Massive edema of the ovaryA report of two cases due to lymphatic permeation by metastatic carcinoma from the uterine cervix

Krašević, Maja; Haller, Herman; Rupčić, Stanko; Behrem, Senija

doi:10.1016/j.ygyno.2004.02.015

Cited by 25 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, potential metastatic disease of the ovaries (lymphoma) similarly causing partial obstruction of venous and lymphatic drainage and resulting edematous ovarian stroma, might explain the ovarian enlargement observed in our patient. Such occurrences have been reported in association with gastric and cervical carcinomas7, 8. Subsequent response to chemotherapy and reduction of metastatic disease‐associated venous and lymphatic obstruction within the ovary might therefore explain the observed resolution of ovarian enlargement.…”

Section: Discussionmentioning

confidence: 87%

“…In approximately half of these patients, massive ovarian edema has been attributed to incomplete or partial torsion of the ovary and associated lymphatic and venous obstruction2–4. Occasionally massive ovarian edema has been noted in association with primary ovarian neoplasms, metastases to the ovaries, and metastatic carcinoma within pelvic and para‐aortic lymph nodes2, 5–8.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Transient bilateral ovarian enlargement associated with large retroperitoneal lymphoma

Dalloul

Sherer

Gorelick

et al. 2007

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

CASE REPORTA 40-year-old woman, para 1, presented with increasing weakness and lower abdominal and pelvic pain of 3 months duration. Her medical history was unremarkable. She had been followed for a known uterine leiomyoma, and at her most recent transabdominal and transvaginal sonographic follow-up 6 months previously both ovaries were considered normal. Physical examination disclosed a healthy individual in no acute distress. She was afebrile, her blood pressure was 120/80 mmHg, and her pulse was 84 bpm. Her abdomen was soft and non-tender. Bimanual examination showed a myomatous uterus of size appropriate to 12 weeks' gestation. Both adnexa were considered mildly enlarged. Laboratory examinations disclosed a normal complete blood cell count, serum electrolytes, blood urea nitrogen, and creatinine. Transabdominal and transvaginal sonography confirmed the presence of a calcified intramural uterine leiomyoma of 6-cm diameter (unchanged from her previous assessment 6 months earlier). Both ovaries appeared homogeneously enlarged, the left measuring 8.4 × 5.4 × 3.5 cm (calculated volume 83 mL) (Figure 1) and the right 7.2 × 3.6 × 3.4 cm (calculated volume 46 mL). Both ovaries contained multiple cystic lesions. Owing to the consideration of possible bilateral adnexal disease, abdominal and pelvic computerized tomography (CT) images were obtained, depicting a large retroperitoneal tumor with marked displacement and compression of the inferior vena cava and renal veins (Figure 2). CT-guided biopsy of the retroperitoneal mass demonstrated diffuse large B cell lymphoma. The patient received multidrug intravenous chemotherapy consisting of cyclophosphamide, vincristine, rituximab, and doxorubicin. Following six cycles of the above medications, follow-up CT imaging demonstrated a significant decrease in the size of the retroperitoneal mass (Figure 3), and transabdominal and transvaginal sonography depicted normal-sized ovaries, the left measuring 4.6 × 3.0 × 1.5 cm (calculated volume 11 mL) (Figure 4) and the right 4.3 × 2.8 × 2.7 cm (calculated volume 17 mL). The patient is currently in complete remission,

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Transient bilateral ovarian enlargement associated with large retroperitoneal lymphoma

Dalloul

Sherer

Gorelick

et al. 2007

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

show abstract

“…In the remaining patients the clinical manifestations have been disorders of menstruation, evidence of androgen excess or both. Massive oedema of ovary 9,10 usually an entirely non-neoplastic proliferation, is rarely secondary to obstruction of lymphatic drainage by metastatic carcinoma 8 and Meigs Syndrome. Ovarian enlargement is unilateral in 90% of cases.…”

Section: Histomorphologymentioning

confidence: 99%

Papillary Serous Cystadenofibroma of Paratubal Cyst With Massive Oedema of Ovary in a Teenage Girl - A Case Report

Bhoi¹,

Sarvesh²,

Rao³

et al. 2013

jemds

View full text Add to dashboard Cite

“…Secondary massive ovarian oedema occurs in a diseased ovary, such as when there is an ovarian mass or cyst-like ovarian capillary haemagioma [12], mucinous and serous cyst adenomas [13, 14], mature cystic teratoma [15], Meig’s syndrome [16], ovarian fibrothecoma [17], and polycystic ovary [5]. And malignancies, causing to lymphatic permeation by metastatic carcinoma from the uterine cervix [19], gastric carcinoma [20], and lymphangitis carcinomatosa [21]. Secondary to the drugs used for ovulation induction [18].…”

Section: Discussionmentioning

confidence: 99%

“…Massive ovarian oedema is commonly associated with normal levels of lactate dehydrogenase levels and tumour markers [3–11]. Secondary massive ovarian oedema rarely occurs in diseased ovaries with associated benign cysts and tumours [5, 12–17], the drugs used for ovulation induction [18] and malignancies [19–21]. Few reported cases of raised Ca-125 levels with or without raised lactate dehydrogenase levels in massive ovarian oedema with Meig’s syndrome, fibrothecomas, and so on are available in the literature [16, 17].…”

Section: Introductionmentioning

confidence: 99%

ecancermedicalscience

Ramar

Pallavi²,

Rajashekar³

et al.

View full text Add to dashboard Cite

Objective:Benign massive ovarian oedema is a rare clinical entity arising from the ovaries, and it poses a significant clinical challenge as it can be easily mistaken for neoplasm. Due to the lack of pathognomonic clinical features or characteristic hallmarks on non-invasive diagnostic modalities and the dependence on the final histopathology, the efforts of the surgeon have been deviated from performing fertility-sparing surgery on young women. The lack of standardised guidelines due to the rarity of this condition calls for a review of the literature to enable the clinician to formulate treatment guidelines.Methods and Material:A Medline search on the PubMed database for literature published in English from 1969 to 2011 was done using the keywords ‘massive ovarian oedema, massive ovarian oedema case report or case series, and pseudotumour of ovary’. A total of 177 women who had undergone a variety of treatments were retrieved. We also report the management options we used for four women presenting to us between August 2000 and October 2011, as well as a review of the literature.Result:A total of 177 cases of massive ovarian oedema were identified. Out of these cases 151 (85.3%) were primary massive ovarian oedema; secondary massive ovarian oedema was identified in 26 (14.7%) cases. A salpingo-oophorectomy was done in 145 (81.9%) cases, 12 (6.8%) cases had an abdominal hysterectomy with bilateral salpingo-oophorectomy. A total of 76 (42.9%) cases intraoperatively were found to have ovarian torsions, and one patient with primary massive ovarian oedema had ascites. Conservative treatment was carried out in 20 (11.3%) patients; 14 of these had a wedge biopsy with frozen section and with or without ovarian suspension, one patient had diagnostic laparotomy, and five cases had only ultrasonographic or magnetic resonance imaging monitoring and symptomatic treatment. The four cases treated at the regional cancer institute from 2000 to 2011 revealed that the first three cases had salpingo-oophorectomy and the fourth case received a successful conservative treatment.Conclusion:The majority of massive ovarian oedemas will respond to judicious use of intraoperative wedge resection and frozen section for the confirmation of diagnosis. The detorsion and transfixation of the ovary or partial debulking and drainage of fluid accumulated in the cyst may be more appropriate to preserve hormonal function and fertility in these young women.

show abstract

Massive edema of the ovaryA report of two cases due to lymphatic permeation by metastatic carcinoma from the uterine cervix

Cited by 25 publications

References 6 publications

Transient bilateral ovarian enlargement associated with large retroperitoneal lymphoma

Transient bilateral ovarian enlargement associated with large retroperitoneal lymphoma

Papillary Serous Cystadenofibroma of Paratubal Cyst With Massive Oedema of Ovary in a Teenage Girl - A Case Report

ecancermedicalscience

Contact Info

Product

Resources

About