Mast cell mediated inflammatory response in chickens after infection with very virulent infectious bursal disease virus

Bacterial toxin-inducible gene expression of cathelicidin-B1 in the chicken bursal lymphoma-derived cell line DT40: Functional characterization of cathelicidin-B1

“…Mast cells play a critical role in immune response and inflammation [10,25] and reside in tissues throughout the body, particularly in tissues associated with structures such as blood vessels and nerves, and in tissues that interface with the external environment. Although BF can be regarded as one of such interface, few mast cells were observed in the BF of normal adult chickens [42,47]. However, the number and activity of mast cells in the BF were markedly increased after infection with very virulent infectious bursal disease virus (vvIBDV) [42].…”

“…Although BF can be regarded as one of such interface, few mast cells were observed in the BF of normal adult chickens [42,47]. However, the number and activity of mast cells in the BF were markedly increased after infection with very virulent infectious bursal disease virus (vvIBDV) [42]. In this study, we demonstrated the ability of chCATH-B1 to induce mast cell migration using mastocytoma cells, suggesting that chCATH-B1 may attract mast cells into the chicken BF at the time of infection by pathogenic organisms.…”

Acute hypersensitive-like injury in specific-pathogen-free chickens after infection with very virulent infectious bursal disease virus

“…Other researchers have emphasized the importance of T-lymphocytes and macrophages in the induction of tissue lesions (Kim et al, 2000;Khatri et al, 2005). Recently, our preliminary results disclosed the key role of mast cells and their mediators in affecting bursal injury after vvIBDV infection (Wang et al, 2008(Wang et al, , 2009a. Collectively, acute systemic inflammation and high mortality occurred within 100 h after vvIBDV infection.…”

Interaction of infectious bursal disease virus with the immune system of poultry

“…MCs recognise the viruses or dsRNA through TLR3 and produce a number of the cytokines and chemokines that leads to increase in the recruitment of the effector cells in that specific area (Abraham and St John, 2010;Moon et al, 2010). Severe histological lesions, increased MCs (at 1, 2, 3 rd DPI) and enhanced tryptase activity were observed in the thymus, spleen, glandular stomach, liver, kidney and especially in BF from infection with vvIBDV in chickens (Wang et al, 2008). Contrary to this finding, a decrease in the population of MCs were observed in the duodenum, jejunum and ileum (Figure 3) at second and third DPI with vvIBDV in specific pathogen free chickens (Wang et al, 2009b).…”

“…Bird age and genetic background differentially modulate the activity of T cell in IBDV infections Haase, 2005, Tippenhauer et al, 2013). Recruitment of CD4 and CD8 T-lymphocytes enhanced damage in the BF by releasing cytokines and causing a cytotoxic effect (Wang et al, 2008) that leads to prolonged immune suppression after IBD.…”