Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non‐obese mice

Ishijima, Yasushi; Ohmori, Shingo; Ohneda, Kinuko

doi:10.1016/j.fob.2013.11.004

Cited by 17 publications

(19 citation statements)

References 27 publications

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“…Mast cells (MCs) play a key role in adipogenesis by facilitating the transition of pre-adipocyte to adipocyte. 151 MC numbers are higher in the AT of obese subjects compared with lean individuals and their numbers are positively correlated with macrophage accumulation, endothelial cell inflammation, tissue fibrosis and IR. [152][153][154] During the progression of obesity, MCs are recruited into the AT and secrete a specific tryptase called mast cell protease 6 (MCP-6), which promotes the growth of collagen V-producing fibroblasts, facilitates AT fibrosis and causes IR.…”

Section: Mast Cellsmentioning

confidence: 90%

“…Mast cells (MCs) play a key role in adipogenesis by facilitating the transition of pre‐adipocyte to adipocyte . MC numbers are higher in the AT of obese subjects compared with lean individuals and their numbers are positively correlated with macrophage accumulation, endothelial cell inflammation, tissue fibrosis and IR .…”

Section: White Adipose Tissue (Wat) In Health and Obesitymentioning

confidence: 99%

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An update on immune dysregulation in obesity‐related insulin resistance

2019

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Obesity is associated with chronic low‐grade inflammation of the adipose tissue (AT) that might develop into systemic inflammation, insulin resistance (IR) and an increased risk of type 2 diabetes mellitus (T2DM) in severe obese rodents and humans. In the lean state, small normal adipocytes and AT macrophages interact with each other to maintain metabolic homeostasis but during obesity, enlarged adipocytes secrete inflammatory mediators and express immune receptors to recruit immune cells and aggravate the inflammation. The better understanding of the obesity‐related inflammatory milieu and the sequential events leading to IR could be helpful in designing new preventive and therapeutic strategies. The present review will discuss the cellular and molecular abnormalities participating in the pathogenesis of obesity in obese individuals as well as high‐fat diet (HFD)‐fed mice, a mouse model of obesity.

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Section: Mast Cellsmentioning

confidence: 90%

Section: White Adipose Tissue (Wat) In Health and Obesitymentioning

confidence: 99%

An update on immune dysregulation in obesity‐related insulin resistance

2019

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“… showed that the one of PGs metabolite generated by mast cells, 15‐deoxy‐delta PGJ2, induces adipocyte differentiation and possibly contributes to obesity development. On the other hand, the mRNA expression levels of preadipocyte marker genes, such as preadipocyte factor‐1, adipocyte enhancer binding protein 1 and GATA binding protein 2, increase in the WAT of Kit W‐sh/W‐sh mice under both obese and non‐obese conditions . It has been suggested a synergistic relationship between adipose tissue cells and mast cells because of the presence of a significant mast cell precursor and progenitor population in WAT.…”

Section: Adipose Tissue As a Reservoir Of Mast Cellsmentioning

confidence: 99%

Mast cells participate in chronic low‐grade inflammation within adipose tissue

et al. 2018

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Obesity is reckoned as one of the civilization diseases, posing a considerable global health issue. Evidence points towards a contribution of multitude immune cell populations in obesity pathomechanism and the development of chronic low-grade inflammation in the expanded adipose tissue. Notably, adipose tissue is a reservoir of mast cells which number in individuals with obesity particularly increased. Some of them tend to degranulation what generate secretion of strong pro-inflammatory and regulatory mediators, as well as cytokines/chemokines. Several lines of evidence suggest that mast cells are strictly associated with pro-inflammatory status in adipose tissue by their indirect impact on immune cell attraction and activation. Furthermore, mast cells affect adipose tissue remodelling and fibrosis by adipocyte differentiation, fibroblast proliferation and enhancing extracellular matrix proteins expression. This review will summarize current knowledge on mast cell features and their role in the development of chronic low-grade inflammation within adipose tissue.

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“…However, although increases in adipose mast cell density have been reported in visceral adipose tissue of obese mice (10) and abdominal subcutaneous adipose of obese patients (228), whether obesity influences mast cell density in breast subcutaneous or periprostatic adipose tissue has not been reported. Ishijima et al demonstrated that mast cells influence preadipocyte-adipocyte transition under both physiological and pathological conditions (182), suggesting a possible role for mast cells in adipose expansion. Furthermore, adipose tissue hematopoietic progenitor cells contain a population committed to the mast cell lineage, allowing white adipose tissue to act as a reservoir for mast cells that traffic to other tissues such as skin and, potentially, developing tumors (308).…”

Section: Adipose Tissue Immune Populations In Cancer Development and mentioning

confidence: 99%

Contribution of Adipose Tissue to Development of Cancer

Cozzo

Fuller

Makowski

2017

Comprehensive Physiology

149

130

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Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell-intrinsic anomalies. Due to the ubiquitous nature of adipose tissue, many types of solid tumors grow in proximate or direct contact with adipocytes and adipose-associated stromal and vascular components, such as fibroblasts and other connective tissue cells, stem and progenitor cells, endothelial cells, innate and adaptive immune cells, and extracellular signaling and matrix components. Excess adiposity in obesity both increases risk of cancer development and negatively influences prognosis in several cancer types, in part due to interaction with adipose tissue cell populations. Herein, we review the cellular and noncellular constituents of the adipose “organ,” and discuss the mechanisms by which these varied microenvironmental components contribute to tumor development, with special emphasis on obesity. Due to the prevalence of breast and prostate cancers in the United States, their close anatomical proximity to adipose tissue depots, and their complex epidemiologic associations with obesity, we particularly highlight research addressing the contribution of adipose tissue to the initiation and progression of these cancer types. Obesity dramatically modifies the adipose tissue microenvironment in numerous ways, including induction of fibrosis and angiogenesis, increased stem cell abundance, and expansion of proinflammatory immune cells. As many of these changes also resemble shifts observed within the tumor microenvironment, proximity to adipose tissue may present a hospitable environment to developing tumors, providing a critical link between adiposity and tumorigenesis.

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Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non‐obese mice

Cited by 17 publications

References 27 publications

An update on immune dysregulation in obesity‐related insulin resistance

An update on immune dysregulation in obesity‐related insulin resistance

Mast cells participate in chronic low‐grade inflammation within adipose tissue

Contribution of Adipose Tissue to Development of Cancer

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