Mast cells: A double-edged sword in cancer

Derakhshani, Afshin; Vahidian, Fatemeh; Ali‐Hasanzadeh, Mohammad; Mokhtarzadeh, Ahad; Nezhad, Parisa Lotfi; Baradaran, Behzad

doi:10.1016/j.imlet.2019.03.011

Cited by 71 publications

(69 citation statements)

References 132 publications

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“…Mast cells (MCs), a type of innate immune cells, are a potent proangiogenic factor in solid tumors, in which mast cell accumulation correlated with increased neovascularization, mast cell VEGF expression, tumor aggressiveness, and poor prognosis [42]. The present studies have revealed that mast cells have a pro-tumor or anti-tumor role depending on the type of cancer, the degree of tumor progression, and the location of these immune cells in the tumor site [43]. The natural killer (NK) cells were discovered for their ability to rapidly recognize and efficiently kill tumor cells [44], and to release a number of cytokines that regulate both innate and adaptive immune responses [45].…”

Section: Discussionmentioning

confidence: 76%

Profiles of immune cell infiltration in head and neck squamous carcinoma

Liang

Wang

2020

Bioscience Reports

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Tumor immune infiltration cells (TIICs) are highly heterogeneous, not only in different cancer subtypes but also within different cancer regions. We conducted the Cell-type Identification using Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) method. We assessed the relative proportions of 22 TIICs in HNSC using publicly available TCGA transcriptional datasets, analyzed the proportions of TIICs between HNSC tissues and normal tissues, along with accompanying clinicopathological data, and the impact of TIICs on clinical outcome. After the filter criteria, a total of 395 patients were included in the analysis. We found significant differences in naïve B cells, monocytes, resting mast cells, activated mast cells, CD8+ T cells, and M0 macrophages between HNSC tissues and adjacent non-cancer tissues. We also found that some TIIC subgroups were significantly associated with clinical parameters. Moreover, the patients with low Tregs fraction had worse OS and DFS than those with high Tregs fraction. However, low M0 macrophages fraction was associated with better OS and DFS in HNSC patients. Moreover, Tregs and M0 macrophages are likely to be important determinants of prognosis, which may serve as a potential immunotherapy target for HNSC. Then, we screened the immune-related differentially expressed genes (DEGs), performed the GO and KEGG enrichment analysis, constructed the protein–protein interaction network, and screened the prognosis-related hub genes in HNSC. However, further clinical investigation and basic experiments are needed to validate our results, and uncover the molecular mechanisms interlinking TIICs in HNSC and their roles in prognosis and therapy.

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Section: Discussionmentioning

confidence: 76%

Profiles of immune cell infiltration in head and neck squamous carcinoma

Liang

Wang

2020

Bioscience Reports

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“…However, in recent decades, more studies have found that mast cells also participate in innate and adaptive immune-related diseases, including cancer. [57][58][59] As a hormone-dependent tumour, CAFs in prostate tumours have a higher oestrogen receptor/androgen receptor (ER/AR) ratio compared with NFs. Ellem et al found that oestrogen-induced CAF expression recruited mast cells to the TME by secreting CXCL12 in prostate cancer.…”

Section: Interaction Between Cancer-associated Fibroblasts and Mastmentioning

confidence: 99%

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

Liu

Chen

et al. 2019

J Cellular Molecular Medi

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Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression.

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“…Based on hematopoietic stem cell-engineer, invariant NKT cell, a potent immune cell for targeting cancer, changed its disadvantage of low level in cancer patients and developed an original therapy proved with long-term effect and no toxicity in vivo [39] . Mast cells can both anti-tumor through tumor in ltration can directly affect the proliferation and invasion of tumor cells and promote tumor through the establishment of the tumor microenvironment and regulating tumor cell immune response and whether anti-tumor or promote tumor depends on cancer types, tumor progression and the location of immune cells in tumor [40,41] . Particularly, it was suggested that abnormal activation of mast cells led to lung immune dysfunction in smokers, which also contributes to tumor development and progression [42] .…”

Section: Discussionmentioning

confidence: 99%

COL1A1, COL1A2, COL3A1 and DCN are Potential Biomarkers to Predict Progression from Smokers to Suffering from Lung Adenocarcinoma

Chen

Wang

et al. 2020

Preprint

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Background: To explore novel related genes and potential biomarkers that predict progression from smokers to lung adenocarcinoma (LA). Methods: Three datasets from GEO (Gene Expression Omnibus) database were used to identify differentially expressed genes (DEGs) between LA tissue (LAT) and normal tumor adjacent tissue (TAT). The overlap of DEGs could be found and enriched in gene oncology (GO) and pathways to discover the potential biological mechanisms. Protein-protein interaction (PPI) network was applied to find the relationship among proteins. Survival analysis contributed to the definiteness of key genes. The expression of key genes in LA patients who smoke was verified. Furthermore, genetic alterations, co-expression and pathways of key genes were explored. To obtain more information, key genes were further analyzed in immune infiltration, drug target and the distribution of single cell in LA. Results: 245 DEGs were revealed in 3 datasets from GEO. In Kaplan Meier plotter, we found that high expression of COL1A1, COL1A2 and COL3A1 was associated with poorer survival while low expression of DCN was contributed to poorer survival in LAs who smoke. Thus, three up-regulated genes (COL1A1, COL1A2, COL3A1) and one down-regulated gene (DCN) were defined as key genes. Their genetic alterations were more common in female LA smokers and co-expression genes/proteins of them mainly functioned at extracellular matrix. Furthermore, COL1A1, COL1A2, COL3A1 genes had a common targeted drug called Collagenase clostridium histolyticum (DB00048) and DCN gene had a targeted drug called Tromethamine (DB03754). In the Single Cell Expression Atlas of EMBL-EBL, COL3A1 gene was specifically highly expressed in female LA patients with brain metastasis. Conclusions: COL1A1, COL1A2, COL3A1 and DCN could be regarded as novel potential biomarkers that predict progression from smokers to lung adenocarcinoma.

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Mast cells: A double-edged sword in cancer

Cited by 71 publications

References 132 publications

Profiles of immune cell infiltration in head and neck squamous carcinoma

Profiles of immune cell infiltration in head and neck squamous carcinoma

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

COL1A1, COL1A2, COL3A1 and DCN are Potential Biomarkers to Predict Progression from Smokers to Suffering from Lung Adenocarcinoma

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