Mass Spectrométrie Trace Element Analysis of Calcium Oxalate Uroliths

Hesse, Albrecht; Hj, Dietze; Berg, W; Hienzsch, E

doi:10.1159/000472136

Cited by 29 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They showed that the content of zinc in some urinary stones (such as calcium stones) are almost 15 times more than that in other stones. These findings were also obtained in similar studies by Hesse et al ( 30 ), Levinson et al ( 31 ) and Joost and Tessadri ( 32 ).…”

Section: Discussionsupporting

confidence: 86%

Oral Zinc Sulfate as Adjuvant Treatment in Children With Nephrolithiasis: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

et al. 2015

View full text Add to dashboard Cite

Background:Nephrolithiasis in children is associated with a high rate of complications and recurrence.Objectives:Since some evidences reported that zinc has an important place amongst inhibitors of crystallization and crystal growth, we decided to assess the effectiveness of oral zinc sulfate as adjuvant treatment in children with nephrolithiasis.Patients and Methods:This was a randomized, double-blind, placebo-controlled clinical trial. 102 children in the age range 1 month to 11 years with first nephrolithiasis were recruited. Patients were randomly divided into two equal groups (intervention and control groups). Intervention group received conservative measures for stones and 1 mg/kg/day (maximum 20 mg/day) oral zinc sulfate syrup for 3 months. Control group received placebo in addition to conservative measures, also for 3 months. Patients were followed up by ultrasonography for 9 months, in 5 steps (at the end of 1st, 2nd, 3rd, 6th and 9th month after treatment) assessing size and number of stones in the kidneys.Results:Only at the end of the first month, the average number (intervention: 1.15 ± 3.78, control: 1.3 ± 2.84) (P = 0.001) and size (cm) (intervention: 0.51 ± 1.76, control: 0.62 ± 1.39) (P = 0.001) of stones was significantly lower in the intervention group, and in other points there was no significant therapeutic efficacy in oral zinc adjuvant treatment compared to conservative treatment alone. Also, during the 9-month follow-up, the number and size of stones in both groups decreased significantly (both: P < 0.0001) in a way that the decrease in the intervention group showed no difference with the control group.Conclusions:Adjuvant treatment with zinc is not more effective than consecutive treatment in children with nephrolithiasis. However, further studies are recommended due to the lack of clinical evidence in this field.

show abstract

Section: Discussionsupporting

confidence: 86%

Oral Zinc Sulfate as Adjuvant Treatment in Children With Nephrolithiasis: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Although a few studies have investigated the heavy metal content in urinary stones by physical methods [1,[4][5][6][9][10][11][12][13][14], we could not find such a study conducted in Central Africa, particularly in the Democratic Republic of Congo (DRC). The DRC has been a country of intensive mining activities for centuries.…”

Section: Introductionmentioning

confidence: 99%

Heavy metals in urinary stones in the Democratic Republic of Congo

et al. 2021

View full text Add to dashboard Cite

Background The Democratic Republic of Congo has been a country of intensive mining activities for centuries, but the data on the presence of heavy metals in stones are lacking. This study aimed to identify different heavy metals in urinary tract stones and to investigate their association with the main components of urinary stones. Methods Thirty-six stones from urolithiasis patients (n = 36) followed in 10 hospitals in the Democratic Republic of Congo between January 2016 and September 2019 were analyzed by Fourier transform infrared spectrophotometry. Further analysis using X-ray fluorescence was conducted at the Laboratory of Solids Physics. Results Eight heavy metals were detected in all the stones analyzed. The average (SD) number of heavy metals detected by stone was 5 (1.2). Iron and strontium were detected in all the stones analyzed. Other heavy metals detected included zinc, copper, bromine, rubidium, lead and nickel. Rubidium had the highest concentration in the stones regardless of the sampling site. There was no statistically significant association between the content of heavy metals at the center level and at the crown level of the stones. Rubidium had more affinity with phosphates and purines (p ˂ 0.001). Iron and strontium exhibited a high affinity with weddellite than with whewellite. Conclusion Iron and Strontium were present in all stones analyzed. The presence of heavy metals in stones analyzed might suggest environmental pollution rather than crystalline induction factors.

show abstract

“…Certains aspects, notamment le rôle des éléments traces dans la lithogenèse des calculs de l'arbre urinaire, nécessitent plus d'investigation. En effet, de nombreux travaux soulignent, d'une part, la grande fréquence de ces éléments traces [5,6] et, d'autre part, leur implication dans la formation des calculs [7][8][9]. En effet, il a été montré que, parmi ces éléments, certains pouvaient avoir un rôle déterminant dans la croissance de minéraux [10,11].…”

Section: Introductionunclassified