Mast cells in viral infections

Witczak, Piotr; Brzezińska‐Błaszczyk, Ewa

doi:10.5604/17322693.991610

Cited by 11 publications

(7 citation statements)

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“…These cells influence the regulation of body homeostasis by acting on wound healing, angiogenesis and vascular permeability as well as take part in the homeostasis of tissues and organs that undergo continuous growth and remodelling . Mast cells play a prominent role in the host response to invading pathogens, such as bacteria or viruses and participate in innate and acquired immune mechanisms .…”

Section: Mast Cell Characteristicsmentioning

confidence: 99%

Mast cells participate in chronic low‐grade inflammation within adipose tissue

et al. 2018

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Obesity is reckoned as one of the civilization diseases, posing a considerable global health issue. Evidence points towards a contribution of multitude immune cell populations in obesity pathomechanism and the development of chronic low-grade inflammation in the expanded adipose tissue. Notably, adipose tissue is a reservoir of mast cells which number in individuals with obesity particularly increased. Some of them tend to degranulation what generate secretion of strong pro-inflammatory and regulatory mediators, as well as cytokines/chemokines. Several lines of evidence suggest that mast cells are strictly associated with pro-inflammatory status in adipose tissue by their indirect impact on immune cell attraction and activation. Furthermore, mast cells affect adipose tissue remodelling and fibrosis by adipocyte differentiation, fibroblast proliferation and enhancing extracellular matrix proteins expression. This review will summarize current knowledge on mast cell features and their role in the development of chronic low-grade inflammation within adipose tissue.

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Section: Mast Cell Characteristicsmentioning

confidence: 99%

Mast cells participate in chronic low‐grade inflammation within adipose tissue

et al. 2018

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“…Activation of mast cells and increased levels of urinary histamine, which is a major product of mast cells were observed in dengue patients and the levels correlated with disease severity [ 25 ]. Several data indicated that virus stimulated mast cells selectively produced and secreted a variety of mediators including chemokines, cytokines, lipid mediators, and granule associated products.…”

Section: Immune Activation Markers As Predictors Of Severe Dengue Dismentioning

confidence: 99%

Biomarkers of severe dengue disease – a review

2015

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Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in affected individuals. The early prediction of severe dengue in patients without any warning signs who may later develop severe DHF is very important to choose appropriate intensive supportive therapy since available vaccines for immunization are yet to be approved. Severe dengue responses include T and B cell activation and apoptosis, cytokine storm, hematologic disorders and complement activation. Cytokines, complement and other unidentified factors may transiently act on the endothelium and alter normal fluid barrier function of the endothelial cells and cause plasma leakage. In this review, the host factors such as activated immune and endothelial cells and their products which can be utilized as biomarkers for severe dengue disease are discussed.

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“…Nowadays, more and more data indicate that mast cells are critical component of host defence against a variety of microorganisms, mainly bacteria [8] and viruses [9]. The role of these cells in protection against fungal infections is less understandable.…”

Section: Introductionmentioning

confidence: 99%

Expression of surface and intracellular Toll-like receptors by mature mast cells

Agier¹,

Żelechowska²,

Kozłowska³

et al. 2016

cejoi

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Nowadays, more and more data indicate that mast cells play an important role in host defense against pathogens. That is why it is essential to understand the expression of Toll-like receptors (TLRs) by mast cells, because these molecules play particularly significant role in initiation host defense against microorganisms as they recognize both wide range of microbial pathogen-associated molecular patterns (PAMPs) and various endogenous damage-associated molecular patterns (DAMPs) released in response to infection. Therefore, we examined the constitutive expression of both surface and endosomal TLRs in rat native fully mature tissue mast cells. By the use of qRT-PCR we found that these cells express mRNAs for TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9. The expression of TLR3, TLR4, TLR5, TLR7, and TLR9 transcripts were low and comparable and only the expression of TLR2 transcript was significant. By the use of flow cytometry technique, we clearly documented that mast cells express TLR2, TLR4, and TLR5 on cell surface, while TLR3, TLR7, and TLR9 proteins are located both on the cell membrane and intracellularly. The highest expression was observed for TLR5 and the lowest for surface TLR7. These observations undoubtedly indicate that mature tissue mast cells have a broad set of TLR molecules, thus can recognize and bind bacterial, viral, and fungal PAMPs as well as various endogenous molecules generated in response to infection.

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Mast cells in viral infections

Cited by 11 publications

References 0 publications

Mast cells participate in chronic low‐grade inflammation within adipose tissue

Mast cells participate in chronic low‐grade inflammation within adipose tissue

Biomarkers of severe dengue disease – a review

Expression of surface and intracellular Toll-like receptors by mature mast cells

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