Massive gastrointestinal hemorrhage secondary to tumors of Brunner's glands

Ponka, Joseph L.; Shaalan, A.K.

doi:10.1016/0002-9610(64)90079-0

Cited by 17 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…obstructive symptoms. 4,[7][8][9][10] However, lesions that are sessile or limited in size, such as that in our patient, are typically found incidentally by upper gastrointestinal radiography performed to evaluate nonspecific symptoms. 10 Since Brunneromas occupy the submucosal layer, they can be difficult to detect in superficial biopsy specimens.…”

Section: Introductionmentioning

confidence: 99%

Brunner's gland adenoma with a focus of p53-positive atypical glands

Fujimaki¹,

Nakamura

Sugai

et al. 2000

Journal of Gastroenterology

View full text Add to dashboard Cite

A submucosal tumor was resected endoscopically from the duodenal bulb in a 43-year-old man complaining of epigastric discomfort. The tumor, measuring 22 x 20 x 19mm, consisted mainly of Brunner's glands with no atypia. However, close histologic examination disclosed a focus of glands with cellular and structural atypia. The atypical glands showed staining by periodic acid-Schiff, alcian blue, and high iron-diamine methods. Mucin histochemistry was examined, and the atypical glands resembled the excretory ducts rather than the acinar cells of the tumor. Immunohistochemically, positivity for MIB-1 was high (38.0%), and p53-positive cells were detected sporadically in the atypical glands. These results indicated that the atypical glands probably represented a neoplastic lesion. Brunner's gland adenomas associated with foci of true neoplasm are very rare; only two cases, including one patient with microcarcinoid tumors, have been reported.

show abstract

Section: Introductionmentioning

confidence: 99%

Brunner's gland adenoma with a focus of p53-positive atypical glands

Fujimaki¹,

Nakamura

Sugai

et al. 2000

Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…The BGHs in cases 3, 4, and 6 were found during surgery for the gastric ulcers, and case 7 had a partial gastrectomy. Because of the previously reported association of BGH and gastric ulcer, 3,12,13 the specimen was serially sectioned and a nodular lesion was found in the pyloroduodenal junction. Histologically, this lesion was a BGH.…”

Section: Resultsmentioning

confidence: 99%

“…1 Since then, case reports have been sporadic, and virtually all were clinicopathologic studies. [2][3][4][5][6][7][8][9][10][11][12][13] Many patients with BGH were asymptomatic, 13 while others presented with bleeding, 3,[6][7][8]12,13 duodenal obstruction, 7,8,13 intussusception, 2 or obstruction of the common bile duct or pancreatic duct. 4,5 These patients were classified as having hamartomas because the proliferation of the Brunner's gland was accompanied with other components, such as smooth muscle bundles and Paneth cells, all of which are native components of this anatomic location.…”

Section: Introductionmentioning

confidence: 99%

Pathology Update: Brunner's Gland Hamartoma - Is it Just a Morphologic Curiosity?

Coppola

Karl

1997

Cancer Control

View full text Add to dashboard Cite

show abstract

“…Many patients with Brunner's gland adenomas re main asymptomatic, the tumor being found incidentally at autopsy [19]. The two commonest manifestations in the symptomatic patient are abdominal discomfort or pain and gastrointestinal bleeding [19,20], Large tumors produce symptoms of duodenal obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…The two commonest manifestations in the symptomatic patient are abdominal discomfort or pain and gastrointestinal bleeding [19,20], Large tumors produce symptoms of duodenal obstruction. Bleeding varies from gross melena with accompanying hypovo lemic shock to occult anemia in the relatively asymptom atic patient.…”

Section: Discussionmentioning

confidence: 99%