Early indicators of renal dysfunction in silicotic workers.

Boujemaa, W; Lauwerys, Robert; Bernard, Alfred

doi:10.5271/sjweh.1411

Cited by 22 publications

(15 citation statements)

References 12 publications

(15 reference statements)

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“…Our results support published evidence that silica is associated with PSV. Most previous studies indicate that the duration of silica exposure is less important than its intensity (e.g., ORs for sandblasting are much higher than for building trades) (32–34). We also found no increased risk with duration of exposure, but the questionnaire was not designed to assess levels of exposure.…”

Section: Discussionmentioning

confidence: 99%

Are environmental factors important in primary systemic vasculitis?: A case–control study

Lane¹,

Watts²,

Bentham³

et al. 2003

Arthritis & Rheumatism

188

137

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Objective. To investigate the association between primary systemic vasculitis (PSV) and environmental risk factors.Methods. Seventy-five PSV cases and 273 controls (220 nonvasculitis, 19 secondary vasculitis, and 34 asthma controls) were interviewed using a structured questionnaire. Factors investigated were social class, occupational and residential history, smoking, pets, allergies, vaccinations, medications, hepatitis, tuberculosis, and farm exposure in the year before symptom onset (index year). The Standard Occupational Classification 2000 and job-exposure matrices were used to assess occupational silica, solvent, and metal exposure. Stepwise multiple logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval Conclusion. A significant association between farming and PSV has been identified for the first time. Results also support previously reported associations with silica, solvents, and allergy.The primary systemic vasculitides (PSV) are a group of relatively rare diseases of unknown etiology (1). A number of potential environmental risk factors have been reported. Systemic vasculitis has been associated with exposure to particulate silica (e.g., quartz, granite, sandstone, and grain dust) (2-5). There has been conflicting evidence regarding a link between occupational exposure to hydrocarbons (e.g., paints, glues) and Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA), and the association with glomerulonephritis is stronger (6-8). A case-control study carried out at the National Institutes of Health (NIH) revealed an association with exposure to fumes or particulates and pesticides in patients with WG compared with healthy or rheumatic disease controls but not respiratory disease

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Section: Discussionmentioning

confidence: 99%

Are environmental factors important in primary systemic vasculitis?: A case–control study

Lane¹,

Watts²,

Bentham³

et al. 2003

Arthritis & Rheumatism

188

137

View full text Add to dashboard Cite

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“…5 Two mortality studies conducted among granite cutters exposed to silica 6 and gold miners in the United States 7 have indicated an increased risk of death for chronic renal diseases. Two case-control studies have also suggested an association between exposure to silica and end stage renal disease.…”

mentioning

confidence: 99%

End stage renal disease among ceramic workers exposed to silica.

et al. 1999

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Objectives-To evaluate whether ceramic workers exposed to silica experience an excess of end stage renal disease. Methods-On the basis of a health surveillance programme, a cohort of 2980 male ceramic workers has been enrolled during the period 1974-91 in Civitacastellana, Lazio, Italy. For each worker, employment history, smoking data, and x ray film readings were available. The vital status was ascertained for all cohort members. All 2820 people still alive and resident in the Lazio region as in June 1994 were searched for a match in the regional end stage renal diseases registry, which records (since June, 1994) all patients undergoing dialysis treatment in public and private facilities of the region. Expected numbers of prevalent cases from the cohort were computed by applying the rate of patients on dialysis treatment by the age distribution of the cohort. Results-A total of six cases was detected when 1.87 were expected (observed/ expected (O/E)=3.21; 95% confidence interval (95% CI) 1.17 to 6.98). The excess risk was present among non-smokers (O=2; O/E=4.34) and smokers (O=4; O/E=2.83), as well as among workers without silicosis (O=4; O/E=2.78) and workers with silicosis (O=2; O/E=4.54). The risk was higher among subjects with <20 years since first employment (O=4; O/E=4.65) than among those employed >20 years. Conclusion-These results provide further evidence that exposure to silica dust among ceramic workers is associated with nephrotoxic eVects. (Occup Environ Med 1999;56:559-561)

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“…Only one previous study incorporated information on intensity of silica exposure (11). This is particularly important because studies of associations of silica exposure in other autoimmune diseases (12,13) and general renal dysfunction (14,15) suggested that intensity of exposure may be more important than duration of exposure in terms of its influence on disease risk (8). In addition, individuals with other renal diseases were used as control subjects in two studies (5,6).…”

mentioning

confidence: 99%

Association of Silica Exposure with Anti–Neutrophil Cytoplasmic Autoantibody Small-Vessel Vasculitis

Hogan¹,

Cooper²,

Savitz³

et al. 2007

Clinical Journal of the American Society of Nephrology

110

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Anti-neutrophil cytoplasmic autoantibodies (ANCA) are associated with a category of small-vessel vasculitis (SVV) with frequent glomerulonephritis. The goal of this study was to evaluate the association of lifetime silica exposure with development of ANCA-SVV, with particular attention to exposure dosage, intensity, and time since last exposure. A southeastern United States, population-based, case-control study was conducted. Case patients had ANCA-SVV with pauci-immune crescentic glomerulonephritis. Population-based control subjects were frequency-matched to case patients by age, gender, and state. Jobs were assessed in a telephone interview. Silica exposure scores incorporated exposure duration, intensity, and probability for each job and then were categorized as none, low/medium, or high lifetime exposure. Logistic regression models were used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Silica exposure was found in 78 (60%) of 129 case patients and in 49 (45%) of 109 control subjects. There was no increased risk for disease from low/medium exposure relative to no exposure (OR 1.0; 95% CI 0.4 to 2.2) but increased risk with high exposure (OR 1.9; 95% CI 1.0 to 3.5; P ‫؍‬ 0.05). Crop harvesting was associated with elevated risk (OR 2.5; 95% CI 1.1 to 5.4; P ‫؍‬ 0.03). However, both agricultural and traditional occupational sources contributed to the cumulative silica exposure scores; therefore, the overall effect could not be attributed to agricultural exposures alone. There was no evidence of decreasing by duration of time since last exposure. High lifetime silica exposure was associated with ANCA-SVV. Exposure to silica from specific farming tasks related to harvesting may be of particular importance in the southeastern United States. Interval of time since last exposure did not influence development of ANCA-SVV.

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Early indicators of renal dysfunction in silicotic workers.

Cited by 22 publications

References 12 publications

Are environmental factors important in primary systemic vasculitis?: A case–control study

Are environmental factors important in primary systemic vasculitis?: A case–control study

End stage renal disease among ceramic workers exposed to silica.

Association of Silica Exposure with Anti–Neutrophil Cytoplasmic Autoantibody Small-Vessel Vasculitis

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