ENERGY INTAKE, MEAL FREQUENCY, AND HEALTH: A Neurobiological Perspective

Mattson, Mark P.

doi:10.1146/annurev.nutr.25.050304.092526

Cited by 221 publications

(160 citation statements)

References 146 publications

(172 reference statements)

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“…Therefore, excessive intake of calories may, by itself, lead to deterioration of psychological well-being in workers. Accumulating data suggest that meal size and frequency can affect mental health [53]. Ishihara et al [54] suggest that maintenance of higher psychological wellbeing (lower GHQ-30) following the six-month lifestyle intervention program is parallel to good lifestyle such as low calorie intake.…”

Section: Discussionmentioning

confidence: 99%

Common risk factors for changes in body weight and psychological well-being in Japanese male middle-aged workers

Sagara

Hitomi

Kambayashi

et al. 2009

Environ Health Prev Med

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Objectives Overweight and poor psychological wellbeing are becoming serious health issues in the Japanese workplace. Concurrence of those physical and mental conditions has been pointed out, especially in middle-aged workers. Therefore, we tried to determine common risk factors for body weight gain and the deterioration of psychological well-being in male middle-aged office workers using a five-year follow-up study. Methods We administered General Health Questionnaire-12 (GHQ-12) as an indicator of psychological well-being to 110 male workers with ages ranging from 40-59 years, and analyzed the influence of several psychological factors, namely sense of coherence (SOC), health locus of control (HLC), and lifestyle variables such as exercise frequency, alcohol intake, smoking status, and dietary intake on changes of body mass index and GHQ-12 score. ResultsMcNemar's chi-squared test showed significant concurrence of weight gain and deterioration of psychological well-being after five-year follow-up. Low-SOC score, low frequency of exercise, and high-dietary intake at supper were significantly associated with both weight gain and poorer psychological well-being in workers, results which were supported by multiple regression analysis. Conclusions These results suggest that exercise and calorie restriction seem to prevent weight gain and promote psychological well-being in workers. Low SOC, which implies difficulty in coping with stress, may be an important risk factor not only for deterioration of psychological well-being but also for becoming overweight. These assumptions must be confirmed by conducting future intervention studies on SOC and lifestyle including exercise and eating behavior.

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Section: Discussionmentioning

confidence: 99%

Common risk factors for changes in body weight and psychological well-being in Japanese male middle-aged workers

Sagara

Hitomi

Kambayashi

et al. 2009

Environ Health Prev Med

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“…In rodents, initiating a 30% to 60% reduction in calorie intake below usual ad libitum intake early in life (from shortly after weaning to age 6 months) caused a proportionate 30% to 60% increase in maximum lifespan, whereas a 44% reduction in calorie intake started in adulthood (12 months) extended maximum lifespan by only 10% to 20% [32] . Data from rodents found that CR increases longevity by preventing or delaying chronic diseases including diabetes, atherosclerosis, cardiomyopathy, autoimmune diseases, kidney and respiratory diseases, and cancer [3,[30][31][32] . In addition, CR is capable of decreasing neurodegeneration in the brain and enhancing neurogenesis in animal models of Alzheimer's disease, Parkinson disease, Huntington disease and stroke [27,[32][33][34] .…”

mentioning

confidence: 99%

“…Data from rodents found that CR increases longevity by preventing or delaying chronic diseases including diabetes, atherosclerosis, cardiomyopathy, autoimmune diseases, kidney and respiratory diseases, and cancer [3,[30][31][32] . In addition, CR is capable of decreasing neurodegeneration in the brain and enhancing neurogenesis in animal models of Alzheimer's disease, Parkinson disease, Huntington disease and stroke [27,[32][33][34] . However, reduction of chronic diseases does not completely explain the increased lifespan and preservation of function at more youthful-like states in calorie-restricted rodents.…”

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confidence: 99%

Caloric restriction and heart function: is there a sensible link?

Han

Ren

2010

Acta Pharmacol Sin

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Calorie restriction (CR) is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition. In general, the daily caloric intake subjected to CR has been restricted to 50% to 70% of the average food intake in subjects eating ad libitum [1,2] . CR was first reported to retard aging and prolong median and maximal life span in the 1930s [3] . Over the last several decades, CR has been widely studied which exhibits an apparent beneficial impact on longevity, ageassociated diseases, and attenuation of functional decline, across a broad variety of species (including rats, mice, fish, flies, worms and yeast) [4,5] . Moreover, CR provides protection against a cadre of chronic diseases including diabetes mellitus, neurodegenerative diseases, autoimmune disorders [6][7][8] and cancer [9][10][11][12] . CR has been shown to alter a variety of physiological parameters especially reduced metabolic rate and oxidative damage, resulting in a decrease in the incidence of cardiovascular diseases [13] . In response to energy deficiency, experimental animals experience a drastic decrease in both fat mass and lean body mass. Muscle mass is overtly reduced, although the rate of loss of function and mass/body weight with the aging process is attenuated [9,[14][15][16] . Metabolic rate may decrease transiently although studies have indicated similar metabolic rate per kg lean body mass to that of ad libitum fed rodents in longterm CR protocol [17] . Body temperature, systolic and diastolic blood pressure all decrease [18,19] along with the reduced sympathetic activity [20] . CR-treated animals are more spontaneously active and display superior cognitive abilities compared to their ad libitum counterparts [21,22] .The most prominent mechanism that may be responsible for the beneficial health and physiological effects of CR are usually mediated through increased insulin sensitivity which results in reduced plasma glucose and insulin concentrations and improved glucose tolerance [23] ; reduced levels of oxidative stress (decreased oxidative damage to proteins, lipids and DNA) [24] , increased resistance to various types of stress including heat, oxidative and metabolic stress [25] as well as enhanced immune function [26] . Impact of CR on agingAn inverse relationship between calorie intake and lifespan has been revealed in mice, suggesting a key role for regulators of energy metabolism in the mechanism of CR. Accordingly, CR-induced metabolic reprogramming may be a key event in the mechanism of lifespan extension [27,28] . The age when CR is started, the severity of restriction, and strain or genetic background of animals determine the magnitude of life extension. The only mammals in which CR has clearly been shown ReviewCaloric restriction and heart function: is there a sensible link? Calorie restriction (CR) is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition. Ample of clinical and experimental evidence has demonstrated that CR is capable of retarding aging p...

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“…In that study, nine genes were differentially regulated by calorie restriction in aging mice, but none overlapped with those in our study. Calorie restriction can reduce levels of oxidative stress and protect proteins, lipids and DNA form oxidative damage, thereby possibly contributing to cellular protection against diabetes, cardiovascular disease, cancers and neurodegenerative diseases (Mattson 2005;Mattson and Wan 2005;Sohal and Weindruch 1996). While an acute fast, such as 24-h food deprivation, is a different treatment than longterm calorie restriction, biological processes category such as ''response to DNA damage stimulus'' (GO:0006974), ''oxidation-reduction process'' (GO:0055114) and ''lipid biosynthetic process'' (GO:0008610) was found among the top groups of GO terms.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the hypothalamic transcriptome in response to food deprivation reveals global changes in long noncoding RNA, and cell cycle response genes

et al. 2015

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The hypothalamus integrates energy balance information from the periphery using different neuronal subtypes within each of the hypothalamic areas. However, the effects of prandial state on global mRNA, microRNA and long noncoding (lnc) RNA expression within the whole hypothalamus are largely unknown. In this study, mice were given either a 24-h fast, or ad libitum access to food. RNA samples were analyzed by microarray, and then a subset was confirmed using quantitative real-time PCR (QPCR). A total of 540 mRNAs were either up-or downregulated with food deprivation. Since gene ontology enrichment analyses identified several categories of mRNAs related to cell cycle processes, ten cell-cycle-related genes were further analyzed using QPCR with six confirmed to be significantly up-regulated and one downregulated in response to 24-h fasting. While 22 independent microRNAs were differentially expressed by microarray, secondary analysis by QPCR failed to confirm significant changes with fasting. There were 622 lncRNAs identified as differentially expressed, and of three tested by QPCR, two were confirmed. Overall, this is the first time that expression of hypothalamic lncRNAs has been shown to be responsive to food deprivation. In addition, this study is the first to identify a list of lncRNAs with high expression in RNA extracted from hypothalamus. Individual contributions from specific miRNA, lncRNA and mRNAs to the food deprivation response can now be further studied at the physiological and biochemical levels.

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ENERGY INTAKE, MEAL FREQUENCY, AND HEALTH: A Neurobiological Perspective

Cited by 221 publications

References 146 publications

Common risk factors for changes in body weight and psychological well-being in Japanese male middle-aged workers

Common risk factors for changes in body weight and psychological well-being in Japanese male middle-aged workers

Caloric restriction and heart function: is there a sensible link?

Characterization of the hypothalamic transcriptome in response to food deprivation reveals global changes in long noncoding RNA, and cell cycle response genes

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