Matched-Pair Analysis of Conformal High–Dose-Rate Brachytherapy Boost Versus External-Beam Radiation Therapy Alone for Locally Advanced Prostate Cancer

Kestin, Larry L.; Martínez, Álvaro; Stromberg, Jannifer S.; Edmundson, Gregory K.; Gustafson, Gary; Brabbins, D.; Chen, Peter Y.; Vicini, Frank A.

doi:10.1200/jco.2000.18.15.2869

Cited by 109 publications

(45 citation statements)

References 81 publications

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“…Also, in a matched-pair analysis that compared Յ 74 Gy Ͼ 74 Gy by Hanks et al, 15 RT dose was associated significantly with DM and cause-specific death for patients who were matched for iPSA, Gleason score, and T stage. Kestin et al 16 also did a matched-pair analysis and found that higher biologic RT doses were associated with reduced OM; however, those authors did not find any relation of dose with DM or cause-specific death. In one of the few studies wherein MVA was performed, Valicenti et al 17 found that RT dose was an independent predictor of cause-specific death and OM for patients who had Gleason scores of 8 -10.…”

Section: Discussionmentioning

confidence: 97%

“…9 -11 Moreover, direct evidence that RT dose reduces DM or OM has not been conclusive. 3,[12][13][14][15][16][17] In the current report, the association of RT dose to DM and OM was examined in a population of men with prostate carcinoma who were treated relatively uniformly with three-dimensional (3D)-conformal RT. Because, over the period of the study (1989 -1997), stage migration 18 -21 and Gleason score shift [22][23][24] occurred, both of which complicate retrospective analyses of treatment changes over time, the year of treatment (YOT) was included as a covariate.…”

Section: Resultsmentioning

confidence: 99%

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The relationship of increasing radiotherapy dose to reduced distant metastases and mortality in men with prostate cancer

Jacob

Hanlon

Horwitz

et al. 2004

Cancer

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A coupled simulation of the flue gas and process gas side of the convection section of a steam cracker is performed, making use of the CFD software package Fluent. A detailed overview of the operating mode of the different heat exchangers suspended in the convection section is obtained. The asymmetric inlet flow field of the flue gas in the convection section, and the radiation from the convection section walls leads to large differences in outlet temperatures of the tubes located in the same row. The flow fields and temperature fields in the tubes of a single heat exchanger differ significantly with e.g., outlet temperatures of the hydrocarbon‐steam mixture ranging from 820 K to 852 K. Moreover, the simulations reveal the presence of hot spots on the lowest tube row, possibly causing fouling. © 2009 American Institute of Chemical Engineers AIChE J, 2009

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Section: Discussionmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

The relationship of increasing radiotherapy dose to reduced distant metastases and mortality in men with prostate cancer

Jacob

Hanlon

Horwitz

et al. 2004

Cancer

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“…[121][122][123][124][125] We restricted our analysis to use only the RCT data on biochemical relapse and frequency of adverse events.…”

Section: Case Study 1: Full Guideline Model For Prostate Cancermentioning

confidence: 99%

Economic modelling of diagnostic and treatment pathways in National Institute for Health and Care Excellence clinical guidelines: the Modelling Algorithm Pathways in Guidelines (MAPGuide) project

Lord

Willis²,

Eatock³

et al. 2013

Health Technology Assessment

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“…Increasingly, conformal radiation delivery techniques have safely escalated the dose to the prostate by either increasing the number of daily fractions [1][2][3] or adding a boost [4][5][6][7]. These approaches increase the delivered bioequivalent dose (BED), and consequently the biochemical control rate, but are associated with additional treatment time or, in the case of a brachytherapy boost, an invasive procedure.…”

Section: Introductionmentioning

confidence: 99%

Hypofractionated SBRT Versus Conventionally Fractionated EBRT for Prostate Cancer: Comparison of PSA Slope and Nadir

Anwar

Weinberg

Chang

et al. 2013

International Journal of Radiation Oncology*Biology*Physics

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Background: Patients with early stage prostate cancer have a variety of curative radiotherapy options, including conventionally-fractionated external beam radiotherapy (CF-EBRT) and hypofractionated stereotactic body radiotherapy (SBRT). Although results of CF-EBRT are well known, the use of SBRT for prostate cancer is a more recent development, and long-term follow-up is not yet available. However, rapid post-treatment PSA decline and low PSA nadir have been linked to improved clinical outcomes. The purpose of this study was to compare the PSA kinetics between CF-EBRT and SBRT in newly diagnosed localized prostate cancer. Materials/methods: 75 patients with low to low-intermediate risk prostate cancer (T1-T2; GS 3 + 3, PSA < 20 or 3 + 4, PSA < 15) treated without hormones with CF-EBRT (>70.2 Gy, <76 Gy) to the prostate only, were identified from a prospectively collected cohort of patients treated at the University of California, San Francisco (1997. Patients were excluded if they failed therapy by the Phoenix definition or had less than 1 year of follow-up or <3 PSAs. 43 patients who were treated with SBRT to the prostate to 38 Gy in 4 daily fractions also met the same criteria. PSA nadir and rate of change in PSA over time (slope) were calculated from the completion of RT to 1, 2 and 3 years post-RT.

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Matched-Pair Analysis of Conformal High–Dose-Rate Brachytherapy Boost Versus External-Beam Radiation Therapy Alone for Locally Advanced Prostate Cancer

Abstract: Locally advanced prostate cancer patients treated with EBRT + HDR demonstrate improved biochemical control compared with those who are treated with conventional doses of EBRT alone.

Cited by 109 publications

References 81 publications

The relationship of increasing radiotherapy dose to reduced distant metastases and mortality in men with prostate cancer

The relationship of increasing radiotherapy dose to reduced distant metastases and mortality in men with prostate cancer

Economic modelling of diagnostic and treatment pathways in National Institute for Health and Care Excellence clinical guidelines: the Modelling Algorithm Pathways in Guidelines (MAPGuide) project

Hypofractionated SBRT Versus Conventionally Fractionated EBRT for Prostate Cancer: Comparison of PSA Slope and Nadir

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