Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome

Piche, Thierry; Saint–Paul, Marie–Christine; Dainese, Raffaella; Mariné-Barjoan, Eugènia; Iannelli, Antonio; Montoya, María Luisa Pedro-Botet; Peyron, Jean François; Czerucka, D; Chérikh, Faredj; Filippi, Jérôme; Tran, Albert; Hébuterne, Xavier

doi:10.1136/gut.2007.127068

Cited by 166 publications

(142 citation statements)

References 53 publications

(67 reference statements)

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“…Several groups have reported an increased density of T lymphocytes in the mucosa of IBS patients compared with healthy control patients ( Figure 2B). T-cell density was higher in the duodenum, 63 jejunum, 86 caecum, 69 colon, 38,58,77 rectosigmoid colon 58 and rectum. 22,58,64,79,80 However, a similar number of studies has found that IBS patients have a normal lymphocyte density in different intestinal tissue segments.…”

Section: In Patients With All Clinical Subtypes Of Ibs (D-ibs C-ibsmentioning

confidence: 99%

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

Matricon

Méleine

Gelot

et al. 2012

Aliment Pharmacol Ther

183

180

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This uncommissioned review article was subject to full peer-review. SUMMARY BackgroundIrritable bowel syndrome (IBS), one of the most common gastrointestinal disorders, markedly impairing patients' quality of life. Drug development for IBS treatment has been hampered by the lack of understanding of IBS aetiology. In recent years, numerous data have emerged that suggest the involvement of immune activation in IBS, at least in a subset of patients. AimTo determine whether immune activation and intestinal permeabilisation are more frequently observed in IBS patients compared with healthy controls. MethodsThe scientific bibliography was searched using the following keywords: irritable bowel syndrome, inflammation, immune activation, permeabilisation, intestine, assay, histology and human. The retrieved studies, including blood, faecal and histological studies, were analysed to provide a comprehensive and structured overview of the available data including the type of assay, type of inflammatory marker investigated or intestinal segment studied. ResultsImmune activation was more frequently observed in IBS patients than in healthy controls. An increase in the number of mast cells and lymphocytes, an alteration in cytokine levels and intestinal permeabilisation were reported in IBS patients. No consistent changes in the numbers of B cells or enterochromaffin cells or in mucosal serotonin production were demonstrated. ConclusionsThe changes observed were modest and often heterogeneous among the studied population. Only appropriate interventions improving irritable bowel syndrome symptoms could highlight and confirm the role of immune activation in this pathophysiology.

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Section: In Patients With All Clinical Subtypes Of Ibs (D-ibs C-ibsmentioning

confidence: 99%

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

Matricon

Méleine

Gelot

et al. 2012

Aliment Pharmacol Ther

183

180

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“…However, reports of variation in the absolute number of mast cells in the intestine are confl icting, as a similar number of studies indicate mast cell numbers are increased or unchanged in IBS patients ( Table 2 ) ( 44,48 -67 ). In those studies that observed increased mast cell numbers, correlations with symptoms are also mixed ( Table 1 ) ( 37,41,50,52,53,55,59,63 ). Despite this contention, the absolute number of mast cells may not be the defi ning characteristic of their involvement in IBS.…”

Section: Mast Cellsmentioning

confidence: 99%

Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?

Hughes

Zola

et al. 2013

American Journal of Gastroenterology

129

117

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Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal (GI) tract characterized by pain or discomfort from the lower abdominal region, which is associated with altered bowel habit. Despite its prevalence, there is currently a lack of effective treatment options for patients. IBS has long been considered as a neurological condition resulting from alterations in the brain gut axis, but immunological alterations are increasingly reported in IBS patients, consistent with the hypothesis that there is a chronic, but low-grade, immune activation. Mediators released by immune cells act to either dampen or amplify the activity of GI nerves. Release of a number of these mediators correlates with symptoms of IBS, highlighting the importance of interactions between the immune and the nervous systems. Investigation of the role of microbiota in these interactions is in its early stages, but may provide many answers regarding the mechanisms underlying activation of the immune system in IBS. Identifying what the key changes in the GI immune system are in IBS and how these changes modulate viscerosensory nervous function is essential for the development of novel therapies for the underlying disorder.

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“…12,14,25,29,30,33 Conversely, there appears to be no significant differences in tissue eosinophil counts of patients with IBS. 12,14,31,34 However, histopathological studies in pediatric patients with AP-FGID are relatively scarce, moreover, the results of some studies are discrepant from those of studies on adults. Friesen et al found that duodenal eosinophil density and degranulation was increased in children with FD.…”

Section: Introductionmentioning

confidence: 83%

“…13,[16][17][18][19][20][21] On the other hand, several studies also show increased infiltration and degranulation of gastric and duodenal mast cells in adult FD patients. 16,[22][23][24] In adult patients with IBS, most studies demonstrate increased infiltration of mast cells in all parts of the duodenum, 14 jejunum, 25 ileum, 26 and colon, 12,[27][28][29][30][31] with the exception of a few studies. 32,33 Previous studies also show an increase in T lymphocyte infiltrates.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Gastric and Duodenal Eosinophils in Children with Abdominal Pain Related Functional Gastrointestinal Disorders According to Rome III Criteria

Lee

Yang

Lee

2016

J Neurogastroenterol Motil

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Background/AimsAbdominal pain-related functional gastrointestinal disorder (AP-FGID) is common in children and adults. However, the mechanism of AP-FGID is not clearly known. Recently, micro-inflammation, especially eosinophilia in the gastrointestinal tract, was suggested in the pathophysiology of AP-FGID in adults. The aim of this study was to evaluate the association of gastric and duodenal eosinophilia with pediatric AP-FGID. MethodsIn total, 105 pediatric patients with AP-FGID were recruited and classified into 4 subgroups based on the Rome III criteria. Eosinophil counts in the gastric and duodenal tissues of children with AP-FGID were compared to those from normal pathology references or those of children with Helicobacter pylori infection. Tissue eosinophil counts were also compared among the 4 subtypes of AP-FGID. ResultsEosinophil counts in the gastric antrum and body were significantly higher in children with AP-FGID than normal reference values. Duodenal eosinophil counts were higher in children with AP-FGID, but not significantly when compared with normal reference values. There were no significant differences in eosinophil counts of the stomach or duodenum among the 4 subtypes of AP-FGID. Eosinophils counts in the gastric antrum and body were significantly higher in children with H. pylori infection than in those with AP-FGID. Duodenal eosinophilia was prominent in cases of H. pylori infection, but not statistically significant when compared with AP-FGID. ConclusionsOur study revealed that gastric eosinophilia is associated with AP-FGID in children, regardless of the subtype of functional abdominal pain. This suggests some contribution of gastrointestinal eosinophils in the development of pediatric AP-FGID.

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Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome

Cited by 166 publications

References 53 publications

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?

Analysis of Gastric and Duodenal Eosinophils in Children with Abdominal Pain Related Functional Gastrointestinal Disorders According to Rome III Criteria

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