Massive obesity treated by intermittent fasting

Stewart, W. K.; Fleming, Leanne; Robertson, Peter C.

doi:10.1016/0002-9343(66)90209-9

Cited by 23 publications

(5 citation statements)

References 35 publications

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“…Body weight loss and length offast The amount of weight lost and the rate of loss were not strikingly different from that of an earlier patient (Stewart, Fleming & Robertson, 1966) who reduced his weight from 432 to 235 lb during 350 days of intermittent starvation.…”

Section: Discussioncontrasting

confidence: 51%

Features of a successful therapeutic fast of 382 days' duration

Stewart

Fleming

1973

Postgraduate Medical Journal

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Section: Discussioncontrasting

confidence: 51%

Features of a successful therapeutic fast of 382 days' duration

Stewart

Fleming

1973

Postgraduate Medical Journal

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“…1 Increasing numbers of obese individuals are undergoing bariatric surgery, but this remains a restricted minority treatment. 36 The mainstay of treatment for obesity therefore remains lifestyle intervention based around dietary changes 37-40 which generally form the first step in any weight loss programme.…”

Section: Intermittent Fasting and Obesitymentioning

confidence: 99%

Intermittent fasting: a dietary intervention for prevention of diabetes and cardiovascular disease?

Brown

Mosley

Aldred

2013

Diabetes & Vascular Disease

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“…These findings suggest important roles for leptin and IGF-1 signaling mechanisms in the effects of CR on growth. Studies performed approximately 40 years ago demonstrated that intermittent fasting periods of days to weeks could be effective in the correction and control of obesity in humans (34,121). In rodents, the effects of EODF on body weight differ among species and strains.…”

Section: Growth and Reproductionmentioning

confidence: 99%

ENERGY INTAKE, MEAL FREQUENCY, AND HEALTH: A Neurobiological Perspective

2005

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The size and frequency of meals are fundamental aspects of nutrition that can have profound effects on the health and longevity of laboratory animals. In humans, excessive energy intake is associated with increased incidence of cardiovascular disease, diabetes, and certain cancers and is a major cause of disability and death in industrialized countries. On the other hand, the influence of meal frequency on human health and longevity is unclear. Both caloric (energy) restriction (CR) and reduced meal frequency/intermittent fasting can suppress the development of various diseases and can increase life span in rodents by mechanisms involving reduced oxidative damage and increased stress resistance. Many of the beneficial effects of CR and fasting appear to be mediated by the nervous system. For example, intermittent fasting results in increased production of brain-derived neurotrophic factor (BDNF), which increases the resistance of neurons in the brain to dysfunction and degeneration in animal models of neurodegenerative disorders; BDNF signaling may also mediate beneficial effects of intermittent fasting on glucose regulation and cardiovascular function. A better understanding of the neurobiological mechanisms by which meal size and frequency affect human health may lead to novel approaches for disease prevention and treatment.

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Massive obesity treated by intermittent fasting

Cited by 23 publications

References 35 publications

Features of a successful therapeutic fast of 382 days' duration

Features of a successful therapeutic fast of 382 days' duration

Intermittent fasting: a dietary intervention for prevention of diabetes and cardiovascular disease?

ENERGY INTAKE, MEAL FREQUENCY, AND HEALTH: A Neurobiological Perspective

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