A rare case of isolated splenic sarcoidosis: A case report and literature review

Kobayashi, Kazuki; Einama, Takahiro; Fujinuma, Ibuki; Tsunenari, Takazumi; Miyata, Yuhei; Iwasaki, Tetsushi; Asakuma, Junichi; Soga, Shigeyoshi; Shinmoto, Hiroshi; Tsujimoto, Hironori; Hase, Kazuo; Ueno, Hideki; Kishi, Yoji

doi:10.3892/mco.2020.2184

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…We searched PubMed with the terms "isolated splenic sarcoidosis" and "primary splenic sarcoidosis" for articles published in English until December 31, 2021. We found 14 isolated splenic sarcoidosis cases and summarized their details in Table 3, including our own 2 cases (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Isolated splenic sarcoidosis was more common in women than in men, and abdominal pain and weight loss were frequently identified as subjective symptoms.…”

Section: Discussionmentioning

confidence: 99%

Two Cases with Isolated Splenic Sarcoidosis Diagnosed by an Ultrasound-guided Fine-needle Aspiration Biopsy

et al. 2023

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Asymptomatic splenic nodules were detected incidentally in two middle-aged women at an annual checkup. They showed no abnormalities on laboratory tests, but imaging studies revealed splenic nodules. No other localized lesions were found. Splenic nodules were hypoechoic on ultrasonography (US), hypovascular on contrast-enhanced computed tomography, and showed a low intensity on T2-weighted magnetic resonance imaging. We performed US-guided percutaneous aspiration biopsies using 21-gauge needles without complications, including bleeding. Pathological specimens showed noncaseating granulomas, so both patients were diagnosed with isolated splenic sarcoidosis. A US-guided fine-needle aspiration biopsy is a safe and useful method for diagnosing splenic nodules.

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Section: Discussionmentioning

confidence: 99%

Two Cases with Isolated Splenic Sarcoidosis Diagnosed by an Ultrasound-guided Fine-needle Aspiration Biopsy

et al. 2023

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Isolated splenic sarcoidosis: a rare cause of hypercalcaemia in a patient with type 1 diabetes

et al. 2021

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A 30-year-old man was admitted to Intensive Therapy Unit (ITU) with status epilepticus secondary to severe hypoglycaemia on a background of type 1 diabetes. CT of the brain showed generalised cerebral oedema. He was successfully stepped down to a medical ward after 2 weeks. He was noted to have persistently high calcium, which required multiple doses of pamidronate. Parathyroid hormone level was appropriately low. CT of the thorax, abdomen and pelvis showed mild hepatosplenomegaly with small pathological lymph nodes throughout the abdomen. Bone marrow biopsy was unremarkable. Lymph node biopsy was difficult to achieve, and therefore a positron emission tomography scan was arranged. This showed an enlarged and hypermetabolic spleen. Differential diagnoses at this point included lymphoma and sarcoidosis. He underwent diagnostic splenectomy, and the diagnosis of sarcoidosis was confirmed histologically. Calcium level remained normal 17 months after splenectomy.

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Laparoscopic splenectomy for isolated sarcoidosis of the spleen. Clinical case

Галлямов

Shalygin

Kikhlyarov

et al. 2023

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The clinical case presented in this article illustrates one of the rare manifestations of systemic sarcoidosis — an isolated sarcoidosis lesion of the spleen. In a 36-year-old patient, based on anamnestic information and preoperative instrumental examination, a nonspecific granulomatous lesion of the spleen was suspected. Surgical intervention was performed in the scope of laparoscopic splenectomy with subsequent morphological verification of the diagnosis. According to the pathohistological examination, the diagnosis of sarcoidosis of the spleen was established. The patient was discharged in a satisfactory condition on the 6th day.

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A rare case of isolated splenic sarcoidosis: A case report and literature review

Cited by 4 publications

References 11 publications

Two Cases with Isolated Splenic Sarcoidosis Diagnosed by an Ultrasound-guided Fine-needle Aspiration Biopsy

Two Cases with Isolated Splenic Sarcoidosis Diagnosed by an Ultrasound-guided Fine-needle Aspiration Biopsy

Isolated splenic sarcoidosis: a rare cause of hypercalcaemia in a patient with type 1 diabetes

Laparoscopic splenectomy for isolated sarcoidosis of the spleen. Clinical case

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