Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases

Murdaca, Giuseppe; Allegra, Alessandro; Tonacci, Alessandro; Musolino, Caterina; Ricciardi, L; Gangemi, Sebastiano

doi:10.3390/biomedicines10081877

Cited by 16 publications

(12 citation statements)

References 125 publications

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“…The mechanism that provides rationale for the link between vitamin D and the risk of LBP remains ambiguous. One the one hand, vitamin D is recognized to induce changes in bone metabolism and could regulate the inflammatory cytokines that control pain (Xu et al, 2021;Murdaca et al, 2022). On the other hand, vitamin D deficiency deeply influences the microbiome by altering the microbiome composition and the integrity of the gut epithelial barrier (Murdaca et al, 2021a).…”

Section: Discussionmentioning

confidence: 99%

Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study

Tang

Kong

et al. 2023

Front. Microbiol.

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BackgroundPrevious studies have implicated a vital association between gut microbiota/gut microbial metabolites and low back pain (LBP), but their causal relationship is still unclear. Therefore, we aim to comprehensively investigate their causal relationship and identify the effect of gut microbiota/gut microbial metabolites on risk of LBP using a two-sample Mendelian randomization (MR) study.MethodsSummary data from genome-wide association studies (GWAS) of gut microbiota (18,340 participants), gut microbial metabolites (2,076 participants) and LBP (FinnGen biobank) were separately obtained. The inverse variance-weighted (IVW) method was used as the main MR analysis. Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) and MR-Egger regression were conducted to evaluate the horizontal pleiotropy and to eliminate outlier single-nucleotide polymorphisms (SNPs). Cochran’s Q-test was applied for heterogeneity detection. Besides, leave-one-out analysis was conducted to determine whether the causal association signals were driven by any single SNP. Finally, a reverse MR was performed to evaluate the possibility of reverse causation.ResultsWe discovered that 20 gut microbial taxa and 2 gut microbial metabolites were causally related to LBP (p < 0.05). Among them, the lower level of family Ruminococcaceae (OR: 0.771, 95% CI: 0.652–0.913, FDR-corrected p = 0.045) and Lactobacillaceae (OR: 0.875, 95% CI: 0.801–0.955, FDR-corrected p = 0.045) retained a strong causal relationship with higher risk of LBP after the Benjamini–Hochberg Corrected test. The Cochrane’s Q test revealed no Heterogeneity (p > 0.05). Besides, MR-Egger and MR-PRESSO tests showed no significant horizontal pleiotropy (p > 0.05). Furthermore, leave-one-out analysis confirmed the robustness of MR results. After adding BMI to the multivariate MR analysis, the 17 gut microbial taxa exposure-outcome effect were significantly attenuated and tended to be null.ConclusionOur findings confirm the the potential causal effect of specific gut microbiota and gut microbial metabolites on LBP, which offers new insights into the gut microbiota-mediated mechanism of LBP and provides the theoretical basis for further explorations of targeted prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study

Tang

Kong

et al. 2023

Front. Microbiol.

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“…These markers aid in identifying and characterizing mast cells in different tissues and body fluids, contributing to diagnostic assessments and disease monitoring. [ 17 , 18 ] Tryptase, a protease stored in mast cell granules, is 1 of the most widely used markers for mast cell identification. Elevated levels of tryptase in serum or tissues are indicative of mast cell activation and are often measured to diagnose systemic mastocytosis, a rare disorder characterized by abnormal mast cell proliferation.…”

Section: Mast Cell Markers and Diagnostic Utilitymentioning

confidence: 99%

Diagnostic and prognostic significance of mast cell markers in HIV/AIDS: Current insights and future directions

Obeagu

2024

Medicine

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Human immunodeficiency virus (HIV) infection continues to pose significant global health challenges, necessitating advancements in diagnostic and prognostic approaches to optimize disease management. While primarily recognized for their roles in allergic responses, mast cells have emerged as potential markers with diagnostic and prognostic significance in the context of HIV/AIDS. This paper aims to synthesize current insights and delineate future directions regarding the utility of mast cell markers in diagnosing HIV infection, predicting disease progression, and guiding therapeutic strategies. Mast cells, equipped with distinct markers such as tryptase, chymase, carboxypeptidase A3, and c-kit/CD117 receptors, exhibit tissue-specific expression patterns that offer potential as diagnostic indicators for HIV infection. Understanding the dynamics of these markers in different tissues and body fluids holds promise for accurate HIV diagnosis, disease staging, and monitoring treatment responses. Moreover, the prognostic significance of mast cell markers in HIV/AIDS lies in their potential to predict disease progression, immune dysregulation, and clinical outcomes. The integration of mast cell markers into clinical applications offers promising avenues for refining diagnostic assays, patient monitoring protocols, and therapeutic strategies in HIV/AIDS. Future research directions involve the development of novel diagnostic tools and targeted therapies based on mast cell-specific markers, potentially revolutionizing clinical practice and enhancing patient care in the management of HIV/AIDS. Continued investigations into mast cell markers’ diagnostic and prognostic implications hold immense potential to advance our understanding and improve outcomes in HIV/AIDS management.

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“…Продемонстрирована устойчивость тучных клеток благодаря витамину D и их высокая активация в условиях дефицита витамина D [51]. Установлено, что тучные клетки могут активно трансформировать 25(OH)D в 1,25(ОН) 2 D, что сопровождается снижением собственной экспрессии провоспалительных медиаторов [51].…”

Section: бронхопульмонология и отоларингологияunclassified

Vitamin D supply, respiratory viral infections and persistent wheezing in children: how significant is the relationship?

Barycheva,

Dolbnya,

Tolkunova

et al. 2024

Medicinskij sovet

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The review discusses the multifaceted effect of vitamin D on antiviral immunity, induction of antimicrobial peptides, functional activity of immunocompetent cells, autophagy processes, clearance of viruses and viral fragments. The relationship between vitamin D and allergic inflammatory cells, its modulating and tolerogenic potential is considered. The inhibitory effect of vitamin D on eosinophils, mast cells, the production of pro-inflammatory and proallergic mediators, and the synthesis of IgE has been shown. The protective role of vitamin D in the development of remodeling and hyperresponsiveness of the respiratory tract has been established by reducing the number of goblet cells, mucus hypersecretion, and the expression of metalloproteinases. The effects of vitamin D on the replication of respiratory viruses and experimental resistance to them through the induction of antimicrobial peptides and other mechanisms have been demonstrated. Data from clinical studies on the preventive effect of vitamin D on the incidence of respiratory infections and episodes of persistent wheezing in children are presented. Children with respiratory syncytial infection and vitamin D deficiency were more likely to require respiratory support and mechanical ventilation. The preventive role of vitamin D in the development of obstructive bronchitis in children and severe bronchiolitis in infants has been shown. It has been established that normal levels of 25(OH)D in the mother significantly reduce the risk of developing bronchial obstruction in the child. Alternative data that do not support a protective effect of vitamin D on respiratory morbidity and wheezing in children are discussed. Further monitoring studies that take into account geographic location and analysis of the dose of cholecalciferol used to assess its preventive role in the development of wheezing and bronchial asthma in children are advisable.

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Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases

Cited by 16 publications

References 125 publications

Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study

Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study

Diagnostic and prognostic significance of mast cell markers in HIV/AIDS: Current insights and future directions

Vitamin D supply, respiratory viral infections and persistent wheezing in children: how significant is the relationship?

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