“…A plethora of factors present in TME such as SCF, 429 VEGFs 238,252,219 , hypoxia, 455 adenosine, 456 PGE 2 238 can influence mast cell recruitment and activation. Moreover, several chemokines (CXCL1, CXCL10, and CXCL12), 252,457 cytokines (IL-33, IFNγ) 88,89,458 and immune complexes 459 can activate TAMCs in TME.…”