Comparative analysis of co-processed starches prepared by three different methods

Abstract

Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that cogranulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of coprocessing influences the powder and tableting properties of the co-processed excipient.

Impact of binder as a formulation variable on the material and tableting properties of developed co-processed excipients

“…Similarly, a study carried out by Wang et al (2015) demonstrated an improvement in the tabletability of lactose when co-processed with hydroxypropyl methylcellulose (HPMC E3) and crospovidone (PVPP). Other studies related to improving the direct compression potential of starches has been achieved by co-processing with binders like acacia [14,15]. In the present study, two co-processed excipients composed of tapioca starch and colloidal silicon dioxide but differing in the binder content were generated by co-fusion.…”

Evaluation of Co-Processed Excipients for Fast Disintegration of Aspirin Tablets Prepared by Direct Compression

“…Uniformity in weight of tablets has been attributed to the uniform flow of the formulation mix during the filling of the die leading to compression. This is crucial since poor flow will result in a large range in tablet weight, which could negatively affect the consistency of the tablets' contents and may lead to inconsistent bioavailability of the active ingredient (Apeji et al, 2017).…”