Exploring the role of mast cells in the progression of liver disease

Huang, Shizhuan; Wu, Haotian; Luo, Feng; Zhang, Bin; Li, Tianwei; Yang, Zongrui; Ren, Biao; Yin, Wenze; Wu, Dehai; Tai, Sheng

doi:10.3389/fphys.2022.964887

Cited by 11 publications

(6 citation statements)

References 104 publications

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“…The results of our study also revealed that the HRG, characterized by a poor prognosis, exhibited elevated levels of macrophage M0 infiltration. In addition, mast cells can facilitate the onset and progression of HCC by increasing the population of immunosuppressive cells, resulting in a poor prognosis ( 64 ). In our study, we found that the HRG had a lower proportion of mast cells in a resting state.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of immune-related gene signature models for predicting prognosis and immunotherapy response in hepatocellular carcinoma

Liu,

Yang,

Liu

et al. 2024

Front. Immunol.

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BackgroundThis study seeks to enhance the accuracy and efficiency of clinical diagnosis and therapeutic decision-making in hepatocellular carcinoma (HCC), as well as to optimize the assessment of immunotherapy response.MethodsA training set comprising 305 HCC cases was obtained from The Cancer Genome Atlas (TCGA) database. Initially, a screening process was undertaken to identify prognostically significant immune-related genes (IRGs), followed by the application of logistic regression and least absolute shrinkage and selection operator (LASSO) regression methods for gene modeling. Subsequently, the final model was constructed using support vector machines-recursive feature elimination (SVM-RFE). Following model evaluation, quantitative polymerase chain reaction (qPCR) was employed to examine the gene expression profiles in tissue samples obtained from our cohort of 54 patients with HCC and an independent cohort of 231 patients, and the prognostic relevance of the model was substantiated. Thereafter, the association of the model with the immune responses was examined, and its predictive value regarding the efficacy of immunotherapy was corroborated through studies involving three cohorts undergoing immunotherapy. Finally, the study uncovered the potential mechanism by which the model contributed to prognosticating HCC outcomes and assessing immunotherapy effectiveness.ResultsSVM-RFE modeling was applied to develop an OS prognostic model based on six IRGs (CMTM7, HDAC1, HRAS, PSMD1, RAET1E, and TXLNA). The performance of the model was assessed by AUC values on the ROC curves, resulting in values of 0.83, 0.73, and 0.75 for the predictions at 1, 3, and 5 years, respectively. A marked difference in OS outcomes was noted when comparing the high-risk group (HRG) with the low-risk group (LRG), as demonstrated in both the initial training set (P <0.0001) and the subsequent validation cohort (P <0.0001). Additionally, the SVMRS in the HRG demonstrated a notable positive correlation with key immune checkpoint genes (CTLA-4, PD-1, and PD-L1). The results obtained from the examination of three cohorts undergoing immunotherapy affirmed the potential capability of this model in predicting immunotherapy effectiveness.ConclusionsThe HCC predictive model developed in this study, comprising six genes, demonstrates a robust capability to predict the OS of patients with HCC and immunotherapy effectiveness in tumor management.

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Section: Discussionmentioning

confidence: 99%

Identification and validation of immune-related gene signature models for predicting prognosis and immunotherapy response in hepatocellular carcinoma

Liu,

Yang,

Liu

et al. 2024

Front. Immunol.

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“…Mast cell activation and degranulation were among the highest upregulated GOBP terms. Interestingly, recent studies suggested that mast cells play a significant role in the progression of various liver diseases ( 47 ). The major proteins driving liver inflammation in Lal−/− mice included PLD3, ANXA1, and CHIL3.…”

Section: Discussionmentioning

confidence: 99%

Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase

I¹,

Liesinger²,

Kuentzel³

et al. 2023

Journal of Lipid Research

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“…These cells express multiple PRRs that allow them to respond to diverse stimuli and release several cytokines, such as TNF-α, TGF-β, and ILs. MCs can lead to microvesicular steatosis, ductal reaction, biliary senescence, inflammation, angiogenesis, and liver fibrosis during MAFLD/NAFLD/NASH [ 67 ] ( Fig. 1 ).…”

Section: Innate-like T Cellsmentioning

confidence: 99%