Mast cells in rheumatic disease

Suurmond, Jolien; Velden, Daniël van der; Kuiper, Johan; Bot, Ilze; Toes, René E. M.

doi:10.1016/j.ejphar.2015.03.085

Cited by 21 publications

(34 citation statements)

References 109 publications

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“…In contrast to basophils, human mast cells are a factory of a plethora of cytokines such as SCF, TNF‐α, IL‐1β, IL‐3, IL‐5, IL‐6, IL‐9, IL‐10, IL‐11, IL‐13, IL‐16, IL‐22, IL‐25/IL‐17E, GM‐CSF, VEGFs, FGF‐2, NGF, amphiregulin, and TSLP . Mast cells were found to be a cell type producing IL‐17A in patients with inflammatory skin and joint diseases .…”

Section: Mediators Produced By Mast Cells and Basophilsmentioning

confidence: 99%

Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

125

116

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Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory responses. However, a closer understanding of their precise roles in allergies and other pathological conditions has been marred by the considerable heterogeneity that these cells display, not only between mast cells and basophils themselves but also across different tissue locations and species. While both cell types share the ability to rapidly degranulate and release histamine following high-affinity IgE receptor cross-linking, they differ markedly in their ability to either react to other stimuli, generate inflammatory eicosanoids or release immunomodulating cytokines and chemokines. Furthermore, these cells display considerable pharmacological heterogeneity which has stifled attempts to develop more effective anti-allergic therapies. Mast cell- and basophil-specific transcriptional profiling, at rest and after activation by innate and adaptive stimuli, may help to unravel the degree to which these cells differ and facilitate a clearer understanding of their biological functions and how these could be targeted by new therapies.

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Section: Mediators Produced By Mast Cells and Basophilsmentioning

confidence: 99%

Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

125

116

View full text Add to dashboard Cite

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“…They are present in the synovial membrane (SM) and have been implicated in contributing to the inflammatory response in several rheumatic diseases,3 including rheumatoid arthritis (RA) 4. Notably, MCs are present in healthy synovia,5 but their number significantly increases accompanying the cellular hyperplasia characteristic of RA synovitis 6–8.…”

Section: Introductionmentioning

confidence: 99%

Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production

et al. 2018

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“…Finally, MCs are thought to be partly responsible for drastic tissue remodeling occurring in RA. MCs are often found in the vicinity of blood synovial vessels and MC-mediators (VEGF, tryptase, chymase) are known to be potent angiogenic factors [35]. Matrix metalloproteinases (MMPs) secretion and osteoclasts activation responsible for cartilage breakdown and bone erosion, two hallmarks of RA, could be considered as consequence of MCs mediators' release.…”

Section: Mast Cells and Rheumatoid Arthritismentioning

confidence: 99%