Mast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection

McLachlan, James B.; Hart, Justin P.; Pizzo, Salvatore V.; Shelburne, Christopher P.; Staats, Herman F.; Gunn, Michael D.; Abraham, Soman N.

doi:10.1038/ni1005

Cited by 285 publications

(249 citation statements)

References 40 publications

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“…In addition to local actions in the skin previous Wndings in mice show that as a result of dinitroXuorobenzene-induced contact hypersensitivity mast cells are activated and they migrate to draining lymph nodes wherein they can mediate T cell recruitment [198]. Further support for mast cellinduced lymph node activation and hypertrophy is provided by the study showing that activation of mast cells in mouse footpad by injection of Escherichia coli bacteria or compound 48/80 results in rapid draining of mast cell-derived preformed TNF to lymph nodes wherein it induces hypertrophy and recruitment of circulating T cells [115]. Further, Jawdat et al [81] have demonstrated that the mast celldependent lymph node activation in mice can be mast cell TNF-dependent in an allergic response or TNF-independent in a response to bacterial peptidoglycan injection.…”

Section: Mast Cells In Relation To Cells Of the Immune System In Psormentioning

confidence: 74%

Is there a role for mast cells in psoriasis?

et al. 2008

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Mast cells have traditionally been considered as eVector cells in allergy but during the last decade it has been realized that mast cells are essentially involved in the mechanisms of innate and acquired immunity. Upon activation by anaphylactic, piecemeal degranulation or degranulation-independent mechanisms mast cells can secrete rapidly or slowly a number of soluble mediators, such as serine proteinases, histamine, lipid-derived mediators, cytokines, chemokines and growth factors. Mast cells can express cell surface co-stimulatory receptors and ligands, and they can express MHC class II molecules and thereby present antigens. These soluble factors and cell surface molecules can interact with other cells, such as endothelial cells, keratinocytes, sensory nerves, neutrophils, T cell subsets and antigen presenting cells which are essential eVectors in the development of skin inXammation. Besides promoting inXammation, mast cells may attempt in some circumstances to suppress the inXammation and epidermal growth but the regulation between suppressive and proinXammatory mechanisms is unclear. Psoriasis is characterized by epidermal hyperplasia and chronic inXammation where tryptase-and chymase-positive MC TC mast cells are activated early in the developing lesion and later the cells increase in number in the upper dermis with concomitant expression of cytokines and TNF superfamily ligands as well as increased contacts with neuropeptide-containing sensory nerves. Due to the intimate involvement of mast cells in immunity and chronic inXammation the role of mast cells in psoriasis is discussed in this review.

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Section: Mast Cells In Relation To Cells Of the Immune System In Psormentioning

confidence: 74%

Is there a role for mast cells in psoriasis?

et al. 2008

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“…In many of these studies, the end points assessed included the recruitment of particular immune cells, such as granulocytes 28,32,33,[57][58][59][60][61]63,64,[67][68][69][70] , DCs 62,64,65,71 or various subpopulations of lymphocytes 64,67,70,72 . Many of these studies also demonstrated that the lack of mast cells 54,[57][58][59][60][61][62][63][64]67,69,70 or a specific mast-cell product 28,32,33,54,60,63,67,68,70 also reduced the pathology associated with the immune response or impaired its effectiveness in promoting host resistance to infection.…”

Section: Positive Immunomodulatory Functions In Vivomentioning

confidence: 99%

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

2008

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“…A study by Alard et al (19) suggested that mast cell-derived TNF might inhibit contact sensitization through effects on dendritic cells in mice. A recent report has also demonstrated that mast cell-derived TNF is primarily responsible for LN swelling following bacterial or compound 48/80-induced mast cell activation (20), while histamine did not contribute significantly to this response. Dendritic cells have, however, been shown to express H1, H2, and H3 receptors and to undergo significant maturational changes as a result of histamine treatment (11,(21)(22)(23).…”

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confidence: 99%

IgE-Mediated Mast Cell Activation Induces Langerhans Cell Migration In Vivo

Jawdat

Albert

Rowden

et al. 2004

The Journal of Immunology

123

118

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Langerhans cells and mast cells are both resident in large numbers in the skin and act as sentinel cells in host defense. The ability of mast cells to induce Langerhans cell migration from the skin to the draining lymph node in vivo was examined. Genetically mast cell-deficient (W/Wv) mice and control mice were sensitized with IgE Ab in the ear pinna. Seven to 14 days later, mice were challenged with Ag i.v. After a further 18–24 h, epidermal sheets and draining auricular lymph nodes were examined using Langerin/CD207 immunostaining. In mast cell-containing mice, a significant decrease in the number of Langerhans cells was observed at epidermal sites of mast cell activation. A significant increase in total cellularity and accumulation of Langerin-positive dendritic cells was observed in the auricular lymph nodes, draining the sites of IgE-mediated mast cell activation. These changes were not observed in W/Wv mice, but were restored by local mast cell reconstitution. Treatment of mast cell-containing mice with the H2 receptor antagonist cimetidine significantly inhibited the observed IgE/Ag-induced changes in Langerhans cell location. In contrast, Langerhans cell migration in response to LPS challenge was not mast cell dependent. These data directly demonstrate the ability of mast cells to induce dendritic cell migration to lymph nodes following IgE-mediated activation in vivo by a histamine-dependent mechanism.

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Mast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection

Cited by 285 publications

References 40 publications

Is there a role for mast cells in psoriasis?

Is there a role for mast cells in psoriasis?

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

IgE-Mediated Mast Cell Activation Induces Langerhans Cell Migration In Vivo

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