Mast cell and plasma cell collision tumor in the spleen of a dog

Pallatto, Valarie A.; Bechtold, Molly A.

doi:10.1111/vcp.12596

Cited by 6 publications

(11 citation statements)

References 16 publications

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“…[6][7][8][9][10][11][12] Interestingly, in cats, concurrent gastrointestinal lymphoma and visceral MCT have been reported, and most veterinarians have seen evidence of this in practice. 13 However, in dogs, more than one type of hematopoietic neoplasia present concurrently is relatively uncommon, [14][15][16][17][18] particularly for previous studies of HSTCL.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, in cats, concurrent gastrointestinal lymphoma and visceral MCT have been reported, and most veterinarians have seen evidence of this in practice 13 . However, in dogs, more than one type of hematopoietic neoplasia present concurrently is relatively uncommon, 14–18 particularly for previous studies of HSTCL. Therefore, one should consider a newly developed neoplasm in the same organ as a differential during the monitoring of long‐term HSTCL therapy, 6 even if the first tumor is HSTCL.…”

Section: Discussionmentioning

confidence: 99%

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Hepatosplenic lymphoma and visceral mast cell tumor in the liver of a dog with synchronous and multiple primary tumors

Akiyoshi

Hisasue

Asakawa

et al. 2022

Veterinary Clinical Pathol

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An 11‐year‐old spayed female American Cocker Spaniel was presented with a 4‐week history of anorexia and a 1‐week history of abdominal distension. Clinicopathologic and imaging abnormalities included intra‐abdominal hemorrhage, granular lymphocytes (GLs) in abdominal fluid smears, a splenic mass, and hepatomegaly with diffuse multiple hypoechogenic nodules. Based on the cytologic, histologic, and immunohistochemical evaluation of the spleen and liver, the diagnosis was hepatosplenic T‐cell lymphoma (HSTCL) of GLs. Postoperatively, the dog was maintained in good condition with chemotherapy (ACNU [nimustine], L‐asparaginase, and prednisolone). However, on day 85, ultrasound‐guided fine‐needle aspiration of the liver revealed a proliferation in neoplastic mast cells not associated with the GLs. The dog was diagnosed with a visceral mast cell tumor (MCT) originating from the liver. The chemotherapy was switched to vinblastine and toceranib. The dog remained in good condition until day 141 but died due to the progression of MCT on day 158. Liver cytology on day 155 showed no GLs, although HSTCL is thought to be resistant to chemotherapy. After the definitive diagnosis of HSTCL, we monitored this patient's response to chemotherapy with blood tests, including complete blood counts, ultrasound imaging, and cytologic aspirates of liver. Although canine HSTCL has a poor prognosis, the possibility of a new neoplasm, including visceral MCT, should be considered. Periodic liver cytology might be worthwhile in dogs receiving chemotherapy for HSTCL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hepatosplenic lymphoma and visceral mast cell tumor in the liver of a dog with synchronous and multiple primary tumors

Akiyoshi

Hisasue

Asakawa

et al. 2022

Veterinary Clinical Pathol

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“…In one study performed over a 15‐year period, only 8% (10/118) of all MCTs represented visceral MCTs 6,8 . Moreover, within this group, primary splenic MCT is a rare presentation, with only two cases confirmed in the veterinary literature to the authors’ knowledge 2,7 . One dog was diagnosed with a plasma cell and mast cell collision tumour on splenic cytology but was lost to follow‐up 2 .…”

Section: Discussionmentioning

confidence: 99%

“…The clinical presentation is extremely variable ranging from benign to highly malignant tumours. Disseminated forms of the disease, also called mastocytosis, usually occur as a result of metastasis from a primary cutaneous tumour and much less commonly due to a visceral form of MCT 2–4 . Primary visceral MCTs, and specifically splenic mast cell neoplasia, are rare 2,5–7 in dogs and carry a guarded prognosis 4,6,8 .…”

Section: Introductionmentioning

confidence: 99%

Spontaneous haemoabdomen due to a ruptured primary splenic mast cell tumour in a dog

Alves‐Nores

Naranjo²,

Fernández

2022

Vet Record Case Reports

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A 14-year-old, female, spayed warren hound presented with an acute history of collapse, pale mucous membranes and abdominal distension. Abdominal ultrasound and abdominocentesis revealed a haemoabdomen secondary to a ruptured splenic mass. The dog underwent an emergency splenectomy and splenic histopathology, including toluidine blue staining, was consistent with a mast cell tumour. The dog was diagnosed with a primary splenic mast cell tumour based on the absence of a primary mast cell tumour in another location at the time of presentation or in a review of the dog's medical record. Following surgery, staging identified hepatic infiltration, and adjuvant chemotherapy with vinblastine and prednisolone was started. The dog was euthanased 97 days after surgery due to progressive disease and recurrence of the haemoabdomen. Visceral mast cell tumours should be considered as an uncommon differential diagnosis in dogs presenting with haemoabdomen due to a ruptured splenic mass.

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“…Microscopically, a mixed or composite tumour will have admixing of the cell types, whereas in a collision tumour, both cell types are present but separate. 4 Collision tumours are rare but have been reported in humans, [5][6][7][8][9] dogs, 1 4 10 11 a rabbit, 12 a hamster 13 and a goat. 14 In the human literature, collision tumours in both primary sites 5 9 15 and metastatic lymph nodes 6 8 16 have been reported.…”

Section: Discussionmentioning

confidence: 99%

Collision tumour of two nodal metastases (adenocarcinoma and mast cell tumour) in a dog

Gibson¹,

Beck

Gonzalez-Gasch³

et al. 2020

Vet Record Case Reports

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An 11-year-old female neutered Labrador retriever was referred for a large vulvar mast cell tumour that extended into the vagina. Abdominal ultrasound revealed an enlarged right medial iliac lymph node, and cytology of the node was consistent with an endocrine/neuroendocrine tumour. An approximately 1.5-cm right anal sac mass was palpated. Medial iliac lymphadenectomy via ventral celiotomy, right anal sacculectomy and marginal vulvar mass resection were performed. Histopathology was consistent with right anal sac adenocarcinoma, vulvar mast cell tumour, and the right medial iliac lymph node showed a metastatic collision of both the adenocarcinoma and mast cell tumour cell populations. Adjunctive chemotherapy and radiotherapy were recommended to address the risk of local recurrence and further metastasis but were declined by the owner. The dog remains alive and asymptomatic with no visible evidence of recurrence 14 months after initial presentation.

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Mast cell and plasma cell collision tumor in the spleen of a dog

Cited by 6 publications

References 16 publications

Hepatosplenic lymphoma and visceral mast cell tumor in the liver of a dog with synchronous and multiple primary tumors

Hepatosplenic lymphoma and visceral mast cell tumor in the liver of a dog with synchronous and multiple primary tumors

Spontaneous haemoabdomen due to a ruptured primary splenic mast cell tumour in a dog

Collision tumour of two nodal metastases (adenocarcinoma and mast cell tumour) in a dog

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