Mast cells and human hepatocellular carcinoma

Combination of peritumoral mast cells and T‐regulatory cells predicts prognosis of hepatocellular carcinoma

“…In the present study, we also found that the intratumoral MCs infiltrations had no prognostic significance for HCC patients. This result is in line with a previous report, ( 45 ) and is similar to the study carried out by Hoshida and his colleagues which proved that gene expression signature correlated with survival is present in liver tissue adjacent to rather than within the tumor in patients with HCC. ( 5 ) However, the results of intratumoral MCs were not contrary to those of peritumoral MCs because we found that intratumoral MCs had the same prognostic trend as that of peritumoral MCs (i.e.…”

Retrospective study of cytologic features of well‐differentiated hepatocellular carcinoma in dogs

“…Scattered mast cells may be observed when hepatic fibrosis, found in almost half of the samples from WD‐HCC, is present . Mast cells also play a critical role in tumor neoangiogenesis and may be important in the transition from sinusoidal to capillary‐type hepatic endothelial cells . Cirrhosis has been reported in canine HCC, but was not correlated with histologic type .…”

Increased liver mast cell recruitment in patients with chronic C virus‐related hepatitis and histologically documented steatosis

“…Two further histological sections were used for immunohistochemistry: one section was treated for 1 h at room temperature with primary antibodies raised against human monoclonal mouse anti‐leucocyte common antigen (LCA; Dako, Milan, Italy) in order to recognize the whole inflammatory cell set [24], or 1 mg/mL mouse IgG1 (Dako) as a negative control; the other was immersed in a bath for antigen retrieval for 30 min at 98 °C in a freshly made 1 m m EDTA solution and used to identify MCs labelled with primary antibodies raised against human tryptase (Dako) [25], or 1 mg/mL mouse IgG1 (Dako) as a negative control.…”