Mass spectrometry analytical responses to the SARS-CoV2 coronavirus in review

Griffin, Justin H.; Downard, Kevin M.

doi:10.1016/j.trac.2021.116328

Cited by 31 publications

(26 citation statements)

References 55 publications

(60 reference statements)

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“…In particular, recent reviews confirm how MS-based omic technologies have greatly contributed to the detection of SARS-CoV-2 [20,[28][29][30][31].…”

Section: Introductionmentioning

confidence: 93%

MALDI MS-Based Investigations for SARS-CoV-2 Detection

Preianò

Correnti

Pelaia

et al. 2021

BioChem

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The urgent need to fight the COVID-19 pandemic has impressively stimulated the efforts of the international scientific community, providing an extraordinary wealth of studies. After the sequence of the virus became available in early January 2020, safe and effective vaccines were developed in a time frame much shorter than everybody expected. However, additional studies are required since viral mutations have the potential of facilitating viral transmission, thus reducing the efficacy of developed vaccines. Therefore, improving the current laboratory testing methods and developing new rapid and reliable diagnostic approaches might be useful in managing contact tracing in the fight against both the original SARS-CoV-2 strain and the new, potentially fast-spreading CoV-2 variants. Mass Spectrometry (MS)-based testing methods are being explored, with the challenging promise to overcome the many limitations arising from currently used laboratory testing assays. More specifically, MALDI-MS, since its advent in the mid 1980s, has demonstrated without any doubt the great potential to overcome many unresolved analytical challenges, becoming an effective proteomic tool in several applications, including pathogen identification. With the aim of highlighting the challenges and opportunities that derive from MALDI-based approaches for the detection of SARS-CoV-2 and its variants, we extensively examined the most promising proofs of concept for MALDI studies related to the COVID-19 outbreak.

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“…In particular, recent reviews confirm how MS-based omic technologies have greatly contributed to the detection of SARS-CoV-2 [20,[28][29][30][31].…”

Section: Introductionmentioning

confidence: 93%

MALDI MS-Based Investigations for SARS-CoV-2 Detection

Preianò

Correnti

Pelaia

et al. 2021

BioChem

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“…The enormous social impact this disease has caused over the past two years has led to the development of a great deal of research, proteomics playing a pivotal role in this field [ 15 , 16 , 17 ]. Obviously, most of this research focused on the detection of SARS-CoV-2 viral proteins in the nasopharyngeal and throat swabs that are used to collect virus specimens from COVID-19 patients [ 18 , 19 , 20 ].…”

Section: Sputum Proteomics To Investigate Sars-cov2mentioning

confidence: 99%

Proteomic Analysis of Human Sputum for the Diagnosis of Lung Disorders: Where Are We Today?

Iadarola

Viglio

2022

IJMS

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The identification of markers of inflammatory activity at the early stages of pulmonary diseases which share common characteristics that prevent their clear differentiation is of great significance to avoid misdiagnosis, and to understand the intrinsic molecular mechanism of the disorder. The combination of electrophoretic/chromatographic methods with mass spectrometry is currently a promising approach for the identification of candidate biomarkers of a disease. Since the fluid phase of sputum is a rich source of proteins which could provide an early diagnosis of specific lung disorders, it is frequently used in these studies. This report focuses on the state-of-the-art of the application, over the last ten years (2011–2021), of sputum proteomics in the investigation of severe lung disorders such as COPD; asthma; cystic fibrosis; lung cancer and those caused by COVID-19 infection. Analysis of the complete set of proteins found in sputum of patients affected by these disorders has allowed the identification of proteins whose levels change in response to the organism’s condition. Understanding proteome dynamism may help in associating these proteins with alterations in the physiology or progression of diseases investigated.

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“…An excellent review paper recently published 30 explored many and varied MS responses to SARS-CoV-2. RT-PCR is the most prevalent molecular-based surveillance approach.…”

Section: Ms In the Area Of Covid-19mentioning

confidence: 99%

Mass Spectrometry in Wastewater-Based Epidemiology for the Determination of Small and Large Molecules as Biomarkers of Exposure: Toward a Global View of Environment and Human Health under the COVID-19 Outbreak

Picó

Barceló

2021

ACS Omega

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Wastewater-based epidemiology (WBE) estimates collective consumption or exposure to chemicals or pathogens by monitoring the substances excreted in the population's wastewater. Advances in mass spectrometry (MS) and the application of some clinical diagnostic tools and proteomics to wastewater fingerprinting have been linked to the discovery of new biomarkers and indicators of population health and are broadening the scope of WBE that nowadays cover not only small molecule biomarkers but also genetic biomarkers, large molecules, viruses, infection diseases, resistance, etc. This mini-review highlights recent WBE advances using MS and how this progress can create a fingerprint of a city's health hazards, habits, and lifestyle, which is gaining in public health emphasis.

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Mass spectrometry analytical responses to the SARS-CoV2 coronavirus in review

Cited by 31 publications

References 55 publications

MALDI MS-Based Investigations for SARS-CoV-2 Detection

MALDI MS-Based Investigations for SARS-CoV-2 Detection

Proteomic Analysis of Human Sputum for the Diagnosis of Lung Disorders: Where Are We Today?

Mass Spectrometry in Wastewater-Based Epidemiology for the Determination of Small and Large Molecules as Biomarkers of Exposure: Toward a Global View of Environment and Human Health under the COVID-19 Outbreak

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