Mast Cells--Their Presence and Ultrastructural Characteristics in Peripheral Nerve Tumors

Pineda, Anselmo

doi:10.1001/archneur.1965.00470040038006

Cited by 34 publications

(8 citation statements)

References 18 publications

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“…Additional studies have since supported the finding of mast cells in peripheral nerve trunks (10,11), peripheral nerve tumors (12)(13)(14), and neurofibromas in neurofibromatosis 1 (15)(16)(17). The potential involvement of the c-Kit receptor and its ligand (18,19) in the formation of neurofibromas has also been reported, but Yang et al (2) are the first investigators to evaluate living cells of different genetic backgrounds in order to demonstrate how increased mast cells populate neurofibromas.…”

Section: Mast Cells and Neurofibromasmentioning

confidence: 98%

It takes two to tango: mast cell and Schwann cell interactions in neurofibromas

Viskochil¹

2003

J. Clin. Invest.

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Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. (see the related article beginning on page 1851) dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann cells. These results set the stage for rational development of therapeutics that could influence the multicellular microenvironment of neurofibromas to inhibit the development and/or progression of these tumors in human NF1.

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Section: Mast Cells and Neurofibromasmentioning

confidence: 98%

It takes two to tango: mast cell and Schwann cell interactions in neurofibromas

Viskochil¹

2003

J. Clin. Invest.

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“…Independent groups later reported the existence of mast cells within peripheral nerve sheaths, nerve sheath tumors, and NF1-associated neurofibromas [27][28][29][30][31]. Further histological analyses have shown significant increases of mast cell number in only the neurofibroma tissue, as compared to surrounding tissue [32].…”

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confidence: 99%

The Plexiform Neurofibroma Microenvironment

Yang

Staser

2012

Cancer Microenvironment

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Dynamic interactions between tumorigenic cells and surrounding cells, including immunomodulatory hematopoietic cells, can dictate tumor initiation, progression, and transformation. Hematopoietic-stromal interactions underpin the plexiform neurofibroma, a debilitating tumor arising in individuals afflicted with Neurofibromatosis type 1 (NF1), a common genetic disorder resulting from mutations in the NF1 tumor suppressor gene. At the tissue level, plexiform neurofibromas demonstrate a complex microenvironment composed of Schwann cells, fibroblasts, perineural cells, mast cells, secreted collagen, and blood vessels. At the cellular level, specific interactions between these cells engender tumor initiation and progression. In this microenvironment hypothesis, tumorigenic Schwann cells secrete pathological concentrations of stem cell factor, which recruit c-kit expressing mast cells. In turn, activated mast cells release inflammatory effectors stimulating the tumorigenic Schwann cells and their supporting fibroblasts and blood vessels, thus promoting tumor expansion in a feed-forward loop. Bone marrow transplantation experiments in plexiform neurofibroma mouse models have shown that tumorigenesis requires Nf1 haploinsufficiency in the hematopoietic compartment, suggesting that tumor microenvironments can depend on intricate interactions at both cellular and genetic levels. Overall, our continued understanding of critical tumor-stromal interactions will illuminate novel therapeutic targets, as shown by the first-ever successful medical treatment of a plexiform neurofibroma by targeted inhibition of the stem cell factor/c-kit axis.

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“…Numerous mast cells may be seen in the stroma. [8] Ideally renal masses of 4 cm or small especially originating in the poles of the kidney and amenable to partial nephrectomy are preferred to be treated with nephron sparing approach. It avoids unnecessary nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

Neurofibroma of kidney: An uncommon neoplasm and diagnostic dilemma with solitary fibrous tumor

et al. 2010

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Neurofibroma of kidney is an extremely rare tumor. To our knowledge, only five such cases have been reported worldwide till date. Here, we report a solitary neurofibroma of right kidney in a 54-year-old woman. Radiological investigations (ultrasonography and computed tomography) detected a solid mass in the upper pole of right kidney and clinicoradiologically renal cell carcinoma was suspected. A radical nephrectomy was performed under diagnosis of cancer. Microscopically, tumor consisted of benign spindle-shaped cells accompanied by fibrous tissue. Differential diagnoses of neurofibroma and solitary fibrous tumor (SFT) were made on morphological features. Immunohistochemically, the tumor cells were positive for S-100 protein, but negative for CD34 and CD99. Thus, a diagnosis of neurofibroma was established.

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Mast Cells--Their Presence and Ultrastructural Characteristics in Peripheral Nerve Tumors

Cited by 34 publications

References 18 publications

It takes two to tango: mast cell and Schwann cell interactions in neurofibromas

It takes two to tango: mast cell and Schwann cell interactions in neurofibromas

The Plexiform Neurofibroma Microenvironment

Neurofibroma of kidney: An uncommon neoplasm and diagnostic dilemma with solitary fibrous tumor

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