crops grow in abundance with little or no artificial input. These tropical crops contain starch of as one their major component, which has made them good sources of starch that could be used as pharmaceutical excipients. In recent time, some of these starches have been investigated for use as fillers, glidants, binders, and disintegrants in pharmaceutical tablet formulations. The diversity of the starches from these plants has shown that some of the starches can be used in place of commercially available chemically modified starches. Their application as excipients can add value to some of these neglected and underutilized crops and also provide starch with special properties for specific applications. This review summarizes the present knowledge on the starches extracted from tropical plants that have been evaluated as pharmaceutical excipients and their potential usefulness, with a view to providing suggestions for needed research to adopt the utilization of these starches in the pharmaceutical industry.

show abstract

Section: Yamsmentioning

confidence: 99%

Section: Yamsmentioning

confidence: 99%

Section: Yamsmentioning

confidence: 99%

Section: Yamsmentioning

confidence: 99%

See 2 more Smart Citations

Potentials of tropical starches as pharmaceutical excipients: A review

Odeku

2012

Starch Stärke

100

View full text Add to dashboard Cite

show abstract

“…time involving fewer unit operations and suitable for heat or moisture sensitive active pharmaceutical ingredients (API) (Odeku et al, 2008;Ogunjimi and Alebiowu 2013;Olowosulu et al, 2011). The burden of formulating poorly compressible drugs into robust tablets by DC is borne largely by the excipients utilized in this operation.…”

Section: Research Articlementioning

confidence: 99%

Comparative analysis of co-processed starches prepared by three different methods

Apeji¹,

Aluga²,

Olayemi³

et al. 2017

British Journal of Pharmacy

View full text Add to dashboard Cite

Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that cogranulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of coprocessing influences the powder and tableting properties of the co-processed excipient.

show abstract

Material properties of partially pregelatinized cassava starch prepared by mechanical activation

et al. 2013

View full text Add to dashboard Cite

This study has focused on the preparation of partially pregelatinized cassava starch (PPCS) by mechanical activation (MA) using a customized stirring ball mill. The changes in degree of gelatinization, crystal structure, particle size, surface morphology, powder characteristics, and pasting properties of cassava starch mechanically activated for different time were investigated by various characterizations. The results showed that MA could significantly destroy the crystal structure of starch granules, contributing to the increase of cold-water solubility, flowability, and floodability, the variations of particle size and surface morphology, and the decrease in pasting temperature, viscosity of cooked PPCS paste, breakdown, and setback. It was also found that the PPCS with different degree of gelatinization could be prepared by controlling the milling time. With the unique properties induced by MA, the potential use of PPCS as excipient in pharmaceutical formulations is discussed.

show abstract

Material and tablet properties of pregelatinized (thermally modified) Dioscorea starches

Cited by 49 publications

References 27 publications

Potentials of tropical starches as pharmaceutical excipients: A review

Potentials of tropical starches as pharmaceutical excipients: A review

Comparative analysis of co-processed starches prepared by three different methods

Material properties of partially pregelatinized cassava starch prepared by mechanical activation

Contact Info

Product

Resources

About