Combination of peritumoral mast cells and T‐regulatory cells predicts prognosis of hepatocellular carcinoma

Abstract. Mast cells (MCs) and regulatory T cells (Tregs)are the important components of the inflammatory infiltrating leukocytes in most malignant tumors. Our study was designed to investigate the infiltrating correlation between MCs and Tregs and clarify their prognostic significance in gastric cancer (GC). A total of 60 fresh GC tissues were collected and tumor-infiltrating leukocytes were isolated by gradient centrifugation. Tryptase and Foxp3 were used as markers for MCs and Tregs, respectively. The expression of tryptase and Foxp3 was determined in tumor-infiltrating leukocytes using flow cytometry. The expression of tryptase and Foxp3 were positively correlated. The increased infiltration of MCs correlated significantly with advanced stage of GC. The infiltration of MCs into the tumor may increase the number of Tregs. Tryptase is a promising marker to stratify GC patients into different risk groups.

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“…Studies in liver cancer reported similar results (32). Numerous researchers consider IL-9 to be critical factor in this interaction (24)(25)(26).…”

Section: Discussionsupporting

confidence: 64%

Increased numbers of gastric-infiltrating mast cells and regulatory T cells are associated with tumor stage in gastric adenocarcinoma patients

Zhao

Cai

et al. 2012

Oncology Letters

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“…The peritumoral tissue, which contained a significant amount of leukocyte infiltration, was long assumed to represent the host response to the malignancy and had the significance of prognostic value in HCC (Ju et al, 2009;Kuang et al, 2009;Kuang et al, 2010;Liao et al, 2013). In current study, the most important new conclusion was that less counts of γδ T cells in peritumoral liver tissue were related to a higher incidence of recurrence in HCC patients after curative resection.…”

Section: Discussionsupporting

confidence: 49%

“…Our previous reports supported the relations between various immune cells (including regulatory T cells (Gao et al, 2007), memory T cells (Gao et al, 2012), dendritic cells (Cai et al, 2006), neutrophils (Li et al, 2011), mast cells (Ju et al, 2009), and activated hepatic stellate cells (Liao et al, 2013) in tumoral or peritumoral tissues with different survival outcomes. Our previous study also showed that the percentage of γδ T cells in HCC was reduced in tumor compared with peritumoral tissues and advanced tumor had even lower infiltration of γδ T cells, indicating the importance of γδ T cells in the antitumor immunity (Yi et al, 2013a).…”

Section: Discussionmentioning

confidence: 71%

Low Counts of γδ T Cells in Peritumoral Liver Tissue are Related to More Frequent Recurrence in Patients with Hepatocellular Carcinoma after Curative Resection

Cai

Wang²,

Yi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Interestingly, when counts of tryptase-positive MCs and Treg cells are combined, the outcome of patients can be predicted more effectively, confirming the close relationship between these two immunological parameters (Lu et al, 2006;Ju et al, 2009). Therefore, tryptase-positive MCs and Treg lymphocytes are promising prognostic parameters that could be used jointly to identify groups of patients with distinct outcomes.…”

Section: Discussionsupporting

confidence: 48%

Treatment with interleukin-2 in malignant pleural mesothelioma: immunological and angiogenetic assessment and prognostic impact

et al. 2009

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BACKGROUND: Administration of interleukin-2 (IL-2) has shown some effects on malignant pleural mesothelioma (MPM) tumour regression. The purpose of this study was to investigate the ability of IL-2 to modify immunological effector cells and angiogenesis in MPM patients and their prognostic value. METHODS: Tumour-infiltrating lymphocytes (CD4, CD8, Foxp3), mast cells (MCs) (tryptase and chymase), microvessel count (MVC) and VEGF were determined by immunohistochemistry in two series of MPM patients: 60 patients treated with intra-pleural preoperative IL-2 and 33 patients untreated. RESULTS: Tryptase MCs, and CD8 and Foxp3 lymphocytes were significantly increased in the IL-2-treated group, whereas MVC was significantly lower in the same group. Moreover, in the IL-2-treated group, greater tryptase þ MCs and greater Foxp3 lymphocytes were associated with improved and poorer clinical outcomes, respectively. Notably, when these two immunological parameters were combined, they predicted outcomes more effectively. CONCLUSIONS: This study showed that IL-2 treatment leads to a significant increase of immunological parameters, concomitantly with a reduction in vasculature, providing new insight into the cancer mechanisms mediated by IL-2. Moreover, these results suggest that tryptase-positive MCs and Foxp3 þ lymphocytes predict clinical outcomes in IL-2-treated patients, highlighting the critical role of the inflammatory response in mesothelioma cancer progression.

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Combination of peritumoral mast cells and T‐regulatory cells predicts prognosis of hepatocellular carcinoma

Cited by 68 publications

References 52 publications

Increased numbers of gastric-infiltrating mast cells and regulatory T cells are associated with tumor stage in gastric adenocarcinoma patients

Increased numbers of gastric-infiltrating mast cells and regulatory T cells are associated with tumor stage in gastric adenocarcinoma patients

Low Counts of γδ T Cells in Peritumoral Liver Tissue are Related to More Frequent Recurrence in Patients with Hepatocellular Carcinoma after Curative Resection

Treatment with interleukin-2 in malignant pleural mesothelioma: immunological and angiogenetic assessment and prognostic impact

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