Pathology Update: Brunner's Gland Hamartoma - Is it Just a Morphologic Curiosity?

Coppola, Domenico; Karl, Richard C.

doi:10.1177/107327489700400413

Cited by 2 publications

(3 citation statements)

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“…71 The normal function of the Brunner’s glands is secretion of alkaline fluid; therefore, these glands appear to protect the duodenal mucosa from the damaging action of acidic chyme. 20 Brunner’s glands are most numerous in the first portion of the duodenum, beginning just distal to the pylorus and gradually diminishing toward the second and third portions—thus, the anatomical distribution reflects their physiological role. Brunner’s gland hyperplasia or adenoma is a rare benign condition of the duodenum, with fewer than 200 cases reported.…”

Section: Discussionmentioning

confidence: 99%

“…Brunner’s gland hyperplasia or adenoma is a rare benign condition of the duodenum, with fewer than 200 cases reported. 20 Size is the critical feature in the arbitary distinction between adenoma and hyperplasia. Adenomas are larger than 1 cm, and hyperplasia refers to multiple lesions usually less than 1 cm.…”

Section: Discussionmentioning

confidence: 99%

“…Adenomas are larger than 1 cm, and hyperplasia refers to multiple lesions usually less than 1 cm. 20 About 15% of patients with chronic renal failure have hyperplastic Brunner’s glands detected at endoscopy as multiple polyps in the duodenal bulb. 48 …”

Section: Discussionmentioning

confidence: 99%

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Meeting Report

et al. 2012

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The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding background findings as related to the age, source, strain, and disease status of nonhuman primates. In particular, for safety/biomedical studies, a broader understanding and documentation of lesions would help clarify background from drug-related findings. A workshop and a minisymposium on spontaneous lesions and diseases in nonhuman primates were sponsored by the concurrent Annual Meetings of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology held December 3–4, 2011, in Nashville, Tennessee. The first session had presentations from Drs Lowenstine and Montali, pathologists with extensive experience in wild and zoo populations of nonhuman primates, which was followed by presentations of 20 unique case reports of rare or newly observed spontaneous lesions in nonhuman primates (see online files for access to digital whole-slide images corresponding to each case report at http://www.scanscope.com/ACVP%20Slide%20 Seminars/2011/Primate%20Pathology/view.apml). The minisymposium was composed of 5 nonhuman-primate researchers (Drs Bradley, Cline, Sasseville, Miller, Hutto) who concentrated on background and spontaneous lesions in nonhuman primates used in drug safety studies. Cynomolgus and rhesus macaques were emphasized, with some material presented on common marmosets. Congenital, acquired, inflammatory, and neoplastic changes were highlighed with a focus on clinical, macroscopic, and histopathologic findings that could confound the interpretation of drug safety studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%