Mass drug administration of ivermectin, diethylcarbamazine, plus albendazole compared with diethylcarbamazine plus albendazole for reduction of lymphatic filariasis endemicity in Papua New Guinea: a cluster-randomised trial

Laman, Moses; Tavul, Livingstone; Karl, Stephan; Kotty, Bethuel; Kerry, Zebede; Kumai, Stephen; Samuel, Anna; Lorry, Lina; Timinao, Lincoln; Howard, S Cade; Makita, Leo; John, Lucy N.; Bieb, Sibauk; Wangi, James; Albert, Jeffrey M.; Payne, Michael; Weil, Gary J.; Tisch, Daniel J.; Bjerum, Catherine M.; Robinson, Leanne J.; King, Christopher L.

doi:10.1016/s1473-3099(22)00026-3

Cited by 15 publications

(16 citation statements)

References 22 publications

(37 reference statements)

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“…Top hits to DrugBank targets include NADH dehydrogenase , dihydrolipoyl dehydrogenase ( DLD ), mitogen-activated protein kinase 10 , 40S ribosomal protein S2 , fumarate reductase flavoprotein subunit , Rho-related GTP-binding protein RhoB , fibroblast growth factor receptor 1 , and phosphoribosylpyrophosphate (PRPP) synthetase ( Table 3 ; Figure 6 ; Supplementary Table S6 ; Supplementary File S3 ). The drugs identified included albendazole, a known broad-spectrum anthelmintic drug used against Taenia solium and Echinococcus granulosus , which was coupled with antibiotics for killing filarial nematodes ( Turner et al, 2017 ; Laman et al, 2022 ). Moreover, two of the nematode kinases were similar to multiple kinases in the DrugBank Online database.…”

Section: Resultsmentioning

confidence: 99%

“…Current treatment with anthelminthic drugs such as ivermectin is sub-optimal against the adult stage ( Basáñez et al, 2008 ; Diawara et al, 2009 ; Tamarozzi et al, 2011 ). Signs of drug resistance have been observed ( Schwab et al, 2006 ; Laman et al, 2022 ); hence, alternative treatments are urgently needed. New treatment trials have focused on killing the Wolbachia endosymbiont as well as the nematode by using a combination of antibiotics and anthelminthic drugs ( Taylor et al, 2014 ; Turner et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Toward novel treatment against filariasis: Insight into genome-wide co-evolutionary analysis of filarial nematodes and Wolbachia

et al. 2023

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Infectious diseases caused by filarial nematodes are major health problems for humans and animals globally. Current treatment using anti-helminthic drugs requires a long treatment period and is only effective against the microfilarial stage. Most species of filarial nematodes harbor a specific strain of Wolbachia bacteria, which are essential for the survival, development, and reproduction of the nematodes. This parasite-bacteria obligate symbiosis offers a new angle for the cure of filariasis. In this study, we utilized publicly available genome data and putative protein sequences from seven filarial nematode species and their symbiotic Wolbachia to screen for protein–protein interactions that could be a novel target against multiple filarial nematode species. Genome-wide in silico screening was performed to predict molecular interactions based on co-evolutionary signals. We identified over 8,000 pairs of gene families that show evidence of co-evolution based on high correlation score and low false discovery rate (FDR) between gene families and obtained a candidate list that may be keys in filarial nematode–Wolbachia interactions. Functional analysis was conducted on these top-scoring pairs, revealing biological processes related to various signaling processes, adult lifespan, developmental control, lipid and nucleotide metabolism, and RNA modification. Furthermore, network analysis of the top-scoring genes with multiple co-evolving pairs suggests candidate genes in both Wolbachia and the nematode that may play crucial roles at the center of multi-gene networks. A number of the top-scoring genes matched well to known drug targets, suggesting a promising drug-repurposing strategy that could be applicable against multiple filarial nematode species.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toward novel treatment against filariasis: Insight into genome-wide co-evolutionary analysis of filarial nematodes and Wolbachia

et al. 2023

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“…A recent cluster randomized trial compared mass drug administration with a triple‐drug regimen versus the standard two‐drug regimen for lymphatic filariasis. After two rounds, the triple‐drug regimen was superior in reducing microfilaremia prevalence below 1% in all villages 8 …”

Section: Insectamentioning

confidence: 98%

“…After two rounds, the triple-drug regimen was superior in reducing microfilaremia prevalence below 1% in all villages. 8 The treatment of mosquito-borne diseases involves not only managing the systemic symptoms but also addressing the dermatological manifestations. Dermatologists often collaborate with infectious disease specialists to provide comprehensive care to affected individuals.…”

Section: Culicidaementioning

confidence: 99%

“…A new species, Borrelia mayonii, was recently described with a higher pathogenicity and spirochetemia than the aforementioned three species. 8 Early symptoms of Lyme disease include fever, headache, fatigue, and the characteristic bullseye-shaped erythema migrans. Untreated early disease can progress to joints, heart, and nervous system, causing symptoms such as severe headaches, neck stiffness, pain and swelling in the large joints, shooting pains, heart palpitations, and dizziness.…”

Section: Ixodesmentioning

confidence: 99%

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Arthropods and the skin

Jabin,

Salem,

Burningham

et al. 2023

Dermatological Reviews

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Arthropods are responsible for most of the animal‐related emergency room visits each year, and nonvenomous arthropods cause the greatest number of animal‐related deaths in the emergency setting. Physicians should recognize the sequela of common and lethal arthropod bites and stings as they can range from asymptomatic or mild pruritus to fatal anaphylactic reactions. This chapter provides an update on recent advancements in the dermatological manifestations, pathophysiology, and management of conditions caused by arthropod bites and stings. Key topics include emerging treatments for pediculosis, characteristic rashes of mosquito‐borne viral diseases, cutaneous lesions in Chagas disease, new Lyme disease vaccine development, topical Spinosad for scabies, and Loxosceles venom composition and early use of antivenom. Recent research reveals progress in understanding arthropod‐related dermatologic diseases but also persistent knowledge gaps in the literature. This focused update delivers a concise overview of current concepts and developments at the intersection of arthropods and dermatology for clinicians.

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Contribution of the TIM-3/Gal-9 immune checkpoint to tropical parasitic diseases

Bailly

2023

Acta Tropica

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Mass drug administration of ivermectin, diethylcarbamazine, plus albendazole compared with diethylcarbamazine plus albendazole for reduction of lymphatic filariasis endemicity in Papua New Guinea: a cluster-randomised trial

Cited by 15 publications

References 22 publications

Toward novel treatment against filariasis: Insight into genome-wide co-evolutionary analysis of filarial nematodes and Wolbachia

Toward novel treatment against filariasis: Insight into genome-wide co-evolutionary analysis of filarial nematodes and Wolbachia

Arthropods and the skin

Contribution of the TIM-3/Gal-9 immune checkpoint to tropical parasitic diseases

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