Massive Splenomegaly Indicating Sarcoidosis

Bachmeyer, Claude; Fayand, Antoine; Georgin‐Lavialle, Sophie; Fedida, Benjamin; Naccache, Jean‐Marc; Lionnet, François

doi:10.1016/j.amjmed.2016.11.033

Cited by 5 publications

(3 citation statements)

References 4 publications

(10 reference statements)

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“…To the best of our knowledge, there are only 11 cases of isolated splenic sarcoidosis in the literature (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Table I shows these 11 cases and the present case.…”

Section: Discussionmentioning

confidence: 99%

“…The most frequently affected organ is the lung, which accounts for 90% of all cases of sarcoidosis, followed by eyes, heart and lymphatic system (1). Splenic sarcoidosis is rare and has been reported sporadically (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Therefore, how to treat, diagnose, and manage isolated splenic sarcoidosis is not established.…”

Section: Introductionmentioning

confidence: 99%

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A rare case of isolated splenic sarcoidosis: A case report and literature review

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A rare case of isolated splenic sarcoidosis: A case report and literature review

et al. 2020

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“…92 Splenic sarcoidosis may cause hypersplenism with anemia, leukopenia, thrombocytopenia, or any combination including pancytopenia. [114][115][116][117][118][119] For these reasons, a complete blood count should be routinely performed in a sarcoidosis patient. 6 It is important to note that sarcoidosis may also cause a reduction in blood cell lines because of bone marrow involvement, a sarcoidosis-induced autoimmune reaction (via autoantibody production), 118,119 or from toxicities of several sarcoidosis medications.…”

Section: Other Organ Screeningmentioning

confidence: 99%

Screening Sarcoidosis Patients for Occult Disease

Judson

2020

Semin Respir Crit Care Med

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As sarcoidosis may involve any organ, sarcoidosis patients should be evaluated for occult disease. Screening for some organ involvement may not be warranted if it is unlikely to cause symptoms, organ dysfunction, or affect clinical outcome. Even organ involvement that affects clinical outcome does not necessarily require screening if early detection fails to change the patient's quality of life or prognosis. On the other hand, early detection of some forms of sarcoidosis may improve outcomes and survival. This manuscript describes the approach to screening sarcoidosis patients for previously undetected disease. Screening for sarcoidosis should commence with a meticulous medical history and physical examination. Many sarcoidosis patients present with physical signs or symptoms of sarcoidosis that have not been recognized as manifestations of the disease. Detection of sarcoidosis in these instances depends on the clinician's familiarity with the varied clinical presentations of sarcoidosis. In addition, sarcoidosis patients may present with symptoms or signs that are not related to specific organ involvement that have been described as parasarcoidosis syndromes. It is conjectured that parasarcoidosis syndromes result from systemic release of inflammatory mediators from the sarcoidosis granuloma. Certain forms of sarcoidosis may cause permanent and serious problems that can be prevented if they are detected early in the course of their disease. These include (1) ocular involvement that may lead to permanent vision impairment; (2) vitamin D dysregulation that may lead to hypercalcemia, nephrolithiasis, and permanent kidney injury; and (3) cardiac sarcoidosis that may lead to a cardiomyopathy, ventricular arrhythmias, heart block, and sudden death. Screening for these forms of organ involvement requires detailed screening approaches.

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Hepatic and splenic involvement in sarcoidosis

Jeny¹,

Hamzeh²

2022

Sarcoidosis

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Massive Splenomegaly Indicating Sarcoidosis

Cited by 5 publications

References 4 publications

A rare case of isolated splenic sarcoidosis: A case report and literature review

A rare case of isolated splenic sarcoidosis: A case report and literature review

Screening Sarcoidosis Patients for Occult Disease

Hepatic and splenic involvement in sarcoidosis

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