Massive proteinuria and acute renal failure in a patient with acute silicoproteinosis

Giles, R. D.; Sturgill, Benjamin C.; Suratt, Paul M.; Bolton, W. Kline

doi:10.1016/0002-9343(78)90063-3

Cited by 42 publications

(25 citation statements)

References 5 publications

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“…An expected outcome of this process vould be the redistribution of particles to other body sites (267). The appearance ofparticle-containing macrophage as well as free particles in various body organs lends support to this possibility (48,(268)(269)(270).…”

Section: Tracheobronchial Lymph Node Macrophagesmentioning

confidence: 91%

Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung.

Lehnert

1992

Environ Health Perspect

151

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Pulmonary macrophages consist of several subpopulations that can be defined by their anatomial locations as well as by other criteria. In addition to,the well-known alveolar macrophages that reside on the alveolar surface, pulmonary macrophages also occur in the conductingairways, in various pulmonar interstitial regions, and, in some mammalian species, in the lung's intravacular compartment. Other thoracic macrophages of relevance to puhnonary defense and some lung disem processesare the pleiural macrophages resident in the pleural space and macrophages present in regional lymph nodes that receive lymphatic drainge from the lung. Of the above subpopulations of pulmonar and thoracic macrophages, the alveolar macrophages have received the most experimental attention in the context ofthe pulmonary clearance and retenton of d particls. Accordingly, less infmationis currently alable rardig the roles other pulmonary and thoracic populations of a g may play inthe removalof partcles from the lower rsprtor tract and associatedtissue compartments. This report provides an overview ofthe various subpopulations of pulmonary and thoracic macrophages, as defined by their anaial locations. The known and postulated roles ofmacrophages in the pulmonary clearnce and retention of particles are reviewed, with particular emphasis on macrophage-associated processes involved in the pulmonary clearance of relatively insoluble particles.

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Section: Tracheobronchial Lymph Node Macrophagesmentioning

confidence: 91%

Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung.

Lehnert

1992

Environ Health Perspect

151

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“…Animal studies have demonstrated that silica ca n produce a dose-related nephropath y that is primarily tubular and is ass ociated with inter stitial inflamma tory rea cti on s and fibrosis ( I, 2) . Several ca ses of nephropathy in workers exposed to silica ha ve been reported (3)(4)(5)(6)(7)(8)(9). The nephropathy has usually consis ted of a focal or seg mental, rapidly progressi ve glomerulonephritis without sig nific ant immune-complex deposits and with variable degrees of tubular degeneration.…”

mentioning

confidence: 99%

Early indicators of renal dysfunction in silicotic workers.

Boujemaa¹,

Lauwerys²,

Bernard³

1994

Scand J Work Environ Health

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“…Anecdotal reports and uncontrolled studies of clinical and pathological case series suggest that severe pulmonary silicosis, especially acute silicosis, is associated with glomerulotubular disease. [1][2][3][4][5][6][7][8] We have also reported preliminary findings from a recent cross 907 sectional study of an increased urinary excretion of albumin, a-l-microglobulin (AMG), and [-Nacetyl-glucosaminidase (NAG) in granite workers with high exposure to silica compared with healthy unexposed subjects.9 Some of these alterations in renal function, particularly for albumin and NAG, were apparently greater and persistent in silicotic subjects who were assumed to have had greater exposure to dust and who had not been exposed to silica for many years. We have replicated the study in another larger group of granite workers, with the further aim of elucidating the exposure-effect relation between the urinary alterations on the one hand and the intensity and duration of exposure to silica on the other.…”

mentioning

confidence: 99%

Further evidence of human silica nephrotoxicity in occupationally exposed workers.

Lee²,

Phoon³

1993

Occupational and Environmental Medicine

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It has previously been shown that granite workers with heavy exposure to silica had glomerular and proximal tubular dysfunction evidenced by increased urinary excretions of albumin, a-l-microglobulin (AMG), and -Nacetyl-glucosaminidase (NAG). The investigation was replicated in another group of granite workers to further elucidate the exposure effect relation. The urinary excretion of albumin, a-l-microglobulin (AMG), /-2-microglobulin (BMG), and /-N-acetylglucosaminidase (NAG) was determined in two groups of granite workers with low and high exposure to silica. Low molecular weight proteinuria and enzymuria were significantly correlated with duration of exposure in the high but not the low exposure group. These increases were most pronounced in those with 10 or more years of heavy exposure, and in those with radiological evidence of pulmonary fibrosis, particularly those with rounded small opacities denoting classical silicosis. These results provide further evidence that prolonged and heavy exposure to silica is associated with nephrotoxic effects in granite workers. (British J7ournal ofIndustrial Medicine 1993;50:907-912).The evidence that silica is nephrotoxic in occupationally exposed persons is limited. Anecdotal reports and uncontrolled studies of clinical and pathological case series suggest that severe pulmonary silicosis, especially acute silicosis, is associated with glomerulotubular disease. [1][2][3][4][5][6][7][8] We have also reported preliminary findings from a recent cross 907 sectional study of an increased urinary excretion of albumin, a-l-microglobulin (AMG), and [-Nacetyl-glucosaminidase (NAG) in granite workers with high exposure to silica compared with healthy unexposed subjects.9 Some of these alterations in renal function, particularly for albumin and NAG, were apparently greater and persistent in silicotic subjects who were assumed to have had greater exposure to dust and who had not been exposed to silica for many years. We have replicated the study in another larger group of granite workers, with the further aim of elucidating the exposure-effect relation between the urinary alterations on the one hand and the intensity and duration of exposure to silica on the other. Materials and methodsThe study subjects were selected from among a total of 159 workers in three granite quarries (not covered in the previous study), who held jobs with differing intensities of exposure to dust. A high dust exposure group of workers included those who were employed regularly in rock drilling and rock crushing jobs for at least a year; whereas a low exposure group included the rest of the workers who were mostly employed in equipment and vehicle maintenance and servicing work in the workshops, as loader operators and dumper truck drivers, and other administrative workers (clerks, office assistants, storemen etc). The exclusion criteria were a known history of glomerulonephritis, urinary calculi, or other renal diseases or diabetes, hypertension, or regular recent ingestion of analgesics. A total ...

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Massive proteinuria and acute renal failure in a patient with acute silicoproteinosis

Cited by 42 publications

References 5 publications

Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung.

Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung.

Early indicators of renal dysfunction in silicotic workers.

Further evidence of human silica nephrotoxicity in occupationally exposed workers.

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