Mast cells influence neoangiogenesis in prostatic cancer independently of ERG status

Miłek, Katarzyna; Kaczmarczyk-Sekuła, Karolina; Strzępek, Aleksandra; Dyduch, Grzegorz; Białas, Magdalena; Szpor, Joanna; Gołąbek, Tomasz; Szopiński, Tomasz; Chłosta, Piotr; Okoń, Krzysztof

doi:10.5114/pjp.2016.62027

Cited by 5 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, the immunological response seems to be worth investigating, and it has already been proposed to use tumor vaccines in prostate cancer [15]. Proper understanding of immunological processes is crucial, as many components of the tumor microenvironment, including macrophages, different classes of lymphocytes, NK cells, plasma cells, neutrophils, eosinophils and mast cells, participate in the immune response [16,17,18,19].…”

Section: Discussionmentioning

confidence: 99%

Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Kaczmarczyk-Sekuła¹,

Gałązka²,

Glajcar³

et al. 2016

pjp

Self Cite

View full text Add to dashboard Cite

Prostatic carcinoma is the most frequent cancer in males in the Western world. A significant proportion of these cancers have a recurrent translocation involving ETS family genes, which leads to the overexpression of ERG transcription factor. Prostate cancers, which bear this mutation, differ in a number of features, including tumor microenvironment. One of the components of the tumor microenvironment is FOXP3 positive lymphocytes, which may participate in breaking immunosurveillance and promoting tumor growth. 2 for all cases, 21.43/ mm 2 for the ERG negative and 42.28/mm 2 for the ERG positive group (p < 0.02). There were no significant relationships between FOXP3 positive cell count and any other parameters studied. Our results suggest that the immune response may differ between ERG negative and ERG positive prostatic carcinomas.

show abstract

Section: Discussionmentioning

confidence: 99%

Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Kaczmarczyk-Sekuła¹,

Gałązka²,

Glajcar³

et al. 2016

pjp

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although a number of studies were published on the subject, it is still unclear whether translocation-associated prostate cancers are different in morphology or behavior [15]. In our opinion, some differences exist in terms of both morphology and stage as well as interaction with the tumor microenvironment [3,16,17,18]. KDM1A, CHD1, and androgen receptor were identified as forming a complex responsible for targeted DNA breaks, which lead to TMPRSS2-ETS translocation [19].…”

Section: Discussionmentioning

confidence: 99%

Image analysis discloses differences in nuclear parameters between ERG+ and ERG– prostatic carcinomas

Okoń¹,

Dyduch²,

Białas³

et al. 2020

pjp

Self Cite

View full text Add to dashboard Cite

Prostatic carcinoma (PC) is the most frequent urologic cancer and one of the most frequent cancers in males; it is a heterogeneous disease, in terms of molecular features, morphology and prognosis. About half of cases depends on TMPRSS2-ETS translocation which leads to a production of ERG transcription factor. ERG+ and ERG-cancers seem to differ in a number of features, which could lead to an altered nuclear structure; the aim of the study was to test this hypothesis. The material consisted of total 39 PC cases, representing ERG+ and ERG-, as well as Gleason pattern 3 and 4. Filtering by color deconvolution and automatic segmentation were used, and the properly detected nuclei were manually selected. From each case fifty nuclei were obtained; then geometric features and texture parameters were assessed. The analysis of the collected data showed differences both between ERG+/ERG-and Gleason pattern 3 and 4 cases in most of the features analyzed. Our results suggest that indeed the ERG status, thus likely TMPRSS2-ETS translocation, has an impact on morphology of nuclei in PC, and their differences are evident enough to be detectable by image analysis.

show abstract

“…Mast cells (MCs) are enriched in the tumor microenvironment and clinical and experimental studies have confirmed that MCs can promote the occurrence and development of tumors ( Milek et al, 2016 ; Yamashita et al, 2017 ). Mast cell mediators and histamine and histamine receptors may influence the growth of HCC cells, and mast cells and histamine play different roles according to the characteristics of tumor cells ( Lampiasi et al, 2007 ).…”

Section: The Role Of Mast Cells In Liver Cancermentioning

confidence: 99%

Exploring the role of mast cells in the progression of liver disease

Huang

Luo

et al. 2022

Front. Physiol.

View full text Add to dashboard Cite

In addition to being associated with allergic diseases, parasites, bacteria, and venoms, a growing body of research indicates that mast cells and their mediators can regulate liver disease progression. When mast cells are activated, they degranulate and release many mediators, such as histamine, tryptase, chymase, transforming growth factor-β1 (TGF-β1), tumor necrosis factor–α(TNF-α), interleukins cytokines, and other substances that mediate the progression of liver disease. This article reviews the role of mast cells and their secretory mediators in developing hepatitis, cirrhosis and hepatocellular carcinoma (HCC) and their essential role in immunotherapy. Targeting MC infiltration may be a novel therapeutic option for improving liver disease progression.

show abstract

Mast cells influence neoangiogenesis in prostatic cancer independently of ERG status

Cited by 5 publications

References 23 publications

Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Image analysis discloses differences in nuclear parameters between ERG+ and ERG– prostatic carcinomas

Exploring the role of mast cells in the progression of liver disease

Contact Info

Product

Resources

About