In this work, we propose a powerful probe of neutrino effects on the large-scale structure (LSS) of the Universe, i.e., Minkowski functionals (MFs). The morphology of LSS can be fully described by four MFs. This tool, with strong statistical power, is robust to various systematics and can comprehensively probe all orders of N-point statistics. By using a pair of high-resolution N-body simulations, for the first time, we comprehensively studied the subtle neutrino effects on the morphology of LSS. For an ideal LSS survey of volume ∼ 1.73 Gpc 3 /h 3 , neutrino signals are mainly detected from void regions with a significant level up to ∼ 10σ and ∼ 300σ for CDM and total matter density fields, respectively. This demonstrates its enormous potential for much improving the neutrino mass constraint in the data analysis of up-coming ambitious LSS surveys.